Recent increases in our awareness to the high prevalence of sleep disorders in general, and of sleepdisordered breathing among children, in particular, has led to concentrated efforts aiming to understand the pathophysiological mechanisms, clinical manifestations and potential consequences of such conditions. In this review, I will briefly elaborate on some of the pathogenetic elements leading to the occurrence of obstructive sleep apnea (OSA) in children, focus on the psychobehavioral consequences of pediatric OSA, and review the evidence on the potential mechanisms underlying the close association between CNS morbidity and the episodic hypoxia and sleep fragmentation that characterize OSA.
Sleep Disorders In ChildrenPediatric sleep continues to gain significant recognition due to both increasing evidence of a high prevalence of sleep disorders among children, and by virtue of the potential somatic and psycho-behavioral effects of disrupted sleep during early development. Obstructive sleep apnea (OSA) is by far the most frequently diagnosed pediatric sleep disorder, and has been reported to affect at least 1-3% of all pre-school and school-aged children. Furthermore, symptoms consistent with an increased risk for sleep-disordered breathing have been reported in 6-27% of children (1-8).