A Low-Power Integrated Neural Interface with Digital Spike Detection and Isolation

Gosselin, Benoît; Sawan,

doi:10.1109/icecs.2007.4511264

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Our research group has proposed several low-power implantable preamplifiers for neural signal amplification [41][42][43][44][45][46] and more recently, low-power implantable integrated devices for automatic seizure detection [19,20]. The experimental validation of our seizure detector prototype is under-way.…”

Section: The Proposed Implantable Device For Epilepsy Treatmentmentioning

confidence: 99%

Low‐Power Implantable Device for Onset Detection and Subsequent Treatment of Epileptic Seizures: A Review

Salam

Nguyen

2010

Journal of Healthcare Engineering

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Over the past few years, there has been growing interest in neuro-responsive intracerebral local treatments of seizures, such as focal drug delivery, focal cooling, or electrical stimulation. This mode of treatment requires an effective intracerebral electroencephalographic acquisition system, seizure detector, brain stimulator, and wireless system that consume ultra-low power. This review focuses on alternative brain stimulation treatments for medically intractable epilepsy patients. We mainly discuss clinical studies of long-term responsive stimulation and suggest safer optimized therapeutic options for epilepsy. Finally, we conclude our study with the proposed low-power, implantable fully integrated device that automatically detects low-voltage fast activity ictal onsets and triggers focal treatment to disrupt seizure progression. The detection performance was verified using intracerebral electroencephalographic recordings from two patients with epilepsy. Further experimental validation of this prototype is underway.

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Section: The Proposed Implantable Device For Epilepsy Treatmentmentioning

confidence: 99%

Low‐Power Implantable Device for Onset Detection and Subsequent Treatment of Epileptic Seizures: A Review

Salam

Nguyen

2010

Journal of Healthcare Engineering

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“…2 System architecture Figure 1 depicts a block diagram of the implemented neural interface, first introduced in [7]. It is composed of a mixed-signal data acquisition part, and a digital part, implemented separately within two ICs for compact integration with a microelectrode array.…”

Section: Introductionmentioning

confidence: 99%

A low-power integrated neural interface with digital spike detection and extraction

Gosselin

2009

Analog Integr Circ Sig Process

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We present the design of an integrated neural interface intended for multi-channel neural recording. The design features a mixed-signal part that handles neural signal conditioning, digitization, time-division multiplexing, and a digital module providing control, absolute threshold detection, extraction of spikes, and serial communications towards a host interface. The detection and extraction strategy preserves the entire neuronal spike waveshapes by means of synchronized internal data buffering. This bandwidth reduction scheme prompts for better waveform sorting results and improved performance in prosthetic applications. Both parts of the presented neural interface were fabricated separately in a CMOS 0.18 lm process. The whole neural interface features 16 channels for validation, but, the proposed approach is scalable to larger channel counts. The performance of the implemented neural interface was validated on testbench with synthetic neural waveforms. It features a power consumption of 138 lW per channel and a size of 2.304 mm 2 , and achieves a bandwidth reduction factor of up to 48.

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“…Among the popular researches in this direction, we can find the intracortical sensing and stimulation [1,2]. The latter development is dedicated to numerous applications such as multichannel electroneurogram (ENG) recording, neurotransmitter measurement, and stimulation in various regions for functions recuperation such as vision [1][2][3][4][5][6], prevent epilepsy seizure [7], motor control, etc. The high reliability and very low power consumption are among the main criteria that must be given priority to implement such implantable and wirelessly controlled microsystems.…”

Section: Introductionmentioning

confidence: 99%

Implantable Electronics for the Recovery of Neuromuscular Functions

Gosselin

Coulombe

Ayoub

et al. 2008

Advances in Science and Technology

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This paper covers circuits and systems techniques for the construction of high reliability biosensing and stimulation medical devices. Such microsystems are dedicated for interconnections through either the central or the peripheral nervous systems. Low-power high-reliability wireless links are used to power up the implanted devices while data are exchanged bidirectionaly between these implants and external controllers. A global view of main devices is given, case studies related to applications such as bladder control, intracortical monitoring and microstimulation are discussed, altogether with modeling, characterization, as well as microsystems assembly and packaging. Also, dedicated electrode arrays and their interfaces to tissues interfaces are summarized.

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A Low-Power Integrated Neural Interface with Digital Spike Detection and Isolation

Cited by 3 publications

References 7 publications

Low‐Power Implantable Device for Onset Detection and Subsequent Treatment of Epileptic Seizures: A Review

Low‐Power Implantable Device for Onset Detection and Subsequent Treatment of Epileptic Seizures: A Review

A low-power integrated neural interface with digital spike detection and extraction

Implantable Electronics for the Recovery of Neuromuscular Functions

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