A lubricant and adhesive hydrogel cross-linked from hyaluronic acid and chitosan for articular cartilage regeneration

Qiu, Haofeng; Deng, Junjie; Wei, R.H.; Wang, Xiang; Chen, S.L.; Yang, Yanyu; Gong, Chunhui; Cui, Lingling; Si, Zhangyong; Zhu, Yabin; Wang, Rong; Xiong, Dangsheng

doi:10.1016/j.ijbiomac.2023.125249

Cited by 12 publications

(5 citation statements)

References 31 publications

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“…50 The first strategy is the production of polysaccharides with inbuilt aldehyde through the oxidation of hydroxymethyl groups leading to glycol cleavage with the help of sodium periodate to form aldehyde products. This method of periodate-mediated formation of aldehyde group was utilized in polysaccharides like gum Arabic, 51,52 alginate, [53][54][55] chondroitin sulfate, 29,[56][57][58] dextran, 30,59-61 hyaluronic acid, 31,[62][63][64][65] pectin. [66][67][68][69] In the second strategy, the polysaccharide is generated so that aldehyde groups are present on the ends of the linear polymers as the crosslinking agent.…”

Section: Materials Advances Reviewmentioning

confidence: 99%

Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications

J.,

Solanki,

Dhanka

et al. 2024

Mater. Adv.

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Section: Materials Advances Reviewmentioning

confidence: 99%

Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications

J.,

Solanki,

Dhanka

et al. 2024

Mater. Adv.

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“…Aldehyde groups [46] Hyaluronic acid-transglutaminase (HA-TG) hydrogel Covalent bonds [47] Self-cross-linked oxidized alginate/gelatin hydrogel Aldehyde groups [48] Doublle cross-linked Hyalourinoc acid hydrogel (Deial Alder clic reaction ad phenyl-boronate ester bond) Catechol groups [49] Tyramine-modified hyaluronic acid (HA-Tyr) hydrogel Adhesion to cartilage due to hyaluronic acid [24] Sulfhydryl chondroitin sulfate and polydopamine (CS-PDA) Catechol groups [50] Gelatine-Methacryloyl(GelMA)-glycol chitosan hydrogel Protein and methacrylate groups [51] Eznymytically cross-linked alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF) Aldehyde and dopamine groups [52]…”

Section: Poly(ethyleneglycol)(peg)-basedhydrogelmentioning

confidence: 99%

Bioadhesive and Injectable Hydrogels and Their Correlation with Mesenchymal Stem Cells Differentiation for Cartilage Repair: A Mini-Review

Kováč,

Priščáková,

Gbelcová

et al. 2023

Polymers

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Injectable bioadhesive hydrogels, known for their capacity to carry substances and adaptability in processing, offer great potential across various biomedical applications. They are especially promising in minimally invasive stem cell-based therapies for treating cartilage damage. This approach harnesses readily available mesenchymal stem cells (MSCs) to differentiate into chondrocytes for cartilage regeneration. In this review, we investigate the relationship between bioadhesion and MSC differentiation. We summarize the fundamental principles of bioadhesion and discuss recent trends in bioadhesive hydrogels. Furthermore, we highlight their specific applications in conjunction with stem cells, particularly in the context of cartilage repair. The review also encompasses a discussion on testing methods for bioadhesive hydrogels and direct techniques for differentiating MSCs into hyaline cartilage chondrocytes. These approaches are explored within both clinical and laboratory settings, including the use of genetic tools. While this review offers valuable insights into the interconnected aspects of these topics, it underscores the need for further research to fully grasp the complexities of their relationship.

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“…2023). [ 4 ] Biocompatibility hydrogels are extensively used for their excellent biocompatibility. They are nontoxic and have low immunogenicity, making them suitable for biomedical operations, including medicine delivery and tissue engineering (Elango et al .…”

Section: Introductionmentioning

confidence: 99%

Polyethylene Glycol Cross-Linked Hydrogel for Drug Absorption Properties

Durairaj,

Kalpana,

Kumar

2024

Journal of Pharmacy and Bioallied Sciences

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Three-dimensional polymeric networks called hydrogels have drawn a lot of interest in a variety of biomedical applications because of their distinctive qualities, like high water content and biocompatibility. Hydrogels can be strengthened mechanically and become more stable via cross-linking. In this study, we described the synthesis and characterization of a cross-linked hydrogel made of polyethylene glycol (PEG) capable of absorbing drug. The hydrogel was created by using a polymerization procedure to cross-link PEG chains. In order to allay this worry, we added particular functional groups to the hydrogel matrix that had a strong affinity for glutaraldehyde. These functional groups made it easier for excess glutaraldehyde to be absorbed and sequestered inside the hydrogel, lowering its cytotoxic potential. After incubation with the hydrogel, the residual glutaraldehyde concentration in solution was measured in order to assess the glutaraldehyde absorption potential.

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A lubricant and adhesive hydrogel cross-linked from hyaluronic acid and chitosan for articular cartilage regeneration

Cited by 12 publications

References 31 publications

Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications

Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications

Bioadhesive and Injectable Hydrogels and Their Correlation with Mesenchymal Stem Cells Differentiation for Cartilage Repair: A Mini-Review

Polyethylene Glycol Cross-Linked Hydrogel for Drug Absorption Properties

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