A longitudinal study of the associations of <i>BDNF</i> genotype and methylation with poststroke anxiety

Kang, Hee‐Ju; Kim, Kyu‐On; Kim, Ju‐Wan; Kim, Sung‐Wan; Park, Man‐Seok; Kim, Hye‐Ran; Shin, Myung‐Geun; Cho, Ki‐Hyun; Kim, Jae Min

doi:10.1002/gps.5185

Cited by 11 publications

(5 citation statements)

References 64 publications

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“…It was reported that stroke patients with brain-derived neurotrophic factor gene hypermethylation levels and brain-derived neurotrophic factor gene polymorphisms had a higher risk of developing post-stroke depression and post-stroke anxiety (PSA)[ 13 , 14 ]. In addition, polymorphism in the tryptophan hydroxylase 2 gene were also found to be involved in PSA susceptibility[ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

Zhang¹,

Xu²,

Liu³

et al. 2020

WJP

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A spectrum of neuropsychiatric disorders is a common complication from stroke. Neuropsychiatric disorders after stroke have negative effects on functional recovery, increasing the rate of mortality and disability of stroke survivors. Given the vital significance of maintaining physical and mental health in stroke patients, neuropsychiatric issues after stroke have raised concerns by clinicians and researchers. This mini-review focuses on the most common non-cognitive functional neuropsychiatric disorders seen after stroke, including depressive disorders, anxiety disorders, post-traumatic stress disorder, psychosis, and psychotic disorders. For each condition, the clinical performance, epidemiology, identification of the therapeutic implication, and strategies are reviewed and discussed; the main opinions and perspectives presented here are based on the latest controlled studies, meta-analysis, or updated systematic reviews. In the absence of data from controlled studies, consensus recommendations were provided accordingly.

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Section: Introductionmentioning

confidence: 99%

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

Zhang¹,

Xu²,

Liu³

et al. 2020

WJP

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“…Regarding the BDNF gene, a higher methylation status has generally been associated with a more severe depressive episode [ 85 , 90 , 91 ]. Kang and colleagues specifically associated a higher BDNF promoter methylation status with a history of suicide attempts, suicidal ideation during treatment, and suicidal ideation at the last psychiatric evaluation.…”

Section: Discussionmentioning

confidence: 99%

DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression

Vidovič,

Pelikan,

Atanasova

et al. 2023

CIMB

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Depression and anxiety are common mental disorders that often occur together. Stress is an important risk factor for both disorders, affecting pathophysiological processes through epigenetic changes that mediate gene–environment interactions. In this study, we explored two proposed models about the dynamic nature of DNA methylation in anxiety and depression: a stable change, in which DNA methylation accumulates over time as a function of the duration of clinical symptoms of anxiety and depression, or a flexible change, in which DNA methylation correlates with the acute severity of clinical symptoms. Symptom severity was assessed using clinical questionnaires for anxiety and depression (BDI-II, IDS-C, and HAM-A), and the current episode and the total lifetime symptom duration was obtained from patients’ medical records. Peripheral blood DNA methylation levels were determined for the BDNF, COMT, and SLC6A4 genes. We found a significant negative correlation between COMT_1 amplicon methylation and acute symptom scores, with BDI-II (R(22) = 0.190, p = 0.033), IDS-C (R(22) = 0.199, p = 0.029), and HAM-A (R(22) = 0.231, p = 0.018) all showing a similar degree of correlation. Our results suggest that DNA methylation follows flexible dynamics, with methylation levels closely associated with acute clinical presentation rather than with the duration of anxiety and depression. These results provide important insights into the dynamic nature of DNA methylation in anxiety and affective disorders and contribute to our understanding of the complex interplay between stress, epigenetics, and individual phenotype.

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“…The brain derived neurotrophic factor (BDNF) is a critical contributor to neuronal growth, development, learning, and memory 47. BDNF expression associated with the pathophysiology of anxiety 48,49 . Clinical studies have revealed that GAD has been showed lowered plasma BDNF levels 50-52.…”

Section: Discussionmentioning

confidence: 99%

The Molecular Mechanisms of Suanzaoren Prescription for Anti-Anxiety Were Investigated Based on Network Pharmacology

Bao

Wang

et al. 2021

Preprint

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Anxiety is a common, universal disease caused by psychological and environmental factors. There are medications available to treat anxiety disorders, but these are accompanied by problems such as addiction and withdrawal difficulties. Suanzaoren Prescription (SZRP) is often used to treat anxiety disorders in traditional Chinese medicine clinical practice. However, its therapeutic mechanism remains unclear. This work aims to identify potential core therapeutic targets and predict major bioactive compounds by means of network pharmacology, screen compounds that may bind to anxiety targets by molecular docking methods, and validate and evaluate possible therapeutic mechanisms of compounds for anxiety in vitro cell experiments. Datebase TCMSP, BATMAN-TCM, ETCM, TCMGeneDIT and TCMID was used to obtain SZRP compounds, while TCMSP, BATMAN-TCM and ETCM were used to obtain target of compounds. The targets of anxiety disorders were obtained through database TTD, OMIM, PharmgKB, CTD, DrugBank and Metacore. The network diagram is drawn by Cytoscape 3.7.2 software and STRING. Biological process and KEGG pathway analysis were conducted by MetaCore and NIMNT. AutoDock Vina software was used to conduct molecular docking. The calcium Flux assay was employed to detect the activation of compounds on CNR1 in cell line CHO-K1/CNR1/Gα15. The 545 compounds in SZRP were collected. We found there were 1050 potential targets of these compounds in SZRP which involved in brain disease, mood disorder, endocrine system disease, bipolar disorder, etc. There were 117 potential targets of SZRP against anxiety (such as DRD2, BDNF, COMT, SLC6A4, HTR1A, etc.), which played the roles in regulation of membrane potential and synaptic transmission, nicotine addiction, retinol metabolism, GABAergic and serotonergic synapse, etc. The results of molecular docking indicated there were the biggest affinity between Jujuboside B and DRD2, BDNF, COMT, SLC6A4, Anemarsaponin B_qt and HTR1A, n-methylasimilobine and MAPK3. Based on cell CHO-K1/CNR1/Gα15 and calcium flux technique, we found Chrysophanol, Kaempferol and Emodin have activation effects on CNR1 with EC50 138.3µM, 52.28µM and 56.86µM respectively. These results indicated that the effects of SZRP against anxiety were correlated with synaptic transmission, substance addiction and retinol metabolism, especially targeted on CNR1. It suggested that the therapeutic mechanism of SZRP treating anxiety might be due to the weak action of multiple compounds on multiple pathways and biological processes.

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A longitudinal study of the associations of BDNF genotype and methylation with poststroke anxiety

Cited by 11 publications

References 64 publications

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression

The Molecular Mechanisms of Suanzaoren Prescription for Anti-Anxiety Were Investigated Based on Network Pharmacology

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