A lupene-type triterpene from Mimusops elengi

Jahan, Nusrat; Ahmed, Wasim; Malik, Abdul

doi:10.1016/0031-9422(94)00850-s

Cited by 13 publications

(8 citation statements)

References 13 publications

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“…2); betulinic acid ( Fig. 2); α-spinosterol; Table 1 Names of Mimusops elengi Linn in various languages (Jerline et al, 2009;Mitra, 1981 2); the triterpenes, 3β, 19α, 23-trihydroxy-urs-12-ene; 3β-(p-hydroxy-cis-cinnamoyloxy)urs-12-en-28-oicac acid; 3β-(p-hydroxy-trans-cinnamoyloxy) urs-12-en-28-oic acid; fatty acid ester of α-spinasterol and farnan-2-one-3β-ol (mimusopfarnanol) (Hart, Johns, & Lamberton, 1968;Jahan, Ahmed, & Malik, 1995;Misra & Mitra, 1967Nusrat, Wasim, & Abdul, 1995a;Nusrat, Wasim, & Abdul, 1995b). The flowers contain volatile oils (Mitra, 1981), while the leaves, heartwood and roots are known to have hentriacontane, carotene and lupeol (Misra & Mitra, 1967.…”

Section: Proximate Composition and Phytochemistrymentioning

confidence: 99%

Chemistry and medicinal properties of the Bakul (Mimusops elengi Linn): A review

Baliga

Pai

Bhat³

et al. 2011

Food Research International

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Section: Proximate Composition and Phytochemistrymentioning

confidence: 99%

Chemistry and medicinal properties of the Bakul (Mimusops elengi Linn): A review

Baliga

Pai

Bhat³

et al. 2011

Food Research International

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“…[10] Chemical studies have shown that bark contains taraxerone, taraxerol, spinasterol, [11] sodium salt of betulinic acid, urosolic acid and fatty acid esters of alpha-spinasterol. [12] A stem bark of Mimusops elengi Linn has been used by Ayurvedic practitioners, in rural Maharashtra, to improve the immune system and to battle a number of diseases. However, there are no scientific details available in the literature on the immunomodulatory activity of Mimusops elengi Linn bark extract.…”

Section: Introductionmentioning

confidence: 99%

Immunostimulatory effect of Mimusops elengi Linn stem bark in mice

Shivatare¹,

Kadam²,

Bhusnar³

et al. 2014

Int J Green Pharm

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Objectives: To scrutinise the immunostimulatory activity of methanolic extract of bark of Mimusops elengi Linn (MEMEL) in mice. Materials and Methods: The MEMEL was administered orally at the dose of 10, 20, 40 mg/kg/day body weight in mice. The immunostimulatory activities on specific and non-specific immunity were studied by carbon clearance test (CCT), haemagglutination antibody (HA) and delayed type hypersensitivity, using sheep red blood cells (SRBC) as the antigen. Distilled water served as a control in all the tests and vitamin E 150 mg/kg was used as standard. Result: Oral administration of MEMEL showed a dose-dependent increased immunostimulatory response. Phagocytic index was found to be increased significantly (P < 0.01) in CCT. The production of circulatory antibody titre (humoral antibody response) was increased significantly (P < 0.01) and delayed type hypersensitivity reaction was found to be augmented less significantly (P < 0.05) by increasing the mean footpad thickness at 48 hr in response to SRBC as an antigen. Conclusion: This finding suggests that the MEMEL possesses potential for augmenting immune activity by cellular and humoral-mediated mechanisms.

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“…The major constituents were alpha cadinol, tau muurolol, hexadecanoic acid etc (Ruikar, 2009). The whole plant contains lupeol like triterpenoid, β-amyrin, lupeol, α-taraxerol, ursolic acid (Jahan et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and In Vivo Antihyperglycemic Potential of Mimusops elengi L. in Alloxan-Induced Diabetes in Mice

Ganu¹,

Jadhav²

2010

Journal of Complementary and Integrative Medicine

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Mimusops elengi, commonly called 'Bakul' is a medicinally important plant of family sapotaceae. All parts of the tree have medicinal properties. Sushrut Samhita in the Chikitsa chapter explains the treatment strategies for the diabetes. Mimusops elengi (ME) is endowed with the antidiabetic potential. The present study was aimed to evaluate the in vitro antioxidant and antihyperglycemic property of ME. Aqueous extract of ME (MEAQE) exhibited reducing power as well as DPPH and OH radical scavenging activity in vitro. It can be concluded from above observation that the onset of action of antihyperglycemic activity of MEAQE is at the 2nd hr and duration of action is before the 24th hr. in alloxan-induced diabetes. MEAQE may act by increasing peripheral utilization of glucose. Taking into consideration the traditional claim of ME as an antidiabetic agent and the results suggesting the in vitro antioxidant, radical scavenging activity and in vivo antihyperglycemic activity, it can be concluded that ME exhibited potential to treat diabetes and should be further explored against diabetes and related complications.

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A lupene-type triterpene from Mimusops elengi

Cited by 13 publications

References 13 publications

Chemistry and medicinal properties of the Bakul (Mimusops elengi Linn): A review

Chemistry and medicinal properties of the Bakul (Mimusops elengi Linn): A review

Immunostimulatory effect of Mimusops elengi Linn stem bark in mice

In Vitro Antioxidant and In Vivo Antihyperglycemic Potential of Mimusops elengi L. in Alloxan-Induced Diabetes in Mice

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