A Longitudinal Study of the Outcome and Associated Factors of Subsyndromal and Syndromal Depression in Community-Dwelling Older Adults with Schizophrenia Spectrum Disorder

Cohen, Carl I.; Ryu, Helen H.

doi:10.1016/j.jagp.2014.06.011

Cited by 27 publications

(19 citation statements)

References 37 publications

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“…On the other hand, other studies did not find a significant impact of these factors, including age (Diwan et al, 2007;Zisook et al, 1999), psychiatric comorbidity (Meesters et al, 2014;Zisook et al, 2007), general medical comorbidity (Cohen and Ryu, 2015;Zisook et al, 1999) and the number and the dose of antipsychotics (Zisook et al, 1999;Zisook et al, 2006). However, this previous research had limited statistical power, as most studies relied on relatively small samples ranging from 60 to 198 older adults with schizophrenia (Cohen and Ryu, 2015;Cohen et al, 1996;Meesters et al, 2014;Zisook et al, 1999;Zisook et al, 2006). Additionally, prior studies were conducted in only three sites (Cohen and Ryu, 2015;Diwan et al, 2007;Meesters et al, 2014;Zisook et al, 2007Zisook et al, , 2006Zisook et al, , 1999, limiting the generalizability of their findings.…”

Section: Introductionmentioning

confidence: 90%

“…Prior research has yielded conflicting evidence on the role of sociodemographic characteristics, psychiatric and other medical conditions and psychotropic medications in the risk of depression among older adults with schizophrenia. Some studies have identified multiple factors associated with depressive symptoms in this population, such as younger age (Cohen and Ryu, 2015;Cohen et al, 1996), psychiatric comorbidity (Zisook et al, 1999;Zisook et al, 2007), general medical comorbidity (Diwan et al, 2007;Meesters et al, 2014), and greater number of psychotropic medications (Cohen and Ryu, 2015). On the other hand, other studies did not find a significant impact of these factors, including age (Diwan et al, 2007;Zisook et al, 1999), psychiatric comorbidity (Meesters et al, 2014;Zisook et al, 2007), general medical comorbidity (Cohen and Ryu, 2015;Zisook et al, 1999) and the number and the dose of antipsychotics (Zisook et al, 1999;Zisook et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have identified multiple factors associated with depressive symptoms in this population, such as younger age (Cohen and Ryu, 2015;Cohen et al, 1996), psychiatric comorbidity (Zisook et al, 1999;Zisook et al, 2007), general medical comorbidity (Diwan et al, 2007;Meesters et al, 2014), and greater number of psychotropic medications (Cohen and Ryu, 2015). On the other hand, other studies did not find a significant impact of these factors, including age (Diwan et al, 2007;Zisook et al, 1999), psychiatric comorbidity (Meesters et al, 2014;Zisook et al, 2007), general medical comorbidity (Cohen and Ryu, 2015;Zisook et al, 1999) and the number and the dose of antipsychotics (Zisook et al, 1999;Zisook et al, 2006). However, this previous research had limited statistical power, as most studies relied on relatively small samples ranging from 60 to 198 older adults with schizophrenia (Cohen and Ryu, 2015;Cohen et al, 1996;Meesters et al, 2014;Zisook et al, 1999;Zisook et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…However, this previous research had limited statistical power, as most studies relied on relatively small samples ranging from 60 to 198 older adults with schizophrenia (Cohen and Ryu, 2015;Cohen et al, 1996;Meesters et al, 2014;Zisook et al, 1999;Zisook et al, 2006). Additionally, prior studies were conducted in only three sites (Cohen and Ryu, 2015;Diwan et al, 2007;Meesters et al, 2014;Zisook et al, 2007Zisook et al, , 2006Zisook et al, , 1999, limiting the generalizability of their findings. Therefore, research using larger samples of older adults with schizophrenia from multiple sites may provide a better knowledge of clinical factors associated with SSSD and improve their early recognition and treatment in this vulnerable population.…”

