A look into the relationship between outdated coronavirus disease 2019 (COVID-19) treatment protocols and the overwhelming rise of mucormycosis in COVID-19 patients in India

Jamal, Saad Ahmed; Rayapati, Aashish

doi:10.1017/ice.2021.385

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…5 Of them had history of frequent use of nebulisers and steam inhalation, which are also suspected to be associated with the rise in mucormycosis, due to the unsterilized equipment used and poor water quality. [16][17][18] In our study, the mean time period of presentation was around 18 days after recovery from covid-19. Some patients even presented after 2-3 months following covid treatment, which necessitates the need of prolonged follow up following covid recovery.…”

Section: Discussionmentioning

confidence: 53%

Posterior segment findings in post-Covid mucormycosis: A cross-sectional study

Shams

Kumari²,

Mutt³

et al. 2022

IJOOO

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To assess the posterior segment findings in cases presenting with post covid mucormycosis. A cross-sectional observational study was conducted on patients presented with post-covid mucormycosis who were admitted in our hospital during the time period from 1/5/2021 to 1/9/2021. Our study included cases with and without orbital involvement. Anterior segment examination and fundus examination using indirect ophthalmoscopy was done. Findings were photo documented with fundus camera.: In a cohort of 248 patients, 183 (73.7%) were males and 65 (26.2%) were females. 210 (84.67%) were diabetics. The mean age was 50.00 +/-12.33 years. A total of 480 eyes were evaluated, out of which 151 (31.45%) had orbital involvement. Of these 151, 65 had normal fundus, 26 (17.21%) had diabetic retinopathy, 22 had CRAO, 12 had disc pallor, 10 had disc edema and 16 had miscellaneous changes. Out of 329 uninvolved eyes, 239 had normal fundus, 53 (16.10%) had diabetic retinopathy. There was no statistically significant difference between the prevalence of diabetic retinopathy in eyes with orbital involvement and without orbital involvement (p=.39). One-third of the patients with post-covid mucormycosis had retinal findings. These are related to direct disease manifestation as well as underlying co-morbidities.

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Section: Discussionmentioning

confidence: 53%

Posterior segment findings in post-Covid mucormycosis: A cross-sectional study

Shams

Kumari²,

Mutt³

et al. 2022

IJOOO

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show abstract

“…These receptors might facilitate adhesion as well as tissue invasion by mucormycetes, which could aid entry of this pathogen into the nasal sinuses, lungs, and brain. 4,5,7 Statins have been suggested as a treatment to modulate GRP78 receptors and prevent invasive spread of the fungus. The pathophysiology of CNS involvement in mucormycosis was proposed in a report from the Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC) study, 6 which-with 2826 patients-is the largest case series of COVID-19-associated mucormycosis to date.…”

Section: Neurological Infections In 2021: a Spotlight On Indiamentioning

confidence: 99%

“…Analyses of COVID-19 treatment protocols used in India this year 4 , 5 showed that indiscriminate use of corticosteroids, poor control of hyperglycaemia (in people with known or newly diagnosed diabetes), impaired immunity, blanket use of antibiotics, high intake of zinc, prolonged hospital stay, use of industrial oxygen, and ventilators with defective humidifiers were associated with the outbreak of COVID-19-associated mucormycosis. Moreover, COVID-19-related complications, such as cytokine storm, associated hyperglycaemia, and multiorgan dysfunction, have provided a near-perfect acidotic milieu for unabated growth of mucormycetes.…”

mentioning

confidence: 99%