A Low-Cost and Simple Method to Stop Intraoperative Leakage-Type Bleeding: Use of the Vancomycin–Oxidized Regenerated Cellulose (ORC) Sandwich

Abstract

Intraoperative bleeding may cause life-threatening complications in patients if such bleeding cannot be brought under control. Various materials are available for stopping such bleeding. However, there are some difficulties in the acquisition and application of these materials. The aim of this study was to investigate the efficiency of the low-cost and simple-to-prepare vancomycin-oxidized regenerated cellulose (ORC) sandwich in surgical bleeding control. Thirty New Zealand rabbits were used for this purpose. The animals were separated into three groups as group 1 (n = 10), control group; group 2 (n = 10), oxidized regenerated cellulose (ORC) group; and group 3 (n = 10), vancomycin-ORC sandwich group. Left thoracotomies were performed on the rabbits under general anesthesia, and bleeding was created in the parietal pleura. The amount of bleeding in the groups was measured and compared. The amount of bleeding in the group in which the vancomycin-ORC sandwich was used was found to be less, compared to the other two groups. According to these results, we conclude that the vancomycin-ORC sandwich can be used safely in the control of intraoperative leakage-type bleeding, as the vancomycin-ORC sandwich is a low-cost, easily applied, and easily acquired material.

Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery

“…Many topical hemostatic materials have been developed over the past several decades taking these parameters into account, and their clinical benefits and risks have been evaluated. Since ORC was first developed in 1943, numerous studies in various fields have described its hemostatic effects 11121417. Currently, ORC is used not only in laparotomy surgery, but also in endoscopic procedures 18.…”

“…Among topical hemostatic agents, oxidized regenerated cellulose (ORC) has been in use for several decades. ORC conducts hemostatic action through blood absorption, surface interaction with platelets (PLTs) and proteins, and coagulation cascade activation 11. Since its introduction in 1943, several commercial ORC products have been developed,12 and are now frequently used in most gastrointestinal and non-gastrointestinal operations 1314…”

In vitro analysis of polyurethane foam as a topical hemostatic agent

“…The absorbable properties of PEG might contribute to its hemostatic effect by concentration of the endogenous coagulation factors and platelets. The effect of cellulose- and polysaccharide-based hemostats is based partly on this mechanism [17, 23]. …”

Preparation and properties of phosphorylated and crosslinked poly(vinyl alcohol)/bisphenol A–epoxy resin membranes for fuel cell applications

“…In this study, the authors compared four modified cellulose derivatives—OC, OCN, CMC, and DAC with gelatin. The local hemostatic effect of OC had been described in many studies, for example, bleeding from parietal pleura in rabbits10 or of tunica albuginea defect in rabbit testicles 22. During the PN in rats, there were no procedures of hilar vascular control or parenchymal suturing, as hemostasis was achieved solely by the combination of physiological hemostatic mechanisms and characteristics of the applied substances.…”