A Lotus shaped acoustofluidic mixer: High throughput homogenisation of liquids in 2 ms using hydrodynamically coupled resonators

Pourabed, Amir; Brenker, Jason; Younas, Tayyaba; He, Lizhong; Alan, Tuncay

doi:10.1016/j.ultsonch.2022.105936

Cited by 14 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are two main methods of achieving such mixing: trapped bubble and sharp edge oscillations. Both methods rely on the acoustic actuation of a piezoelectric transducer bonded to a silicon or glass substrate via a PDMS microchannel [94,[215][216][217][218].…”

Section: Acoustic Mixingmentioning

confidence: 99%

“…Alternatively, oscillating sharp edges, which are structures protruding inside the microchannels, and generally composed of either PDMS [216] or silicon [218] (same as the base material), are relatively immune to such limitations. Upon actuation of the piezoelectric transducer, the sharp edges will oscillate with the applied frequency and generate a pair of counter-rotating vortices at the tip (Fig.…”

Section: Acoustic Mixingmentioning

confidence: 99%

“…NP particle characterization was determined TEM, DLS, and ζ-potential measurement. Pourabed et al [218] developed a microfluidic system where a silicon wafer is sandwiched between two PDMS layers and glued to a piezoelectric disk (Fig. 11c).…”

Section: Acoustic Np Synthesismentioning

confidence: 99%

“…For example, Hood and DeVoe [324] used a COC microchannel with a high aspect ratio of 100:1 to produce liposomes with reasonable size and PDI at a mass flow rate of 100 mg/h, compared to 3 mg/h possible with a standard microchannel design (aspect ratio 0.5:1). Similarly, Pourabed et al [218] used a purposefully built PDMS-silicon-PDMS microchannel with a lotus shaped cavity to acoustically mix precursors at high flowrate of 1.2 mL/min within a short time scale (2 ms) and produce 52 nm PLGA NPs. These afore mentioned challenges could be overcome with continuously improving device designs and experimental procedures.…”

Section: Challengesmentioning

confidence: 99%

“…b PDMS sharp edges microstreaming for the production of PLGA NPs (open access)[220]. c PLGA NPs synthesis by silicon sharp edges (open access)[218]. d Combined oscillatory bubbles and sharp edges to fabricate PLGA NPs[94]…”

mentioning

confidence: 99%

See 4 more Smart Citations

A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods

et al. 2023

View full text Add to dashboard Cite

Recent years have witnessed an increased interest in the development of nanoparticles (NPs) owing to their potential use in a wide variety of biomedical applications, including drug delivery, imaging agents, gene therapy, and vaccines, where recently, lipid nanoparticle mRNA-based vaccines were developed to prevent SARS-CoV-2 causing COVID-19. NPs typically fall into two broad categories: organic and inorganic. Organic NPs mainly include lipid-based and polymer-based nanoparticles, such as liposomes, solid lipid nanoparticles, polymersomes, dendrimers, and polymer micelles. Gold and silver NPs, iron oxide NPs, quantum dots, and carbon and silica-based nanomaterials make up the bulk of the inorganic NPs. These NPs are prepared using a variety of top-down and bottom-up approaches. Microfluidics provide an attractive synthesis alternative and is advantageous compared to the conventional bulk methods. The microfluidic mixing-based production methods offer better control in achieving the desired size, morphology, shape, size distribution, and surface properties of the synthesized NPs. The technology also exhibits excellent process repeatability, fast handling, less sample usage, and yields greater encapsulation efficiencies. In this article, we provide a comprehensive review of the microfluidic-based passive and active mixing techniques for NP synthesis, and their latest developments. Additionally, a summary of microfluidic devices used for NP production is presented. Nonetheless, despite significant advancements in the experimental procedures, complete details of a nanoparticle-based system cannot be deduced from the experiments alone, and thus, multiscale computer simulations are utilized to perform systematic investigations. The work also details the most common multiscale simulation methods and their advancements in unveiling critical mechanisms involved in nanoparticle synthesis and the interaction of nanoparticles with other entities, especially in biomedical and therapeutic systems. Finally, an analysis is provided on the challenges in microfluidics related to nanoparticle synthesis and applications, and the future perspectives, such as large-scale NP synthesis, and hybrid formulations and devices. Graphical abstract

show abstract

Section: Acoustic Mixingmentioning

confidence: 99%

Section: Acoustic Mixingmentioning

confidence: 99%

Section: Acoustic Np Synthesismentioning

confidence: 99%

Section: Challengesmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods

et al. 2023

View full text Add to dashboard Cite

show abstract

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

Huang,

Wu,

Wang

et al. 2023

Electrophoresis

View full text Add to dashboard Cite

An embedded obstacle‐type micromixer‐concentration gradient generator based on capillary self‐driven is proposed and studied. Herringbone structure (HS) for mixing and palisade‐shape small channels at the outlet are designed in the device (named HS). Simulation and experimentation are done to study the liquid mixing efficiency in the small channels and concentration gradient at the outlet, and the experimental results agree with the simulation results. For three cases of liquid dripping (sequential, reverse, and delayed drippings), mixing analysis shows that the mixing efficiency increases along both mixing channel and palisade length, and is high in the middle small channel of the palisade‐shape area and low on both sides. An obvious concentration gradient at the outlet can form compared with the device without the palisade‐shape area. Finally, water pH value detection is done as one of the applications of HS. This study can provide guidance for the application of HS in biochemical detection, cell research, drug screening, etc. based on the capillary‐driven effect.

show abstract

Mixing enhancement in an acousto-inertial microfluidic system

Kharaji

Kalantar

Bayareh

2023

Chemical Engineering and Processing - Process Intensification

View full text Add to dashboard Cite

A Lotus shaped acoustofluidic mixer: High throughput homogenisation of liquids in 2 ms using hydrodynamically coupled resonators

Cited by 14 publications

References 32 publications

A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods

A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

Mixing enhancement in an acousto-inertial microfluidic system

Contact Info

Product

Resources

About