An ew uranyl containing metal-organic framework, RPL-1:[ (UO 2) 2 (C 28 H 18 O 8)] C H 2 O(RPL for Radiochemical Processing Laboratory), was prepared, structurally characterized, and the solid-state photoluminescence properties explored.S ingle crystal X-ray diffraction data reveals the structure of RPL-1 consists of two crystallographically unique three dimensional, interpenetrating nets with a4 ,3-connected tbo topology.E ach net contains large poresw ith an average width of 22.8 and is formed from monomeric, hexagonal bipyramidalu ranyl nodes that are linked via 1,2,4,5-tetra-kis(4-carboxyphenyl)benzene (TCPB) ligands. The thermal and photophysical properties of RPL-1 were investigated using thermogravimetric analysis and absorbance, fluorescence,a nd lifetimes pectroscopies. The materiald isplays excellentt hermals tability and temperature dependent uranyl and TCPB luminescence. The framework is stable in aqueous mediaa nd due to the large void space (constituting 76 %o f the unit cell by volume) can sequestero rganic dyes, the uptakeo fw hich induces av isible change to the color of the material.