A low level of naturally occurring antibodies associates with functional antibody deficiency

Jensen, Jens Magnus Bernth; Hansen, Anette Tarp; Söderström, Anna; Jørgensen, Charlotte Sværke; Larsen, Carsten Schade; Sørensen, Uffe B. Skov; Thiel, Steffen; Petersen, Mikkel Steen

doi:10.1016/j.clim.2022.109070

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…The qualitative result is expected to be reported using the same VS as in molecular diagnostics. If an additional numerical result 41 , 42 is present, it can be expressed through the Observation.component data element.…”

Section: Resultsmentioning

confidence: 99%

Towards interoperability in infection control: a standard data model for microbiology

Rinaldi,

Drenkhahn,

Gebel

et al. 2023

Sci Data

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The COVID-19 pandemic has made it clear: sharing and exchanging data among research institutions is crucial in order to efficiently respond to global health threats. This can be facilitated by defining health data models based on interoperability standards. In Germany, a national effort is in progress to create common data models using international healthcare IT standards. In this context, collaborative work on a data set module for microbiology is of particular importance as the WHO has declared antimicrobial resistance one of the top global public health threats that humanity is facing. In this article, we describe how we developed a common model for microbiology data in an interdisciplinary collaborative effort and how we make use of the standard HL7 FHIR and terminologies such as SNOMED CT or LOINC to ensure syntactic and semantic interoperability. The use of international healthcare standards qualifies our data model to be adopted beyond the environment where it was first developed and used at an international level.

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Section: Resultsmentioning

confidence: 99%

Towards interoperability in infection control: a standard data model for microbiology

Rinaldi,

Drenkhahn,

Gebel

et al. 2023

Sci Data

View full text Add to dashboard Cite

show abstract

“…For instance, it is not possible from our human studies to assess the preinfection concentrations of anti- Af antibodies in patients who developed viral pneumonia nor in patients with lupus before starting steroids. Thus, it is possible that an unrecognized subtle primary immunodeficiency could account for low natural antibodies ( 73 ). Furthermore, additional mechanistic experiments using an authentic SARS-CoV-2 virus and model will be informative, because the viral pathogenesis is unique compared to the VSV-engineered model presented here.…”

Section: Discussionmentioning

confidence: 99%

A B1a–natural IgG–neutrophil axis is impaired in viral- and steroid-associated aspergillosis

et al. 2022

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The lung naturally resists Aspergillus fumigatus ( Af ) in healthy individuals, but multiple conditions can disrupt this resistance, leading to lethal invasive infections. Core processes of natural resistance and its breakdown are undefined. We investigated three distinct conditions predisposing to lethal aspergillosis—severe SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection, influenza A viral pneumonia, and systemic corticosteroid use—in human patients and murine models. We found a conserved and essential coupling of innate B1a lymphocytes, Af -binding natural immunoglobulin G antibodies, and lung neutrophils. Failure of this axis concealed Af from neutrophils, allowing rapid fungal invasion and disease. Reconstituting the axis with immunoglobulin therapy reestablished resistance, thus representing a realistic pathway to repurpose currently available therapies. Together, we report a vital host resistance pathway that is responsible for protecting against life-threatening aspergillosis in the context of distinct susceptibilities.

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A low level of naturally occurring antibodies associates with functional antibody deficiency

Cited by 2 publications

References 38 publications

Towards interoperability in infection control: a standard data model for microbiology

Towards interoperability in infection control: a standard data model for microbiology

A B1a–natural IgG–neutrophil axis is impaired in viral- and steroid-associated aspergillosis

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