A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR

Lau, Tat-San; Chan, LK; Wong, Eileen Chin Mei; Hui, Connie W. C.; Sneddon, Kenneth P.; Cheung, Tak‐Hong; Yim, SF; Lee, Jacqueline Ho Sze; Yeung, C S-Y; Chung, Tony K.H.; Kwong, Joseph

doi:10.1038/onc.2016.509

Cited by 75 publications

(61 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interference with the action of CXCL12 produced by CAFs promotes T cell-mediated tumour control 16,121,122 , and targeting focal adhesion kinase (FAK) in cancer cells concomitantly reduces stromal fibroblast activation and the development of an immunosuppressive environment 123 . However, the situation with tumour necrosis factor (TNF) produced by CAFs is more nuanced; the tumour-promoting immunosuppressive activity of FAP + fibroblasts is associated with suppression of TNF signalling, yet TNF is also able to drive fibroblast activation in certain contexts 16,124,125 .…”

Section: The Expanding Range Of Caf Functionsmentioning

confidence: 99%

A framework for advancing our understanding of cancer-associated fibroblasts

et al. 2020

View full text Add to dashboard Cite

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment. Extracellular matrix (ECM).The structural network of secreted proteins and glycosaminoglycans that provides structure to tissue. Angiogenesis The formation of new blood vessels. Mesenchyme A type of tissue composed of loosely associated cells surrounded by extracellular matrix. Mesoderm one of three fundamental layers of tissue formed early in development and the predominant source of fibroblastic lineages.

show abstract

Section: The Expanding Range Of Caf Functionsmentioning

confidence: 99%

A framework for advancing our understanding of cancer-associated fibroblasts

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Our previous study has suggested that miR-152-3p suppressed PC cells migration and invasion by downregulating TGF-α [14]. The aberrant expression of TGF-α and TGF-α-induced signaling was involved in the progression and metastasis of various carcinomas [25][26][27]. TGF-α was found to bind to EGFR ligands and activate EGFR by inducing EGFR tyrosine autophosphorylation [28].…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circANKS1B as the Sponge of miR-152-3p Promotes Prostate Cancer Progression by up-Regulating TGF-α Expression

Liu

Pan

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Growing studies indicate that circRNAs play critical roles in human diseases, and show great potential as biomarkers and therapeutic targets. This study aims to investigate the expression and function of circANKS1B in prostate cancer (PC).Methods: The expression of circANKS1B and miRNA-152-3p were determined by real-time qRT-PCR. The cell migration and invasion were measured by transwell assay. The interaction between circANKS1B and miR-152-3p was confirmed by dual-luciferase reporter gene assay. Rescue experiments were conducted to demonstrate whether circANKS1B regulated the migration and invasion of PC cells by the circANKS1B-miR-152-3p-TGF-α pathway.Results: The expression of circANKS1B was dramatically up-regulated both in PC cells and tissues. Moreover, high circANKS1B expression was associated with a poor prognosis of PC patients. Dual-luciferase reporter assay indicated that circABKS1B directly bound to miRNA-152-3p. Furthermore, circANKS1B negatively regulated miR-152-3p expression. Knockdown of circANKS1B remarkably suppressed PC cells invasion and TGF-α expression, while the effects of circANKS1B silencing were reversed by miR-152-3p deficiency. In addition, the impact of miR-152-3p silencing on PC cell invasion was also abrogated by TGF-α deficiency. In all, circANKS1B as the sponge of miR-152-3p promotes prostate cancer progression by up-regulating TGF-α expression.Conclusion: Our findings reveal that circANKS1B could be a potential prognostic biomarker and therapeutic target of PC.

show abstract

“…Growth factors play an important role in maintaining tissue homeostasis under physiological conditions, but in cancer, the same growth factors can be involved in tumor progression [ 60 ]. As with cytokines, cells from the tumor microenvironment are able to secrete growth factors and regulate processes that are important for tumor development such as angiogenesis and metastasis, including the function of CSC and tumor initiation [ 61 , 62 ].…”

Section: Ovarian Cscs and Growth Factorsmentioning

confidence: 99%

“…One of the characteristic of the CA-MSCs is the upregulation of the TGF- β superfamily/BMP family members in comparison with control MSCs, and this activation in the BMP signaling pathways increases the population of ovarian CSCs promoting the CSC proliferation [ 75 ]. Other factors such as TNF- α and TGF- α , released by different types of cells in the tumor microenvironment, have also been identified with a potential role in the ovarian cancer progression [ 62 ]. The exact nature of their interactions with CSCs remains to be clearly established.…”

Section: Ovarian Cscs and Growth Factorsmentioning

confidence: 99%

The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment

Varas-Godoy

Rice

Illanes

2017

Stem Cells International

View full text Add to dashboard Cite

Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer.

show abstract

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR

Cited by 75 publications

References 51 publications

A framework for advancing our understanding of cancer-associated fibroblasts

A framework for advancing our understanding of cancer-associated fibroblasts

Circular RNA circANKS1B as the Sponge of miR-152-3p Promotes Prostate Cancer Progression by up-Regulating TGF-α Expression

The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment

Contact Info

Product

Resources

About