A low abundance of genus Bacteroides in gut microbiota is negatively correlated with blood phenylalanine levels in Uygur patients with phenylketonuria

Su, Yajie; Shadike, Qiaolibang; Wang, Mingbang; Jiang, Hanqiu; Liu, Wanying; Liu, Jingfang; Tuerdi, Rena; Zhou, Wenhao; Li, Long

doi:10.21037/tp-21-426

Cited by 6 publications

(9 citation statements)

References 27 publications

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“…Furthermore, according to our results, Phe plasmatic levels negatively correlate with Agathobacter after a GMP intervention, suggesting possible beneficial effects of this genus on the Phe metabolism. These data are in agreement with recent findings that showed a lower abundance of Agathobacter in PKU patients with neurological abnormalities [33].…”

Section: Discussionsupporting

confidence: 94%

Glycomacropeptide Safety and Its Effect on Gut Microbiota in Patients with Phenylketonuria: A Pilot Study

et al. 2022

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Glycomacropeptide (GMP) represents a good alternative protein source in Phenylketonuria (PKU). In a mouse model, it has been suggested to exert a prebiotic role on beneficial gut bacteria. In this study, we performed the 16S rRNA sequencing to evaluate the effect of 6 months of GMP supplementation on the gut microbiota of nine PKU patients, comparing their bacterial composition and clinical parameters before and after the intervention. GMP seems to be safe from both the microbiological and the clinical point of view. Indeed, we did not observe dramatic changes in the gut microbiota but a specific prebiotic effect on the butyrate-producer Agathobacter spp. and, to a lesser extent, of Subdoligranulum. Clinically, GMP intake did not show a significant impact on both metabolic control, as phenylalanine values were kept below the age target and nutritional parameters. On the other hand, an amelioration of calcium phosphate homeostasis was observed, with an increase in plasmatic vitamin D and a decrease in alkaline phosphatase. Our results suggest GMP as a safe alternative in the PKU diet and its possible prebiotic role on specific taxa without causing dramatic changes in the commensal microbiota.

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Section: Discussionsupporting

confidence: 94%

Glycomacropeptide Safety and Its Effect on Gut Microbiota in Patients with Phenylketonuria: A Pilot Study

et al. 2022

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“…The included articles were published between 2011 and 2022, and the studies were performed in several countries. Three studies were conducted in Italy [23,30,39], three in the USA [32,33,35], two in the Netherlands [37,38], one in the UK [31], one in Brazil [34], one in China [36], and one in Jordan [29].…”

Section: Resultsmentioning

confidence: 99%

“…The included articles were published between 2016 and 2022 and performed in several countries. Two studies were conducted in Italy [23,30], two in the USA [32,33], one in Brazil [34], one in China [36], and one in the Netherlands [37].…”

Section: Resultsmentioning

confidence: 99%

“…In all of these studies, the analysis was carried out on faecal samples. Illumina technology was used in six of the seven papers [23,30,32,[35][36][37], and only Pinheiro de Oliveira et al (2016) used the Ion Torrent platform [34]. Four studies used Illumina MiSeq [23,30,32,37], one Micro MiSeq [33], and Su et al ( 2021) used a combination of data from Illumina MiSeq PE300 and NOVAseq PE250 [36].…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of Dietary Interventions and Microbiome in Phenylketonuria

