A longitudinal study of autism spectrum disorders in individuals diagnosed with a developmental language disorder as children

Mouridsen, SE; Km, Hauschild

doi:10.1111/j.1365-2214.2009.00954.x

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…Furthermore, DLD is not only heterogeneous in terms of its linguistic profile, but also with respect to co-occurring features, including socio-emotional and behavioral difficulties ( Chow et al, 2018 ; Curtis et al, 2018 ). Of particular relevance to the study presented here is that the prevalence of ASD, and therefore the behavioral symptoms that are associated with ASD, is increased among children with DLD, which appears to be a consistent finding across multiple independent studies ( Conti-Ramsden et al, 2006 ; Leyfer et al, 2008 ; Loucas et al, 2008 ; Miniscalco et al, 2018 ; Mouridsen & Hauschild, 2009 ).…”

Section: Introductionsupporting

confidence: 74%

“…The existing evidence for this hypothesis is mixed, but appears to tend towards no or at most a weak correlation between language difficulties and ASD-related behaviors in DLD. First, and in contrast to the hypothesis mentioned above, a vast number of studies did not detect a relationship between the language abilities and the development of ASD or subthreshold ASD-symptoms in children with DLD (Conti-Ramsden et al, 2006;Howlin et al, 2000;Leyfer et al, 2008;Mouridsen & Hauschild, 2009), nor between language ability and difficulties with peer relationships (Mok et al, 2014). One study showed that receptive language deficits appeared to be negatively associated with the domain measuring 'communication and language' in the Autism Diagnostic Interview (ADI-R), in children with a mixed receptive/expressive language disorder (Mildenberger et al, 2001).…”

Section: Relation Between Language and Asd-related Behaviors In Dldmentioning

confidence: 81%

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Behaviors related to autism spectrum disorder in children with developmental language disorder and children with 22q11.2 deletion syndrome

Selten

Boerma

Everaert

et al. 2023

Autism & Developmental Language Impairments

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Background and Aim. Children with Developmental Language Disorder (DLD) are at an increased risk to develop behaviors associated with Autism Spectrum Disorder (ASD). The relationship between early language difficulties and the occurrence of ASD-related behaviors in DLD is poorly understood. One factor that may hinder progress in understanding this relationship is the etiological heterogeneity of DLD. We therefore study this relationship in an etiologically homogeneous group of children, who share phenotypic characteristics with children with DLD: children with the 22q11.2 Deletion Syndrome (22q11DS). We compare children with 22q11DS, to children with DLD and age-matched typically developing children (TD). Method 44 children with 22q11DS, 65 children with DLD and 81 TD children, between 3.0–6.5 years old, participated in a longitudinal cohort study that included a baseline measure and a follow-up measure with a 1-year interval. A parental questionnaire (SRS-2) was used to measure the incidence of behaviors in two key behavioral domains associated with ASD: Social Communication and Interaction and Restricted Repetitive Behaviors and Interests. At baseline, we assessed children's expressive and receptive language abilities as well as their intellectual functioning with standardized tests. We compared the distribution of ASD-related behaviors between the three groups. We used regression analyses to investigate whether language abilities at baseline predict ASD-related behavior at follow-up, accounting for ASD-related behavior at baseline, demographic variables and intellectual functioning. Results Both the children with 22q11DS and the children with DLD displayed significantly more ASD-related behaviors than the TD children. Over 30% of children in both clinical groups had scores exceeding the subclinical threshold for ASD in both behavioral domains. Both in 22q11DS and DLD, baseline receptive language scores were negatively correlated with ASD-related behaviors 1 year later, when controlling for baseline SRS-scores. However, this association was statistically significant only in children with 22q11DS, even when controlled for IQ-scores, and it was significantly stronger as than in the TD group. The strength of the association did not differ significantly between 22q11DS and DLD. Conclusion Both children with 22q11DS and children with DLD present with elevated rates of ASD-related behaviors at a preschool-age. Only in children with 22q11DS we observed that weaker receptive language skills were related to increased behavioral problems in the domain of social communication and interaction one year later. Implications Our findings indicate that relations between early language impairment and other behavioral phenotypes may be more feasible to detect in a subgroup of children with a homogeneous etiology, than in a group of children with a heterogeneous etiology (such as children with DLD). Our results in 22q11DS reveal that receptive language is especially important in predicting the occurrence of ASD-related behaviors. Future research is needed to determine to what extent receptive language predicts the occurrence of ASD-related behaviors in children with DLD, especially among those children with DLD with the weakest receptive language. Clinically, screening for ASD-related behaviors in children with developmental language difficulties is recommended from a young age, especially among children with receptive language difficulties.

