A longitudinal study of pulmonary function in coal miners in Lorraine, France

Bates, David V.; Pham, Q T; Chau, Nearkasèn; Pivoteau, Carine; Dechoux, J; Sadoul, P

doi:10.1002/ajim.4700080104

Cited by 17 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results were similar to those observed in previous studies [3]. Longitudinal studies in coal miners have shown that exposure to coal mine dust contributes to a decline in FEV 1 [27,28]. Mamuya et.…”

Section: Discussionsupporting

confidence: 91%

Alterations of serum biomarkers associated with lung ventilation function impairment in coal Workers: A cross-sectional study

Ji-min¹,

Carroll

Liang

et al. 2011

Environ Health

View full text Add to dashboard Cite

BackgroundPrevious studies have demonstrated that alterations in certain circulating biomarkers may be correlated with Coal workers' pneumoconiosis (CWP). This study investigated the relationship between changes of serum biomarkers and pulmonary function during the development of CWP.MethodsLung function parameters and specific serum indices were measured in 69 non-smoking coal workers, including 34 miners with CWP, 24 asymptomatic miners and 11 miners with minimal symptoms. The associations between changes in pulmonary function and serum indices were tested with Pearson's correlation coefficients. Multivariable analysis was used to estimate the predictive power of potential determinant variables for lung function.ResultsCompared to healthy miners, lung function (FVC, FEV1, FEF50, FEF75, FEF25-75 % of predicted values) was decreased in miners with CWP (p < 0.05). Increased serum matrix metalloproteinase-9 (MMP-9) was associated with decreased FVC% of predicted values in the asymptomatic miners (r = -0.503, p = 0.014).ConclusionsIn coal mine workers, alterations of lung function parameters are associated with the development of CWP and with changes in circulating MMP-9, TIMP-9, IL-13 and IL-18R. These serum biomarkers may likely reflect the pathogenesis and progression of CWP in coal workers, and may provide for the importance of serum indicators in the early diagnosis of lung function injury in coal miners.

show abstract

Section: Discussionsupporting

confidence: 91%

Alterations of serum biomarkers associated with lung ventilation function impairment in coal Workers: A cross-sectional study

Ji-min¹,

Carroll

Liang

et al. 2011

Environ Health

View full text Add to dashboard Cite

show abstract

“…As pointed out by Axelson (5), confounding from smoking tends to become more important as the occupational risks tend to decrease. In re-examined subjects, the increase of chronic obstructive disease prevalence and decrease of FEV~.0 were no very important compared to other occupations (3,6,18,28).…”

Section: Discussionmentioning

confidence: 99%

Iron miners ? A ten year follow-up

et al. 1992

Self Cite

View full text Add to dashboard Cite

1167 workers of Lorraine (France) iron mines, a random sample of 5600 workers aged 35 to 55 years, at work in 1975 constituted the initial cohort that was examined twice at 5-year intervals after the first examination. A questionnaire on respiratory symptoms and smoking habits (MRC questionnaire) plus questions on the work history of each participant was completed, vital capacity (VC), forced expiratory volume in one second (FEV1.0), residual volume (RV) and fractional uptake of CO (FuCO) were measured at the first examination and repeated five and ten years later. At the end of the ten year follow-up, 522 subjects were re-examined, 186 were lost to follow-up, 328 answered a mail questionnaire, and 111 had died. The total number of deaths was not different from that of the general population, but for lung cancer the standardized mortality ratio (SMR) was significantly increased (SMR = 3.7). For the miners re-examined, frequency of bronchitis and decrease of functional tests were more related to age and smoking habits than to occupation.

show abstract

“…31 For active non-smoking coal miners, the FEV 1 loss was reported by Bates et al to be around 46 ml/year and that for FVC was around 40 ml/year. 30 Love et al reported that the FEV 1 loss each year for non-smoking coal miners was about 39 ml/year. 40 Our results are consistent with these results.…”

Section: Discussionmentioning

confidence: 99%

Cross sectional study on lung function of coke oven workers: a lung function surveillance system from 1978 to 1990

Kreis

Griffiths³

et al. 2002

Occup Environ Med

View full text Add to dashboard Cite

Aims: To determine the association between lung function of coke oven workers and exposure to coke oven emissions. Methods: Lung function data and detailed work histories for workers in recovery coke ovens of a steelworks were extracted from a lung function surveillance system. Multiple regressions were employed to determine significant predictors for lung function indices. The first sets of lung function tests for 613 new starters were pooled to assess the selection bias. The last sets of lung function tests for 834 subjects with one or more year of coke oven history were pooled to assess determinants of lung function. Results: Selection bias associated with the recruitment process was not observed among the exposure groups. For subjects with a history of one or more years of coke oven work, each year of working in the most exposed "operation" position was associated with reductions in FEV 1 of around 9 ml (p = 0.006, 95% CI: 3 ml to 16 ml) and in FVC of around 12 ml (p = 0.002, 95% CI: 4 ml to 19 ml). Negative effects of smoking on lung function were also observed. Conclusions: Exposure to coke oven emissions was found to be associated with lower FEV 1 and FVC. Effects of work exposure on lung function are similar to those found in other studies.

show abstract

A longitudinal study of pulmonary function in coal miners in Lorraine, France

Cited by 17 publications

References 13 publications

Alterations of serum biomarkers associated with lung ventilation function impairment in coal Workers: A cross-sectional study

Alterations of serum biomarkers associated with lung ventilation function impairment in coal Workers: A cross-sectional study

Iron miners ? A ten year follow-up

Cross sectional study on lung function of coke oven workers: a lung function surveillance system from 1978 to 1990

Contact Info

Product

Resources

About