A Look at Commonly Utilized Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in Chronic Pain

Abstract

Purpose of Review Chronic pain continues to be one of the leading healthcare cost burdens in the United States and is typically defined as ongoing pain, lasting longer than six months. Various treatment options exist for chronic pain, including physical therapy, medical management, pain psychology, and interventional therapies. Pain medications have been the mainstay of treatment for chronic pain conditions with an increasing use of membrane stabilizers and antidepressants to treat neuropathic pain conditions. Specifically, serotonin noradrenaline reuptake inhibitors (SNRIs) have been used to treat a range of pain conditions expanding from everyday use for depressive disorders. Recent Findings SNRIs, including duloxetine, venlafaxine, and milnacipran, have demonstrated efficacy in reducing pain in musculoskeletal pain (chronic low back pain and osteoarthritis), fibromyalgia, and neuropathic pain conditions (peripheral diabetic neuropathy). Summary The article describes the function, role, and use of SNRIs to treat chronic and neuropathic pain by altering the noradrenergic descending inhibitory pathways.

Role of Palliative Care in the Supportive Management of AL Amyloidosis—A Review

“…Venlafaxine is available in extended-release oral formulation for once-daily dosing. SNRIs have the additional benefit of helping with mood disturbances [62]. Typical side effects of these agents include fatigue, jitteriness, sedation, and bruxism.…”

“…Counseling, support, early institution of specialized psychiatric services, and the use of selective serotonin reuptake inhibitors (SSRIs) may be helpful in managing these symptoms and improving overall QOL [11]. The SNRI duloxetine may help with both mood disturbances and neuropathic pain [54,62]. However, it should be noted that TCAs, SNRIs, and SSRIs have all been linked to sexual dysfunction.…”

Effectiveness of venlafaxine in patients with ankylosing spondylitis with a neuropathic component of the pain syndrome

“…У пошуках засобів корекції НБ увагу дослідників привертають сучасні антидепресанти групи селективних інгібіторів зворотного захоплення серотоніну та норадреналіну (СІЗЗСН). СІЗЗСН характеризуються потужним тимостабілізаційним та анксіолітичним ефектами, що є цінним для лікування нозогенних депресивних і тривожних розладів, а також анальгезивним ефектом, що спонукає до вивчення можливості їхнього застосування для контролю больового синдрому різного ґенезу [27,30,33]. У дослідженнях останніх років була показана ефективність дулоксетину в лікуванні больового синдрому при АС [5], але ефективність СІЗЗСН у корекції НБ при АС залишається недостатньо вивченою.…”

Burning Mouth Syndrome Treated with Mandibular and Maxillary Nerve Blocks

“…Additionally, these patients may benefit from a trial of neuropathic medications which can be helpful for both chronic pain and psychiatric conditions. 6,7 Our case demonstrates a possible therapy that can be considered for refractory cases of this condition, though more research on this is ultimately needed.…”