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Section: Introductionsupporting

confidence: 74%

Section: Relation Between Language and Asd-related Behaviors In Dldmentioning

confidence: 81%

Behaviors related to autism spectrum disorder in children with developmental language disorder and children with 22q11.2 deletion syndrome

Selten

Boerma

Everaert

et al. 2023

Autism & Developmental Language Impairments

View full text Add to dashboard Cite

show abstract

“…Adults with Dravet syndrome (Berkvens et al, 2015) and agenesis of the corpus callosum (Paul et al, 2014) had higher autism prevalence than the general population. Preliminary evidence from longitudinal studies suggests an overlap between developmental language disorder (DLD) and autism, as people diagnosed with DLDs in childhood have a higher rate (2.1%) of receiving an autism diagnosis in adolescence and adulthood (Mouridsen & Hauschild, 2009), and 34% of a sample of 38 adults with DLD diagnoses were found to meet autism criteria (Bishop et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Diagnosis of autism in adulthood: A scoping review

Huang

Arnold

Foley

et al. 2020

Autism

140

123

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More adults are undergoing autism assessment due to recent changes in awareness, diagnostic criteria and professional practices. This scoping review aimed to summarise research on autism diagnosis in adulthood and identify any gaps for future study. The authors searched for studies involving first-time assessment and diagnosis of autism in adults, which identified 82 studies from 13 countries using various methodologies. Six themes of (1) prevalence, (2) diagnostic pathways and processes, (3) gender, (4) psychosocial characteristics, (5) co-occurring conditions and (6) experiences of diagnosis were identified across the studies. Findings suggest that receiving an autism diagnosis has a significant emotional impact on adults, but accessibility and processes are inconsistent, and formal support services are lacking. More research is needed on autism diagnosis in adults with intellectual disability, consequences of the timing of diagnosis, and support after diagnosis. Lay abstract More adults are getting assessed for possible autism. Here, we give an overview on what is already known about autism diagnosis in adulthood and find areas that need more research. We divided results from the studies we found into six topics of (1) rates of autism in different groups; (2) the process of getting an autism diagnosis in adulthood; (3) gender; (4) personality traits, abilities and behaviours of diagnosed adults; (5) mental and physical health conditions that occur together with autism; and (6) how adults think and feel about being assessed and diagnosed. We found that adults often have strong emotions after being diagnosed, the process of getting a diagnosis can be unclear and different for everyone, and not many support services are available for adults. More research on diagnosing adults with intellectual disability, differences between early and late-diagnosed adults, and support after diagnosis would be useful.

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“…More data is needed to disambiguate ASD from other symptomologies, especially when diagnosed early. A longitudinal study found that of 469 Danish people diagnosed with a developmental language delay as children, 10 later carried a diagnosis of ASD in adulthood (Mouridsen & Hauschild, 2009). Deficits in social gestures may provide an extra indicator in these ambiguous situations.…”

Section: Importance Of Studying Giving and Showing In Diagnosismentioning

confidence: 99%

Beyond Pointing: Development of the "Showing" Gesture in Children with Autism Spectrum Disorder

Clements¹,

Chawarska²

2010

PsycEXTRA Dataset

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A longitudinal study of autism spectrum disorders in individuals diagnosed with a developmental language disorder as children

Abstract: Our results provide additional support to the notion that DLD is a marker of increased vulnerability to the development of ASD.

Cited by 9 publications

References 20 publications

Behaviors related to autism spectrum disorder in children with developmental language disorder and children with 22q11.2 deletion syndrome

Behaviors related to autism spectrum disorder in children with developmental language disorder and children with 22q11.2 deletion syndrome

Diagnosis of autism in adulthood: A scoping review

Beyond Pointing: Development of the "Showing" Gesture in Children with Autism Spectrum Disorder

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