A longitudinal study of the predictors of prevalence and severity of symptoms commonly associated with menopause

Ford, Kathleen; Sowers, MaryFran; Crutchfield, Mary; Wilson, Angela; Jannausch, Mary

doi:10.1097/01.gme.0000163869.89878.d9

Cited by 89 publications

(73 citation statements)

References 20 publications

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“…In these analyses, we confirmed findings from previous studies, such as the strong, positive, independent association between body mass and incontinence [28,40,41]. The association between body mass and incontinence, as well as the association between smoking and irritability, provide additional data to support what is already known about the adverse effects of smoking and high body mass on health among midlife women and those who are aging.…”

Section: Discussionsupporting

confidence: 89%

“…First, there are large differences in the characteristics of the populations under study; for example, Ford et al [28] enrolled women at a younger age than our study and did not exclude hormone therapy users, as we did. Another potential explanation for the conflicting results is that data and blood collection in our study was not timed to a particular day or phase of the menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, in a population-based sample of 436 women in Philadelphia County, Pennsylvania, Hollander et al [14] showed that poor sleep was associated with low estradiol levels in women aged 45 to 49 years. Further, Ford et al [28] showed using data from the Michigan Bone Health Study that higher estradiol levels were associated with lower odds of being in the highest quartile of bothersome sleep/fatigue compared to the lower quartile (OR 0.7; 95% CI 0.6, 0.9). Recent publications from the Penn Ovarian Aging Study and the Seattle Midlife Women's Health Study reported no association between estradiol and poor sleep or sleep problems [5,24].…”

Section: Discussionmentioning

confidence: 99%

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Endogenous hormones, participant characteristics, and symptoms among midlife women

et al. 2008

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Objectives-The primary aim of this study was to examine the associations between endogenous hormone levels and symptoms other than hot flashes in a sample of midlife women.Methods-Data from a community-based sample of 603 women aged 45 to 54 years who had never used hormone therapy were analyzed. Each participant completed a questionnaire to obtain data on demographic and lifestyle characteristics as well as symptoms, including headache, insomnia, vision problems, vaginal discharge and dryness, irritability, and incontinence. In addition, each participant provided a blood sample that was used to measure estrogen, androgen, and sex hormone binding globulin (SHBG) concentrations by enzyme-linked immunosorbent assay.Results-Prevalence rates of symptoms ranged from 51.4% (irritability) to 18.6% (vision problems). In adjusted analyses, the free estradiol index (FEI) was significantly and positively associated with the reporting of insomnia (odds ratio (OR) 1.28; 95% confidence interval (CI) 1.01, 1.61). Further, higher SHBG levels were significantly associated with lower odds of reporting vision problems (OR 0.44; 95% CI 0.23, 0.81).Conclusions-This study provides evidence that hormones are associated with insomnia and visual problems during midlife. However, some of these results conflict with previous findings. Given the overall paucity of literature on these issues, more investigation is warranted.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endogenous hormones, participant characteristics, and symptoms among midlife women

et al. 2008

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“…63,64 The latter model is questioned by the findings of a case-control study by Gallicchio et al 65 and a cross-sectional study by Schilling et al, 66 who found significantly lower levels of estrogen in obese women (BMI 35 kg=m 2 , BMI >30 kg=m 2 , respectively) compared with normal-weight midlife women (BMI <25 kg=m 2 ). Similarly, other studies indicate that higher BMI 10,52,54,65,67,68 and a higher percentage of body fat 63,69 are associated with increased odds of reporting VMS. Although there is greater evidence in support of the thermoregulatory model than the thin hypothesis, it cannot solely explain the pathogenesis of HFs.…”

Section: Body Mass Index and Obesitymentioning

confidence: 79%

Factors That May Influence the Experience of Hot Flushes by Healthy Middle-Aged Women

