A low-noise fully-differential CMOS preamplifier for neural recording applications

Abstract

A fully-differential bandpass CMOS preamplifier for extracellular neural recording is presented in this paper. The capacitive-coupled and capacitive-feedback topology is adopted. We describe the main noise sources of the proposed preamplifier and discuss the methods for achieving the lowest input-referred noise. The preamplifier has a midband gain of 43 dB and a DC gain of 0. The −3 dB upper cut-off frequency of the preamplifier is 6.8 kHz. The lower cut-off frequency can be adjusted for amplifying the field or action potentials located in different bands. It has an input-referred noise of 3.36 μVrms integrated from 1 Hz to 6.8 kHz for recording the local field potentials (LFPs) and the mixed neural spikes with a power dissipation of 24.75 μW from 3.3 V supply. When the passband is configured as 100 Hz-6.8 kHz for only recording spikes, the noise is measured to be 3.01 μVrms. The 0.115 mm 2 prototype chip is designed and fabricated in 0.35-μm N -well CMOS (complementary metal oxide semiconductor) 2P4M process.Keywords neural signal amplifier, low noise, low power, subthreshold circuit design, noise efficiency factor (NEF) CitationZhang X, Pei W H, Huang B J, et al. A low-noise fully-differential CMOS preamplifier for neural recording applications.

Novel wavelet neural network algorithm for continuous and noninvasive dynamic estimation of blood pressure from photoplethysmography

“…Countless scientists and clinicians are dedicated to identifying early warning indicators of these diseases. Therefore, physiological signals acquisition [1][2][3][4][5] and processing [6][7][8][9] have become widespread research topics in recent years. Among these diseases, hypertension has a high incidence.…”

An Implantable Sacral Nerve Root Recording and Stimulation System for Micturition Function Restoration

“…4 (a). It is based on operational transconductance amplifier (OTA) and T-capacitor feedback network topology [27]. Common-mode feedback (CMFB) module is employed to retain the DC level of V on and V op in this circuit.…”

A low-power inverter-based ΣΔ analog-to-digital converter for audio applications

“…Although the gain-boost modules introduce their own poles and zeros in the circuit's frequency response, a nearly ideal settling behavior can be attained by pole and bandwidth optimization [5]. Moreover, the gain-boost modules contribute only a small amount to the overall output noise power because the noise factors associated http://engine.scichina.com/doi/10.1007/s11432-013-4999-y with transistors M3 and M4 are usually much smaller than those of the input transistors M1 and M2 [6]. A spectre simulation indicates that about 7% of the overall output noise power from the proposed class-C inverter is generated by the gain-boost modules.…”