A low thyroglobulin level cannot be used to avoid adjuvant 131I therapy after thyroidectomy for thyroid carcinoma

Zanotti‐Fregonara, Paolo; Grassetto, Gaia; Hindié, Elif; Rubello, Domenico

doi:10.1007/s00259-008-0963-2

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…A similar reasoning is reported by Zanotti-Fregonara et al who recommend administration of 131 I in patients with an undetectable post-surgical Tg. 17 An undetectable Tg level is compatible with RAI therapy when therapeutic benefit is expected and iodine uptake is confirmed by scintigraphy. In the series by Park et al, 47 of 52 patients had one or more high doses of 131 I, and the patients showed resolution, improvement, or stability of the lesions, without any case of disease progression.…”

Section: Discussionmentioning

confidence: 95%

Clinical Benefit of Radioiodine Administration in a Rare Case of Iodine Avid Thyroid Carcinoma with No Secretion of Thyroglobulin

Mouaden,

Guerrouj,

Ghfir

et al. 2023

World J Nucl Med

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Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its outcome is usually favorable. Its basic treatment is well codified, but its monitoring is much less. The value of thyroglobulin (Tg) is one of the main elements for monitoring DTC, while the use of iodine scintigraphy is becoming less recommended. In this case report, we discuss a clinical situation where a patient presented differentiated thyroid metastatic lesions confirmed by biopsy, uptaking radioactive iodine, with undetectable levels of Tg (in the absence of autoantibodies). We discuss the various hypotheses explaining this clinical situation, the potential advantages of performing periodic iodine scintigraphy in some intermediate and high-risk patients and report the documented clinical benefit of radioiodine therapy.

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Section: Discussionmentioning

confidence: 95%

Clinical Benefit of Radioiodine Administration in a Rare Case of Iodine Avid Thyroid Carcinoma with No Secretion of Thyroglobulin

Mouaden,

Guerrouj,

Ghfir

et al. 2023

World J Nucl Med

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“…Low Tg may be seen with poorly differentiated carcinoma or nonimmunoreactive Tg. [ 4 ] Falsely low or high Tg level is also reported in the presence of heterophile antibodies in serum of the patient. In our study Tg was measured with two different techniques and showed persistently low Tg and anti-Tg level throughout the years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Diffuse skeletal metastasis and low thyroglobulin level in a pediatric patient with papillary thyroid carcinoma

2015

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Thyroglobulin (Tg) is frequently measured in follow-up of patients with differentiated thyroid carcinoma. A low stimulated Tg level (<1 ng/ml) associated with normal neck ultrasonography is considered as the most reliable criteria for complete remission in low risk patients. We are reporting a case of pediatric thyroid cancer with diffuse skeletal metastasis associated with low serum Tg level bringing a point of caution in evaluation of patients with low Tg.

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Five months’ follow-up of patients with and without iodine-positive lymph node metastases of thyroid carcinoma as disclosed by 131I-SPECT/CT at the first radioablation

Schmidt

Linke

Uder

et al. 2009

Eur J Nucl Med Mol Imaging

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(131)I-SPECT/CT has a high negative predictive value with regard to the occurrence of radioiodine-positive cervical LNM 5 months after initial therapy. The majority of iodine-positive LNM diagnosed by SPECT/CT at radioablation disappear within 5 months. These findings motivate further research into the value of (131)I-SPECT/CT of the neck for predicting recurrence and planning surgical reintervention in DTC.

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A low thyroglobulin level cannot be used to avoid adjuvant 131I therapy after thyroidectomy for thyroid carcinoma

Cited by 6 publications

References 16 publications

Clinical Benefit of Radioiodine Administration in a Rare Case of Iodine Avid Thyroid Carcinoma with No Secretion of Thyroglobulin

Clinical Benefit of Radioiodine Administration in a Rare Case of Iodine Avid Thyroid Carcinoma with No Secretion of Thyroglobulin

Diffuse skeletal metastasis and low thyroglobulin level in a pediatric patient with papillary thyroid carcinoma

Five months’ follow-up of patients with and without iodine-positive lymph node metastases of thyroid carcinoma as disclosed by 131I-SPECT/CT at the first radioablation

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