Section: Introductionmentioning

confidence: 99%

“…Depression is commonly comorbid during the course of schizophrenia. 24% to 48% of older adults with schizophrenia spectrum disorder suffer from syndromal depressive symptoms (Cohen and Ryu, 2015;Diwan et al, 2007;Meesters et al, 2014), and up to 75% of them would suffer from syndromal or subsyndromal depressive symptoms (SSSD) . SSSD are associated with the increase in symptoms of schizophrenia (Cohen, 1995;Cohen et al, 1996;Heila et al, 1997;Jin et al, 2001;Johnson, 1988;Roy, 1981;Zisook et al, 1999;, poorer functional remission Diwan et al, 2007;Limosin, 2009;Meesters et al, 2014;Wetherell et al, 2003), increased risk of suicide (Zisook et al, 2007) and lower quality of life (Cohen et al, 2017;Diwan et al, 2007;Jin et al, 2001;Patterson et al, 1997) among older adults with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

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Subsyndromal and syndromal depressive symptoms among older adults with schizophrenia spectrum disorder: Prevalence and associated factors in a multicenter study

Hoertel¹,

Jaffré²,

Raykeer³

et al. 2019

Journal of Affective Disorders

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Background: Few studies have examined the prevalence and correlates of subsyndromal and syndromal depressive symptoms (SSSD) among older adults with schizophrenia spectrum disorder. In this report, we examined the prevalence of SSSD and their associations with sociodemographic characteristics, clinical characteristics of schizophrenia, comorbidity, psychotropic medications, quality of life, functioning and mental health care utilization in a large, multicenter sample of older adults with schizophrenia spectrum disorder. Methods: Data from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) were used to examine the prevalence of SSSD, defined using the Center of Epidemiologic Studies Depression (CESD) scale. Clinical characteristics associated with SSSD were explored. Results: Among 343 older adults with schizophrenia spectrum disorder, 78.1% had either subsyndromal (30.6%) or syndromal (47.5%) depressive symptoms. SSSD were independently associated with positive and negative symptoms, lower quality of life, non-late-onset psychosis, benzodiazepine use and urbanicity. There were no significant associations of SSSD with other sociodemographic characteristics and psychotropic medications, or with general medical conditions. We found no significant differences in the proportion of participants who were treated with antidepressants between those with syndromal depressive symptoms and those without depression (22.1% vs. 20.0%, p = 0.89). SSSD were not associated with higher mental health care utilization. Limitations: Data were cross-sectional and depression was not evaluated with a semi-structured interview. Conclusion: SSSD may be highly prevalent and under-assessed and/or undertreated among older adults with schizophrenia spectrum disorder. Our findings should alert clinicians about the need to assess systematically and regularly depression in this vulnerable population.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Subsyndromal and syndromal depressive symptoms among older adults with schizophrenia spectrum disorder: Prevalence and associated factors in a multicenter study

Hoertel¹,

Jaffré²,

Raykeer³

et al. 2019

Journal of Affective Disorders

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Late‐onset and nonlate‐onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Kassm

Limosin

Naja

et al. 2021

Int J Geriat Psychiatry

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Objectives Data are scarce regarding the potential clinical differences between non‐late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late‐onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very‐late‐onset schizophrenia‐like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non‐age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross‐sectional multicentre study that recruited in‐ and outpatients older adults (aged ≥55 years) with an ICD‐10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy‐two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p < 0.05). However, the magnitude of these associations was modest, with significant adjusted odds ratios ranging from 0.71 to 1.24, and there were no significant between‐group differences in other characteristics. Conclusion In an age‐matched multicenter sample of elderly patients with schizophrenia, older adults with LOS were largely similar to older adults with NLOS in terms of clinical characteristics. The few differences observed may be at least partially related to symptom fluctuation with time. Implications of these findings for pharmacological and nonpharmacological management is yet to be determined.

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Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients

Fang

Wen

et al. 2022

Eur Arch Psychiatry Clin Neurosci

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A Longitudinal Study of the Outcome and Associated Factors of Subsyndromal and Syndromal Depression in Community-Dwelling Older Adults with Schizophrenia Spectrum Disorder

Cited by 27 publications

References 37 publications

Subsyndromal and syndromal depressive symptoms among older adults with schizophrenia spectrum disorder: Prevalence and associated factors in a multicenter study

Subsyndromal and syndromal depressive symptoms among older adults with schizophrenia spectrum disorder: Prevalence and associated factors in a multicenter study

Late‐onset and nonlate‐onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients

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