2005
DOI: 10.1073/pnas.0409894102
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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

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Cited by 454 publications
(389 citation statements)
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“…( Grandis et al, 2000;Epling-Burnette et al, 2001;Calvin et al, 2003;Chiarle et al, 2005), siRNA (Konnikova et al, 2003;Lee et al, 2004), small molecules (Song et al, 2005;Turkson et al, 2005) and decoy-oligos (Leong et al, 2003;Chan et al, 2004). In summary, our results demonstrated for the first time that Stat3 phosphorylation is elevated in clinical human endometrial and cervical cancer samples.…”
Section: Discussionsupporting
confidence: 61%
“…( Grandis et al, 2000;Epling-Burnette et al, 2001;Calvin et al, 2003;Chiarle et al, 2005), siRNA (Konnikova et al, 2003;Lee et al, 2004), small molecules (Song et al, 2005;Turkson et al, 2005) and decoy-oligos (Leong et al, 2003;Chan et al, 2004). In summary, our results demonstrated for the first time that Stat3 phosphorylation is elevated in clinical human endometrial and cervical cancer samples.…”
Section: Discussionsupporting
confidence: 61%
“…However, as STAT3 phosphorylation in normal cells is transient, LLL-3 would likely have little effect on the proliferation of normal cells as suggested by its effect on normal bladder smooth muscle cells. Furthermore, studies using normal mouse fibroblasts showed that disrupting STAT3 signalling has much less profound effect in normal human and murine cells Niu et al, 1999;Bowman et al, 2001;Burke et al, 2001;Song et al, 2005), suggesting that blocking STAT3 signalling may not be grossly toxic. Based on our findings, LLL-3 appears to be a potential therapeutic agent for human glioblastoma cells and possibly other tumours that have constitutively active STAT3.…”
Section: Discussionmentioning
confidence: 99%
“…This leads to dimerisation of STAT3 and subsequent transcription to the nucleus where further activation promotes DNA binding and translation of target genes (Carballo et al, 1999). Earlier findings have shown that STA-21, a polyphenol, can inhibit STAT3 activities and induce cell death in breast cancer cells (Song et al, 2005). Using a structure-based strategy, we selected a structural analogue of STA-21 termed as LLL-3 ( Figure 1A), for further evaluation.…”
mentioning
confidence: 99%
“…A Iwamaru et al compound STA-21, a cucurbitacin analog cucurbitacin Q, a new platinum compound CPA-7 and an integrinlinked kinase inhibitor QLT0254 have been reported to inhibit STAT3 and cancer growth in vitro or both in vitro and in vivo (Turkson et al, 2004;Song et al, 2005;Sun et al, 2005;Yau et al, 2005). In line with these studies, we showed that WP1066 significantly inhibited the growth of malignant glioma cells not only in cultured cells, but also in an animal model (Figure 4a).…”
Section: A New Stat3 Inhibitor For Malignant Glioma Cellsmentioning
confidence: 99%