A longitudinal study of patient- and observer-rated quality of life in schizophrenia

Fitzgerald, Paul B.; Castella, Anthony R.A. de; Filia, Kate; Collins, Jenny; Brewer, Karren; Williams, Chat; Davey, Peter; Kulkarni, Jayashri

doi:10.1016/s0165-1781(03)00099-4

Cited by 56 publications

(38 citation statements)

References 19 publications

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“…Compared to previous research on overall life satisfaction which found that symptoms accounted for less than 10% of the variance in SQOL [22, 26] the current study found that a relatively high proportion of variance in mental health satisfaction (22.5%) was accounted for by affective and negative symptoms. This suggests that when it comes to mental health satisfaction specifically, these two types of symptoms may not only be experienced as most distressing but that their presence may have a considerable influence on patients’ assessments of their mental health.…”

Section: Discussioncontrasting

confidence: 99%

“…Some studies have found negative symptoms to be predictive of SQOL alongside affective symptoms [23], but this link has not been consistently supported across the course of the illness [24] or across studies [25]. For example, a recent study found that when measured by the Positive and Negative Symptoms Scale, negative symptoms were not significantly associated with SQOL [26]. Other research has found that SQOL is better predicted by affective and hostility symptoms than by negative symptoms [22].…”

Section: Discussionmentioning

confidence: 99%

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Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

2018

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Background: The patient’s view of their mental health is a central aspect in research and practice. Yet, little is known about which psychopathological symptoms are linked with patients’ satisfaction with their mental health. We aimed to identify these symptoms in patients with schizophrenia. Methods: An individual patient data meta-analysis was conducted with data from 2,488 patients from 8 independent studies. Satisfaction with mental health was rated on a 7-point scale, and symptoms were observer-rated using identical items from the Brief Psychiatric Rating Scale and the Positive and Negative Symptom Scale. Mixed multilevel univariate followed by multivariate regression models were used to identify symptoms associated with satisfaction with mental health. Results: In univariate regressions, all subscales – not age and gender – were associated with mental health satisfaction. In the multivariate regression, only affective and negative symptoms were significantly associated with a lower satisfaction with mental health, explaining 22.5% of the variance. Conclusions: Observer-rated psychopathological symptoms are linked to patients’ mental health satisfaction. In addition to affective symptoms – which are commonly negatively linked with satisfaction ratings – a higher level of negative symptoms makes patients less satisfied with their mental health, whilst positive and other symptoms do not influence mental health satisfaction.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

2018

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“…It has been shown that depressive symptoms are an important determinant of quality of life in scales that rely on self-assessment, but not in scales completed by an interviewer, as is the case of the QLS-BR. 34,35 Based on simple regression trees, we concluded that cognitive deficit assessed by SCoRS significantly predicted the three factors of the QLS scale and was the only significant predictor of QLS factor 2, occupational level. Negative symptoms assessed by PANSS presented the highest explanatory power for QLS factors 1 and 3, social network and intrapsychic functioning/interpersonal relationship.…”

Section: Discussionmentioning

confidence: 91%

Interview-based assessment of cognition is a strong predictor of quality of life in patients with schizophrenia and severe negative symptoms

Cruz

Resende

Carvalhaes³

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To analyze the correlation between quality of life, symptoms, and cognition assessed by the interview-based Schizophrenia Cognition Rating Scale (SCoRS). Methods: Seventy-nine outpatients diagnosed with schizophrenia were evaluated with the Quality of Life Scale -Brazilian version (QLS-BR), the SCoRS, and symptoms scales (Positive and Negative Syndrome Scale [PANSS]). After determining the potential explanatory variables using Spearman's correlation and Student's t test results, we ran simple, multivariate, and decision-tree regression analyses to assess the impact of SCoRS and PANSS ratings on mean overall quality of life. Results: Cognitive deficits and negative symptoms were the best predictors of quality of life. A low degree of negative symptoms (PANSS negative o 11) was a strong predictor of better quality of life (QLS B 75), regardless of SCoRS rating. Among participants with more severe negative symptoms, elevated cognitive impairment (interviewer SCoRS B 44) was a predictor of worse quality of life (QLS B 44). Conclusions: Cognitive impairment determined by interview-based assessment seems to be a strong predictor of quality of life in subjects with severe negative symptoms. These results support the usefulness of SCoRS for cognitive assessment that is relevant to the everyday life of patients with schizophrenia.

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“…Differences between observer-rated and patient-rated QOL have been described [21] . While self-rated QOL was highly associated with depressive symptoms, observer-rated QOL was associated with negative symptoms as well.…”

Section: Introductionmentioning

confidence: 99%

“…Another reason for the weak association between expert-rated symptoms and QOL might be that longitudinal changes in psychopathology and QOL were considered by few studies so far [15,21,24,28] . Several studies were carried out with outpatient samples, where clinical changes might be less pronounced compared with inpatient samples, and were cross-sectional in design [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

PANSS Syndromes and Quality of Life in Schizophrenia

Karow

Moritz²,

Lambert³

et al. 2005

Psychopathology

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Background: Results from factor analysis studies have suggested that a five-dimensional structure appears to be a better representation of the psychopathological data of the PANSS. The purpose of this study was the detailed investigation of the association of schizophrenia syndromes and single symptoms with quality of life (QOL) in acute and remitted patients. The leading hypotheses were: (1) affective symptoms, especially depression and anxiety, are mostly associated with QOL longitudinally and (2) in the acute phase, QOL is also associated with positive schizophrenia symptoms. Methods: For the present study, schizophrenia and schizophreniform patients were studied on admission, at the end of the acute phase and 6 months after hospitalization. Psychopathology was measured using the PANSS syndromes, QOL was assessed using disease-specific (SWN) and generic (MLDL, EDLQ) scales. Results: Eighty-four patients entered the study and were assessed during the acute phase taking into account their history and actual treatment. Results revealed anxiety as the most important symptom and depression as the most important syndrome associated with different areas of QOL during and after hospitalization. Also cognitive and negative symptoms were associated with different QOL domains, but both positive symptom clusters showed no substantial association with QOL. Conclusions: Results of this longitudinal study investigating psychopathology and QOL in schizophrenia provide further support for the need to consider the psychopathological state and treatment setting when measuring QOL in schizophrenia and the need for a differential analysis of schizophrenia symptoms and QOL in the acute, mid-term and long-term phase. Anxiety reduction should be a critical goal of treatment in order to prevent further QOL impairment.

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A longitudinal study of patient- and observer-rated quality of life in schizophrenia

Cited by 56 publications

References 19 publications

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

Interview-based assessment of cognition is a strong predictor of quality of life in patients with schizophrenia and severe negative symptoms

PANSS Syndromes and Quality of Life in Schizophrenia

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