Ziv‐Gal¹,

Flaws

2010

Journal of Women's Health

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Background: Interest in menopausal symptoms in general and hot flushes (HFs) in particular has grown in recent years. This is mostly due to increased awareness and the vast impact these symptoms have on women's lives. Despite the high prevalence of women who experience HFs, a definitive etiology for HFs is yet to be found. Our objective was to review the current literature dealing with associated factors for experiencing HFs and to provide a synthesized overview on this common and often debilitating condition. Methods: We systematically searched the English-language literature in the PubMed database using relevant key words and included only those articles that contained information on associated factors for HFs in generally healthy midlife women. Results: Both conflicting scientific results between studies documenting factors that influence HFs and the lack of validated measuring tools make it difficult to truly pinpoint associated factors for HFs. Nonetheless, we identified the following clusters of associated factors: the menopausal stages, sex steroid hormones, other endocrine agents, genetic polymorphisms, race=ethnicity, body mass index (BMI) and obesity, mood disorders, smoking, soy isoflavones and phytoestrogens, alcohol consumption, and physical activity. Conclusions: No single associated factor was consistently identified as having a major role in experiencing HFs. More resources should be directed to develop a unified study system along with multivariable analyses to get a better understanding of this condition, which often imposes a tremendous social and personal toll on the women who experience it.

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“…Some symptoms associated with changing hormone levels are directly linked with estrogen depletion. Hot flashes, night sweats, and vaginal atrophy resulting in vaginal dryness are correlated with changing levels of sex hormones [7] . Other symptoms, such as sleep disturbances, fatigue, anxiety, and weight gain, although common to the experience of menopause, are multi factorial in cause and occur in non-postmenopausal women as well [8] .…”

mentioning

confidence: 99%

Quality of life among menopausal women

Mohamed

Lamadah

Zamil³

2014

Int J Reprod Contracept Obstet Gynecol

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Background: The transition through menopause is a life event that can profoundly affect quality of life. More than 80% of women report physical and psychological symptoms that commonly accompany menopause, with varying degrees of severity and life disruption. Studies find that most women experience at least one or more of these symptoms as they transition through the postmenopausal stage of life. The aim of this study was to assess the menopause related symptoms and their impact on the women's quality of life. Subjects and methods: A descriptive design was carried out in Obstetrics and Gynecological department at maternity and children hospital in Makkah Al Mukkarrmah.. Convenient sample composed of 90 women at range of from 40-60years were recruited in the study. Interviewing sheet that was designed by the investigators and Menopause Specific Quality of Life Questionnaire (MENQOL) were used to collect the data. Results: The present study showed that the most severe symptoms in vasomotor, psychosocial, physical and sexual domains were, hot flushes (29%), experiencing poor memory (48.3%), being dissatisfied with their personal life (44.8%), Low backache (41.9%), and change in your sexual desire (36.8%). The overall scores of menopausal quality of life for each MENQOL domain are indicated that the highest mean score in sexual domain (3.19± 1.99), following by psychosocial (2.94± 1.45) then vasomotor (2.55± 1.53) and finally physical symptoms (2.28± .749). Conclusion: The present study concluded that most severe symptoms in vasomotor, psychosocial, physical and sexual domains were, hot flushes, experiencing poor memory, being dissatisfied with their personal life, low backache, and change in your sexual desire. The mean scores of physical and vasomotor domain were significantly more in postmenopausal (PM) group then menopausal transition MT group. While the mean scores of each domain suggest that menopausal symptoms were associated with decrease in women quality of life. The current study recommended that: Health care providers need to play a more visible and instrumental role in continuously assessing menopausal women's needs as well as implement appropriate health educational programs. Also further research addressing women's health needs is also essential for improving the quality of life of menopausal women in Saudi Arabia Keywords: Menopause -Menopausal symptoms-Quality of life -MENQOL. IntroductionToday, with increasing life expectancy and life span, women spend one-third of their lifetime after menopause [1,2] . Menopause is an adaptation process during which women go through a new biological state. This process is accompanied by many biological and psychosocial changes [3] . Menopause is a normal physiological process which is characterized by the permanent cessation of menses in women as a result of reduced ovarian hormone secretion usually between the ages of 45 and 55 years. During this period women can experience many symptoms including hot flashes, night sweats, sleep and mood disorders, impair...

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A longitudinal study of the predictors of prevalence and severity of symptoms commonly associated with menopause

Cited by 89 publications

References 20 publications

Endogenous hormones, participant characteristics, and symptoms among midlife women

Endogenous hormones, participant characteristics, and symptoms among midlife women

Factors That May Influence the Experience of Hot Flushes by Healthy Middle-Aged Women

Quality of life among menopausal women

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