A lupane triterpenoid from Maerua oblongifolia

Abdel-Mogib, Μ.

doi:10.1016/s0031-9422(98)00771-7

Cited by 35 publications

(20 citation statements)

References 10 publications

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“…Signals at ı 1.2-1.4 and ı 0.8-0.9 are assignable to alkyl chains and terminal methyl groups, respectively. These features are in agreement with linear-chain unsaturated fatty acids which have been isolated from both Maerua (Abdel-Mogib, 1999) and Securidaca (Smith et al, 1979) genera.…”

Section: Preliminary Phytochemical Investigationsupporting

confidence: 89%

“…Previous study of a related species Maerua oblongifolia reported the isolation of six known fatty acid derivatives, including palmitic acid and its methyl ester, stearic acid, palmitoleic acid, oleic acid methyl ester and linoleic acid methyl ester (the esters were likely formed due to methanolysis of fatty acids during extraction) (Abdel-Mogib, 1999). The 1 H NMR analysis suggested that Maerua edulis n-hexane extract may also contain the above fatty acids in both free and ester forms (singlet at ı 3.65 are corresponding to methoxyl groups).…”

Section: Preliminary Phytochemical Investigationmentioning

confidence: 99%

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Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Luo

Pires

Aínsa

et al. 2011

Journal of Ethnopharmacology

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Aims of the study: It was aimed to assess the in vitro antimycobacterial activity of crude extracts from fifteen medicinal plants and to reveal main classes of compounds which may account for the activity of extracts. Methods and materials:The plant materials were sequentially extracted by n-hexane, dichloromethane, ethyl acetate, and 70% ethanol. Decoction of each plant material was also prepared according to traditional use. Broth microdilution method was employed to screen extracts against two mycobacterial species: Mycobacterium smegmatis ATCC 607 and Mycobacterium tuberculosis H37Rv. The extracts with minimum inhibitory concentration(s) (MIC) below 125 g/mL were considered active and further tested against different mycobacterial species and strains, namely Mycobacterium tuberculosis H37Ra, Mycobacterium bovis BCG ATCC 35734, Mycobacterium smegmatis mc 2 155, Mycobacterium avium DSM 44156 and DSM 44157. Cytotoxic effect was evaluated against human macrophages from the monocytic THP-1 cells. Main classes of compounds in these active extracts were proposed from their 1 H NMR spectroscopic characterizations. Results: n-Hexane extracts of Maerua edulis and Securidaca longepedunculata, ethyl acetate extract of Tabernaemontana elegans and dichloromethane extract of Zanthoxylum capense were found to possess considerable activity against Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Ra with MIC 15.6-62.5 g/mL. Tabernaemontana elegans ethyl acetate extract displayed strong activity against Mycobacterium tuberculosis H37Rv (MIC 15.6 g/mL). Except for Tabernaemontana elegans ethyl acetate extract which presented potent cytotoxic effects in THP-1 cells (IC 50 < 4 g/mL), the other three plant extracts showed moderate to none toxicity. Based on 1 H NMR spectroscopic analysis, major components in both Maerua edulis and Securidaca longepedunculata n-hexane extracts were linear chain unsaturated fatty acids. Zanthoxylum capense dichloromethane extract contained more complex constituents (mostly phenolic compounds). In the most potent extract, Tabernaemontana elegans ethyl acetate extract, the prominent compounds were identified as indole alkaloids. Conclusions: The pronounced antimycobacterial activity of the medicinal plants Maerua edulis, Securidaca longepedunculata, Zanthoxylum capense, and Tabernaemontana elegans suggested that they might provide compounds which could be potential anti-TB drug leads.

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Section: Preliminary Phytochemical Investigationsupporting

confidence: 89%

Section: Preliminary Phytochemical Investigationmentioning

confidence: 99%

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Luo

Pires

Aínsa

et al. 2011

Journal of Ethnopharmacology

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“…On the basis of the comparison of their NMR spectroscopic data with those reported in the literature, the 28 known compounds were identified to be 2-benzoxazolinone (3), 6) tryptanthrin (4), 7) 2-hydroxy-1,4-benzoxazin-3-one (5), 8) 3-(2′-hydroxyphenyl)-4(3H)-quinazolinone (6), 9) 1H-indole-3-carbaldehyde (7), 10) benzouracil (8), 11) 2H-1,4-benzoxazin-3-one (9), 12) 3-carboxyindole (10), 13) acanthaminoside (11), 14) 4(3H)-quinazolinone (12), 15) deoxyvasicinone (13), 16) acanthaminoside isomer (14), 14) lupeol (15), 17) betulin (16), 18) betulinic acid (17), 19) ursolic acid (18), 20) lup-20(29)-en-3β,30-diol (19), 21) maslinic acid (20), 22) guaiacylglycerol-β-ferulic acid ether (21), 23) (2S,3R,4S)-lyoniresinol-3α-O-β-D-glucopyranoside (22), 24) (2R,3S,4R)-lyoniresinol-3α-O-β-D-glucopyranoside (23), 24) (+)-5,5′-dimethoxy-9-O-β-D-glucopyranosyl secoisolariciresinol (24), 25) tyrosol (25), 26) β-hydroxy-benzenepentanoic acid (26), 27) acteoside (27), 28) acteoside isomer (28), 28) loliolide (29), 29) hispiduloside (30). 30) Among these, compounds 3-14 belong to alkaloids (Fig.…”

Section: Resultsmentioning

confidence: 99%

Two New Alkaloids from the Roots of <i>Baphicacanthus cusia</i>

Feng

Zhu

Gao

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The phytosterols were β-sitosterol [18] and stigmasterol [18] . The fatty acids were palmitic [18] , linoleic [18] , oleic [18] , stearic [18] and azelaic (nonandioic) [19] .…”

Section: Resultsmentioning

confidence: 99%

“…The fatty acids were palmitic [18] , linoleic [18] , oleic [18] , stearic [18] and azelaic (nonandioic) [19] . The aromatic acids were 2-hydroxy-4-phenylbutanoic acid 1 [20] , syringic acid 2 [21] , vanillic acid 3 [21] , isoferulic acid 4 [21] and p-coumaric acid 5 [22] .…”

Section: Resultsmentioning

confidence: 99%

Aromatic Constituents of Stachys sp. aff. schimperi

Abdel-Mogib¹,

Al-Zahrani²

2005

sci

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ABSTRACT. Stachys sp. aff. schimperi (family Labiatae) is a widespread species in the south west of the Kingdom of Saudi Arabia. This plant species has not been investigated previously for its chemical constituents. Chromatographic separation of its extract afforded β-sitosterol and stigmasterol. Additionally, some fatty acids, 2-hydroxy-4-phenylbutanoic acid, syringic acid, vanillic acid, isoferulic acid and p-coumaric acid were identified by GC/MS technique. In addition to two flavonoids; 4',5-dihydroxy-6,7,8-trimethoxyflavone and 4',5-dihydroxy-3,6,7,8-tetramethoxyflavone, were identified by the proton NMR and the MS spectra.

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A lupane triterpenoid from Maerua oblongifolia

Cited by 35 publications

References 10 publications

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Two New Alkaloids from the Roots of <i>Baphicacanthus cusia</i>

Aromatic Constituents of Stachys sp. aff. schimperi

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