A Longitudinal Study of Lipid Abnormalities in Renal Failure

Haas, Linda B.; Wahl, Patricia W.; Sherrard, Donald J.

doi:10.1159/000182929

Cited by 20 publications

(8 citation statements)

References 12 publications

(18 reference statements)

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“…Some studies have found positive correlation between hypertriglyceridemia, plasma cholesterol levels and HD duration,[1315] while others have reported a negative correlation. [11] In the present study, we observed a negative correlation between levels of TGs and duration of HD and confirm that long-term HD treatment has no effect on the levels of TGs.…”

Section: Discussionsupporting

confidence: 85%

“…Some studies have reported that lipid and lipoprotein compositions do not appear to be influenced by dialysis duration and no relationship exists between plasma TG levels and dialysis duration,[9–11] whereas others have found correlation between hypertriglyceridemia, cholesterol, lecithin-cholesterol acyltransferase (LCAT) activity and HD duration. [12–15]…”

Section: Introductionmentioning

confidence: 99%

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Coronary risk factors in maintenance hemodialysis patients: Who is the culprit - hemodialysis or chronic renal failure?

Gupta¹,

Mahajan²

2011

Int J App Basic Med Res

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Objective:Dyslipidemia, common in uremic patients subjected to maintenance hemodialysis (HD), represents an independent risk factor for atherosclerosis; but the association between long-term HD and uremic dyslipidemia is not crystal clear. The present study was aimed to ascertain any association.Materials and Methods:The effects of chronic renal failure (CRF) and HD duration on serum lipids, lipoproteins and homocysteine (HC) were studied in 84 patients suffering from CRF subjected to maintenance HD and were compared with 68 healthy, age-, sex- and race-matched control cohorts.Results:Increase in serum free cholesterol (FC), triglycerides, very low-density lipoprotein cholesterol and HC levels, and decrease in esterified cholesterol (EC), EC/FC ratio, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol levels were highly significant (P < 0.001) in pre-dialysis patients compared to controls. Further disturbances were observed (P < 0.05) by repeated HD, resulting in further significant increase in FC, and decrease in EC/FC ratio and HDL-C levels after 40 dialysis schedules.Conclusion:Levels of HDL-C, plasma FC, and ratio of EC/FC appeared to be clearly altered by HD duration, submitting patients to a greater risk of atherosclerosis due to maintenance HD.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Coronary risk factors in maintenance hemodialysis patients: Who is the culprit - hemodialysis or chronic renal failure?

Gupta¹,

Mahajan²

2011

Int J App Basic Med Res

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“…29], Plasma cholesterol and triglyceride con centrations generally remain stable or may decrease slightly over time in long-term he modialysis patients [52][53][54], Apart from slightly higher concentrations of ApoA-I and ApoE, hemodialysis patients appears to have the same qualitative plasma apoiipoprotein profile as patients before dialysis [ 1], In recent years, the treatment with low-molecularweight heparin for anticoagulation has been introduced. Triglyceride levels may be re duced in some hypertriglyceridemic hemodi alysis patients with certain preparations of low-molecular-weight heparin [55].…”

Section: Effects O F Dialysismentioning

confidence: 99%

Diagnosis and Classification of Dyslipidemia in Renal Disease

1996

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Renal disease is accompanied by specific alterations of the lipoprotein metabolism. While marked hyperlipidemia is a characteristic finding in the nephrotic syndrome, the dyslipoproteinemia of renal insufficiency is predominantly reflected in an abnormal apolipoprotein pattern but does not necessarily include elevated plasma lipid concentrations. The specific changes in nephrotic syndrome include increased formation primarily of cholesterol-rich and to a varying extent of triglyc-eride-rich ApoB-containing lipoproteins in the VLDL-LDL density range with little or no change among the ApoA-con-taining lipoproteins in HDL. The dyslipoproteinemia of renal failure is, on the other hand, mainly characterized by a decreased catabolism of the triglyceride-rich ApoB-containing lipoproteins with increased concentrations of partially metabolized lipoproteins of intermediate and very low density and a decreased concentration of ApoA-containing lipoproteins in HDL. In addition, increased levels of Lp(a) are found both in the nephrotic syndrome and in renal failure. Dialysis treatment appears to have only a modest influence on the renal dyslipoproteinemia. Due to its atherogenic character, the dyslipidemia of renal disease may be related to the accelerated development of cardiovascular disease in these patients.

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“…Determination of lipid and apolipoproteins profile in particular of their abnormalities in patients with chronic terminal renal insufficiency (CTRI) in the early stages of the disease, and analysis of ethiopathogenic mechanisms can significantly help in proposing preventive measures (dietary, treatment) with which there will be reduced visible frequent appearance of dyslipidemia, atherosclerotic lesions and reduced incidence of atherosclerosis in patients with CTRI randomized by gender and age (11). Patients with terminal chronic renal failure (TCRF) mostly appear with the type IV type of secondary hyperlipoproteinemia (according to Frederickson's classification) where high concentrations of triglycerides dominates (hypetriglyceridemia values of 28-100%} (12,13). Apolipoprotein-C3 also known as apo-CIII is a protein that in humans is encoded by the Apo-C3 gene.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein c-iii (apo-c3) Metabolism in Patients with End Stage Renal Disease Treated with Long Term Hemodialysis.

Zylbeari

Haxhirexha

Behxheti

et al. 2018

AJTES

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Background: End Stage Renal disease (ESRD) as it was historically termed is a term that encompasses all degrees of decreased renal function, from damaged–at risk through mild, moderate, and severe chronic kidney failure. ESRD is a worldwide public health problem. In the United States, there is a rising incidence and prevalence of kidney failure, with poor outcomes and high cost (see Epidemiology).Material and Methods: The blood sample for routine analysis (lipidogram) and specific analysis was taken at 08o'clock in the morning with the room temperature that variated from 19 to 24°C, before the hemodialysis session, minimum 12 hours of fasting - with tendency to avoid the absorption effect of food by the intestine as well as avoid absorption of lipids and formation of chilomicrones. In all samples regardless of their group, the concentration of ApoC-II and lipids were analyzed in a period of 12 months in a period of 12 months (the measurements were made every three months, it means we totally made 3 measurements in 9 months).Results: The results from patients and controlling group for Apo-C3 and lipid profile (ChT, TG, HDL-ch, LDL-ch) are given in table number 3. A significant statistical difference with p<0.0001 is found from the results of the lipidic profile and ApoC-III of patients with ESRD treated with HD compared with the results of the controlling group for the same parameters.Conclusion: In this study patients with ESRD treated with HD have high parameters of ApoC-III, TG, LDL-ch but low concentrations of HDL-ch due to impaired catabolism of apolipoproteins in this specific group of patients. In all patients symptoms of CDV (myocardial infarction, angina pectoris, ischemia), acute coronary syndrome were noticed.

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A Longitudinal Study of Lipid Abnormalities in Renal Failure

Abstract: From this study of 163 males and 57 females on maintenance dialysis, evidence is presented that lipid levels, except for cholesterol in females, remain stable for the first 5 years. Thus, baseline lipid classifications are valid through this time period.

Cited by 20 publications

References 12 publications

Coronary risk factors in maintenance hemodialysis patients: Who is the culprit - hemodialysis or chronic renal failure?

Coronary risk factors in maintenance hemodialysis patients: Who is the culprit - hemodialysis or chronic renal failure?

Diagnosis and Classification of Dyslipidemia in Renal Disease

Apolipoprotein c-iii (apo-c3) Metabolism in Patients with End Stage Renal Disease Treated with Long Term Hemodialysis.

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