A longitudinal observational study in two cats naturally-infected with hepadnavirus

Capozza, Paolo; Lanave, Gianvito; Diakoudi, Georgia; Stasi, Fabio; Ghergo, Paola; Ricci, Dominga; Santo, Giacinto; Arena, Gianluca; Grillo, Isidoro; Donne, Elisabetta Delle; Lisio, Francesca Di; Zini, Eric; Callegari, Carolina; Valente, Luca; Camero, Michele; Martino, Barbara Di; Beatty, Julia A.; Barrs, Vanessa R.; Buonavoglia, Canio; Martella, Vito

doi:10.1016/j.vetmic.2021.108999

Cited by 21 publications

(39 citation statements)

References 19 publications

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“…Following the initial study, a longitudinal observation of two DCH-positive cats for 4.5 months or 11 months, respectively, demonstrated that DCH infections can be chronic, which is similar to HBV infections in humans (Capozza et al, 2021). Moreover, a persistent alanine aminotransferase (ALT) elevation was also documented, which is an indication of liver diseases.…”

Section: Italymentioning

confidence: 94%

“…Unlike HBV, which can be transmitted to other cats through blood, skin, and other bodily fluids, including serum, saliva, and semen through sexual or maternal route (Bancroft et al, 1977;Scott et al, 1980;Hou et al, 2005), DCH has only been detected in serum, whole blood, heart, lungs, intestines, kidneys, and spleen (Aghazadeh et al, 2018;Lanave et al, 2019;Piewbang et al, 2020;Anpuanandam et al, 2021). A longitudinal observation of two cats naturally infected with DCH showed that repeated PCR assays of oral, conjunctival, preputial, and rectal swabs were negative for DCH (Capozza et al, 2021). However, the fact that the DCH genome was detected in the blood suggests that it was potentially transmitted to other cats through blood.…”

Section: Route Of Dch Infection and Transmissionmentioning

confidence: 99%

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Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

et al. 2022

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Hepatitis B is an infectious hepatocellular disease of global concern caused by hepatitis B virus (HBV), which belongs to Hepadnaviridae. Recently, a novel HBV-like virus, domestic cat hepadnavirus (DCH), was detected from an immunocompromised cat with a hepatic disease in Australia. Subsequent molecular investigation by independent research groups revealed that its prevalence rates were 6.5% in Australia, 10.8% in Italy, 12.4% in Thailand, 12.3% in Malaysia, 3.08% in the United Kingdom, and 0.78% in Japan. Although the correlation between DCH infection and hepatic diseases remains to be elucidated, understanding the diversity of circulating DCH will contribute to its prevention and control in domestic cats. Herein, we summarize the current epidemiological data of DCH in these countries.

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Section: Italymentioning

confidence: 94%

Section: Route Of Dch Infection and Transmissionmentioning

confidence: 99%

Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

et al. 2022

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“…Since feline retroviruses cause impairment of the immune system [ 7 , 8 ], the detection of DCH in cats with retroviral infection could be related to the immunocompromised status, as observed for HBV [ 24 , 25 ]. The transmission of HBV in humans occurs through blood and other body fluids, including serum, saliva, and semen, and transmission can also occur during sexual contacts and by maternal/fetal route [ 17 , 26 ]. Transmission of FIV/FeLV in cats occurs with similar modalities, as the virus is present in blood and body fluids [ 7 , 8 , 9 ].…”

Section: Domestic Cat Hepadnavirus (Dch)mentioning

confidence: 99%

“…Transmission of FIV/FeLV in cats occurs with similar modalities, as the virus is present in blood and body fluids [ 7 , 8 , 9 ]. Since DCH can be detected in serum and whole blood samples [ 18 , 20 , 21 , 22 ], similar modalities of transmission might also be hypothesized for DCH transmission [ 20 , 26 ]. However, in a longitudinal observational study in two cats naturally co-infected with DCH and feline retroviruses, oral, conjunctival, preputial, and rectal swabs repeatedly tested negative to DCH [ 26 ].…”

Section: Domestic Cat Hepadnavirus (Dch)mentioning

confidence: 99%

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Emerging Hepatotropic Viruses in Cats: A Brief Review

Capozza

Decaro

Beikpour

et al. 2021

Viruses

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The possible role of viruses in feline liver disease has long remained neglected. However, in 2018, an analogue of human hepatitis B virus was identified in cats. Moreover, antibodies for human hepatitis E have been detected consistently at various prevalence rates in cats. Although the correlation between these viruses and the liver injury in cats must be clarified, hepatotropic viruses might represent an increasing risk for feline and public health.

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Evaluating the presence of domestic cat hepadnavirus viraemia in cats with biochemical alterations suggestive of liver disease

et al. 2022

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Background The association between domestic cat hepadnavirus (DCH) infection and feline chronic hepatitis and hepatocellular carcinoma has been suggested. However, studies focused on the association between DCH infection and clinicopathological changes consistent with liver disease in cats are not available. Methods This retrospective investigation included sera obtained from 96 cats that had the serum activity of at least alanine aminotransferase or alkaline phosphatase measured during initial diagnostic work‐up. Based on these haematobiochemical results, cats were categorised according to their likelihood of having liver disease (absent, low, intermediate or high). DCH DNA was detected using real‐time PCR, nested PCR and sequencing. Results Overall, potential liver damage was observed in 44 cats, including cats with low (n = 14), intermediate (n = 10) and high (n = 20) likelihood of liver disease. Four cats (4.2%) were DCH‐positive, with three positive cats belonging to the liver disease group (two with low and one with intermediate likelihood of liver disease). Conclusions Although the pathogenic potential of DCH in cats still has to be clarified, these results suggest that DCH testing should not be based only on the presence of biochemical changes potentially consistent with liver disease.

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A longitudinal observational study in two cats naturally-infected with hepadnavirus

Cited by 21 publications

References 19 publications

Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

Global Prevalence of Domestic Cat Hepadnavirus: An Emerging Threat to Cats’ Health?

Emerging Hepatotropic Viruses in Cats: A Brief Review

Evaluating the presence of domestic cat hepadnavirus viraemia in cats with biochemical alterations suggestive of liver disease

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