A Low-Protein Diet Blocks Development of Hyperphagia and Obesity in Rats with Hypothalamic Knife Cuts

Tuig, Jerry G. Vander; Beneke, William M.

doi:10.1093/jn/126.6.1713

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…Protein and amino acid sufficiency in the body is tightly controlled and might modulate food motivation and food choice to prevent and/or counteract protein deficiency. The underlying mechanisms involve many signals, including amino acid signaling in the brain (23,25,38,41,42) and control of energy metabolism in peripheral tissues (particularly liver, muscle, and white and brown adipose tissue).…”

Section: Introductionmentioning

confidence: 99%

Low-protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice

Blais

Chaumontet

Azzout‐Marniche

et al. 2018

American Journal of Physiology-Endocrinology and Metabolism

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Low protein (LP)-containing diets can induce overeating in rodents and possibly in humans in an effort to meet protein requirement, but the effects on energy expenditure (EE) are unclear. The present study evaluated the changes induced by reducing dietary protein from 20% to 6%-using either soy protein or casein-on energy intake, body composition, and EE in mice housed at 22°C or at 30°C (thermal neutrality). LP feeding increased energy intake and adiposity, more in soy-fed than in casein-fed mice, but also increased EE, thus limiting fat accumulation. The increase in EE was due mainly to an increase in spontaneous motor activity related to EE and not to thermoregulation. However, the high cost of thermoregulation at 22°C and the subsequent heat exchanges between nonshivering thermogenesis, motor activity, and feeding induced large differences in adaptation between mice housed at 22°C and at 30°C.

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Section: Introductionmentioning

confidence: 99%

Low-protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice

Blais

Chaumontet

Azzout‐Marniche

et al. 2018

American Journal of Physiology-Endocrinology and Metabolism

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“…Thus, they may signal energy demands for growth or protein metabolism. In lesioned rats, the obesity syndrome is abolished by low protein diets, suggesting a link between protein metabolism and energy ingestion (Vander Tuig and Beneke 1996). GH treatment has the same effect (Woods et al 1974).…”

Section: High-protein Diet Consumptionmentioning

confidence: 98%

The growth hormone axis, feeding, and central allocative regulation: lessons from giant transgenic growth hormone mice

Rollo¹,

Kajiura²,

Wylie³

et al. 1999

Can. J. Zool.

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Lifetime consumption rates of male transgenic growth hormone (GH) mice and normal controls were measured on either a 38% protein diet (HP), the standard rodent diet (STD) (23.5% protein), or the standard diet supplemented with a free choice of sucrose (CARB). On STD, daily intake of normal mice increased little at sizes greater than 20 g, but larger transgenic mice ate progressively more. Both kinds of mice showed declining daily mass-specific consumption with increasing age. Transgenic mice consistently ate 13.3% less food than normal mice on a mass-specific basis across all ages. On the self-selective CARB diet, normal mice exhibited increasing age-specific daily consumption, whereas transgenic mice exhibited a trend towards age-related decline in mass-specific feeding that proved significant on the basis of body mass. Transgenic mice ingested more sucrose than standard chow and this did not vary with age. In contrast, normal mice ate less sucrose than chow and chose a declining proportion of sucrose with age. Transgenic and normal mice showed a unitary relationship of daily intake of HP in relation to body mass, resulting in constant mass-specific feeding across all ages. Transgenic GH animals, including livestock, show numerous defects that we have attributed to relative energetic stress associated with excessive allocation to lean growth. This is exacerbated by failure to offset increased demands of growth by increasing mass-specific feeding. Results presented here document altered feeding regulation in transgenic GH mice and suggest underlying mechanisms.Résumé : Les taux de consommation durant toute la vie ont été mesurés chez des mâles de souris à hormone de croissance (GH) transgénique soumises à un régime alimentaire contenant 38% de protéines (HP), à un régime standard de rongeur (STD) contenant 23,5% de protéines ou à un régime standard additionné de sucroses au choix (CARB). Au régime STD, la consommation chez les souris normales augmente peu aux tailles supérieures à 20 g, mais les souris transgéniques plus grosses augmentent progressivement leur consommation de nourriture. Les souris des deux types diminuent leur consommation quotidienne de nourriture en fonction de leur masse à mesure qu'elles vieillissent. Les souris transgéniques mangent 13,3% moins de nourriture par unité de masse à tout âge. Au régime CARB, les souris normales augmentent leur consommation quotidienne en fonction de leur âge, alors qu'en vieillissant, les souris transgéniques ont tendance à diminuer significativement leur consommation quotidienne de nourriture par unité de masse. Les souris transgéniques consomment plus de sucroses que de moulée standard, une tendance qui ne varie pas avec l'âge. En revanche, les souris normales consomment moins de sucroses que de moulée et, en vieillissant, intègrent une proportion progressivement moins grande de sucrose dans leur régime. Chez les souris des deux types, il y a une relation unitaire entre la consommation quotidienne de protéines et la masse corporelle, ce qui résulte en une ali...

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“…In this connection, there is a long-felt need to develop the method of HML change measurements in the course of its satisfaction of nutritional need using weight, temporal and rate EFPB characteristics. This method will allow not only assessment of various factor effects on nutritional motivation [1,2,4], but also afford ample opportunities for investigations of eating behavior pharmacological correction [5,8].…”

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confidence: 99%

Characteristics of Rabbit Food-Procuring Behavior as an Indicator of Changes in the Level of Hunger Motivation

2012

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We proposed new method for measuring dynamic changes in hunger motivation in rabbits in the course of satisfaction of nutritional need by weight, time, and rate parameters of effective food-procuring behavior. Transformation of the amount of food eaten into the electric signals was performed using electronic weighing machine incorporated into hardware and software system. The most conclusive characteristic for decrease in hunger motivation in the course of first effective food-procuring act was the period of food-procuring cycles, which values increase significantly as animal satisfies its nutritional need, whereas amount of the food consumed for each food-procuring cycle remains constant. Integral characteristics of food-procuring behavior reflect higher level of food motivation in the course of first effective food-procuring act in comparison to the subsequent ones.

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A Low-Protein Diet Blocks Development of Hyperphagia and Obesity in Rats with Hypothalamic Knife Cuts

Cited by 7 publications

References 22 publications

Low-protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice

Low-protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice

The growth hormone axis, feeding, and central allocative regulation: lessons from giant transgenic growth hormone mice

Characteristics of Rabbit Food-Procuring Behavior as an Indicator of Changes in the Level of Hunger Motivation

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