Ubaldi,

Frangella,

Volpini

et al. 2023

IJMS

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Inborn errors of metabolism (IEMs) comprise a diverse group of monogenic disorders caused by enzyme deficiencies that result either in a toxic accumulation of metabolic intermediates or a shortage of essential end-products. Certain IEMs, like phenylketonuria (PKU), necessitate stringent dietary intervention that could lead to microbiome dysbiosis, thereby exacerbating the clinical phenotype. The objective of this systematic review was to examine the impact of PKU therapies on the intestinal microbiota. This research was conducted following the PRISMA Statement, with data from PubMed, Scopus, ScienceDirect, and Web of Science. A total of 18 articles meeting the inclusion criteria were published from 2011 to 2022. Significant reductions in several taxonomic groups in individuals with PKU when compared to the control group were detected in a quantitative analysis conducted across seven studies. The meta-analysis synthesis indicates a contrast in biodiversity between PKU subjects and the control population. Additionally, the meta-regression results, derived from the Bacillota/Bacteroidota ratio data, suggest a potential influence of diet in adult PKU populations (p = 0.004). It is worth noting that the limited number of studies calls for further research and analysis in this area. Our findings indicate the necessity of enhancing understanding of microbiota variability in reaction to treatments among PKU subjects to design tailored therapeutic and nutritional interventions to prevent complications resulting from microbiota disruption.

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“…Bacteroides play an important role in gut microbiota-host interactions, particularly in metabolic pathways and the immune system (Maier et al, 2014). In the study by Su et al, a decrease in Bacteroides was negatively correlated with blood phenylalanine levels in a cohort of patients with phenylketonuria (Su et al, 2021). Therefore, it was speculated that the effects of SIOL on phenylalanine, tyrosine, and tryptophan biosynthesis and phenylalanine metabolism might be related to the regulation of the richness of Lactobacillus, Romboutsia, and Bacteroides in the gut.…”

Section: Phenylalanine Metabolism and Phenylalanine Tyrosine And Tryp...mentioning

confidence: 99%

Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen‐induced arthritis in rats

Cong

Wang

Meng

et al. 2022

Phytotherapy Research

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Saussurea involucrata oral liquid (SIOL) can clinically relieve symptoms, such as joint pain and swelling, and morning stiffness, in patients with rheumatoid arthritis (RA).However, the mechanism of action remains unclear. This study used a combination of gut microbiota and serum metabolomics analysis to investigate the effects and potential mechanisms of SIOL intervention on rats with RA induced by type II bovine collagen and Freund's complete adjuvant. Results showed that SIOL treatment consequently improved the degree of ankle joint swelling, joint histopathological changes, joint pathological score, and expression of serum-related inflammatory cytokines (interleukin (IL)-1β, IL-4, IL-6, IL-10, and tumor necrosis factor-α) in RA model rats.16 S rRNA sequencing results showed that SIOL increased the relative richness of the Lactobacillus and Bacteroides genus and decreased the relative richness of Romboutsia, Alloprevotella, Blautia, and Helicobacter genus. Serum nontargeted metabolomic results indicated that SIOL could regulate metabolites related to metabolic pathways, such as glycine, serine, threonine, galactose, cysteine, and methionine metabolism. Spearman correlation analysis showed that the regulatory effects of SIOL on the tricarboxylic acid (TCA) cycle, phenylalanine metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, and glyoxylate and dicarboxylate metabolism pathways were correlated with changes in the richness of the Lactobacillus, Romboutsia, Bacteroides, and Alloprevotella genus in the gut microbiome. In conclusion, this study revealed the ameliorative effects of SIOL on RA and suggested that the therapeutic effects of SIOL on RA may be related to the regulation of the community richness of the Lactobacillus, Romboutsia, Bacteroides, and Alloprevotella genus, thereby improving the TCA cycle; phenylalanine metabolism; phenylalanine, tyrosine, and tryptophan biosynthesis, and glyoxylate and dicarboxylate metabolism-related pathways.

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A low abundance of genus Bacteroides in gut microbiota is negatively correlated with blood phenylalanine levels in Uygur patients with phenylketonuria

Cited by 6 publications

References 27 publications

Glycomacropeptide Safety and Its Effect on Gut Microbiota in Patients with Phenylketonuria: A Pilot Study

Glycomacropeptide Safety and Its Effect on Gut Microbiota in Patients with Phenylketonuria: A Pilot Study

Systematic Review and Meta-Analysis of Dietary Interventions and Microbiome in Phenylketonuria

Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen‐induced arthritis in rats

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