A longitudinal mixed methods study on changes in body weight, body composition, and lifestyle in breast cancer patients during chemotherapy and in a comparison group of women without cancer: study protocol

Kruif, J.Th.C.M. de; Visser, Marjolein; Berg, M.M.G.A. van den; Derks, M.; Boer, Michiel R. de; Laarhoven, Hanneke W. M. van; Vries, J.H.M. de; Kampman, Ellen; Winkels, R.; Westerman, Marjan J.

doi:10.1186/s12885-018-5207-7

Cited by 13 publications

(11 citation statements)

References 70 publications

(54 reference statements)

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“…The collection and analysis of qualitative and quantitative data will be carried out separately, and the findings will be compared and consolidated at the interpretation phase. By combining quantitative results obtained from the measurements and questionnaires with qualitative results obtained from individual interviews and focus groups, we will be able to get a more complete and comprehensive evaluation of the implementation [ 21 , 22 ]. Triangulation will be used to explore if outcomes provide similar (complementary) or different (contradictory) findings [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

StayBalanced: implementation of evidence-based fall prevention balance training for older adults—cluster randomized controlled and hybrid type 3 trial

Halvarsson

Roaldsen

Nilsén

et al. 2021

Trials

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Background The StayBalanced programme has shown positive effects on fall prevention, balance control and fear of falling. Despite convincing evidence on the efficacy and effectiveness of balance training, there is a gap between research findings and what is provided in community-based and clinical health care settings. Therefore, transferring evidence-based balance training into clinical practice is needed. Methods This project, designed as a hybrid type 3 trial, is a cluster-randomized study with a mixed-method design, carried out in primary health care settings. The aim is to investigate the effectiveness of two different strategies to facilitate the implementation of an intervention, the StayBalanced balance training programme, in primary health care, including evaluation of relative changes and maintenance in patient outcomes between intervention arms over 24 months. The StayBalanced programme will be launched through a website with information on the balance training and how to use it in clinical practice. One implementation strategy will include close facilitation, i.e. support and close follow-ups initiated by the researchers, in addition to access to the website. The other strategy simply includes access to the StayBalanced website. Outcome measures in the project consist of implementation outcomes, such as acceptability, feasibility, fidelity and sustainability of the StayBalanced programme. Outcomes at an individual level for older adults participating in the training will include fall-related concerns, health-related quality of life, balance performance, gait, physical activity, muscle strength in lower extremities, number of falls and compliance with training. Discussion This study will generate new understanding of effective strategies for transferring research to clinical practice and thereby reduce an important knowledge gap, as well as aid decision-making for future implementation of evidence-based methods. Furthermore, it will contribute to improved balance and gait, increased level of physical activity and function, and improved health-related quality of life for the individuals participating in the programme. Trial registration ClinicalTrials.govNCT02909374. Registered on September 21, 2016

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Section: Methodsmentioning

confidence: 99%

StayBalanced: implementation of evidence-based fall prevention balance training for older adults—cluster randomized controlled and hybrid type 3 trial

Halvarsson

Roaldsen

Nilsén

et al. 2021

Trials

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“…On the other hand, breast cancer patients who are receiving chemotherapy experience symptoms such as a loss of appetite, as well as changes in body weight and body composition, which could potentially increase the risk of cancer recurrence, cardiovascular disease and diabetes (de Kruif et al . ). In this sense, exercise has been suggested to reduce cancer recurrence and cancer‐related mortality (Ghose et al .…”

Section: Introductionmentioning

confidence: 97%

Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats

Moreira

Almeida

Franco

et al. 2019

The Journal of Physiology

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Key pointsr Cancer growth, cell proliferation and cachexia index can be attenuated by the beneficial programming effect of moderate exercise training, especially if it begins in adolescence.r Walker 256 tumour-bearing rats who started exercise training during adolescence did not revert the basal low glycaemia and insulinaemia observed before tumour cell inoculation.r The moderate exercise training improved glucose tolerance and peripheral insulin sensitivity only in rats exercised early in adolescence.r The chronic effects of our exercise protocol are be beneficial to prevent cancer cachexia and hold clear potential as a nonpharmacological therapy of insulin sensitization.Veridiana Mota Moreira has worked in higher education as an effective member of a research ethics committee, a co-ordinator of physical activity and health research laboratories, an editor and reviewer in major scientific journals, a professor in Physical Education, and in Nursing, Biology and Physiotherapy Degree Courses. She has supervised and co-ordinated monographs and internships in Physical Education. She has participated in a high-performance soccer team as a physiologist. She participates in the Developmental Origins of Health and Disease (DOHaD) research group at the Laboratory of Cellular Biology of Secretion co-ordinated by Paulo Cezar de Freitas Mathias. In the future, she intends to study the application of molecular biology techniques associated with cancer, aiming to understand the multiplicity of cellular networks involved in the response to physical training, providing mechanisms by which the muscular system communicates with other organs, and mediating the beneficial effects of physical exercise related to health at different ages. * These authors contributed equally to this work. AbstractWe tested the hypothesis that moderate exercise training, performed early, starting during adolescence or later in life during adulthood, can inhibit tumour cell growth as a result of changes in biometric and metabolic markers. Male rats that were 30 and 70 days old performed a treadmill running protocol over 8 weeks for 3 days week -1 , 44 min day -1 and at 55-65%V O 2 max . After the end of training, a batch of rats was inoculated with Walker 256 carcinoma cells. At 15 days after carcinoma cell inoculation, the tumour was weighed and certain metabolic parameters were evaluated. The data demonstrated that physical performance was better in rats that started exercise training during adolescence according to the final workload andV O 2 max . Early or later moderate exercise training decreased the cachexia index, cell proliferation and tumour growth; however, the effects were more pronounced in rats that exercised during adolescence. Low glycaemia, insulinaemia and tissue insulin sensitivity was not reverted in Walker 256 tumour-bearing rats who trained during adolescence. Cancer growth can be attenuated by the beneficial programming effect of moderate exercise training, especially if it begins during adolescence. In addition, improvement in glu...

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“…Although effective in increasing muscle strength, less evidence supports the use of RT when looking at body composition [ 204 ]. To describe in detail the potential effects of PA in BC changes, the COBRA study (Change Of Body composition in Breast cancer: All-in Assessment-study) used a mixed methods designs to obtain both quantitative measures of changes in body weight, body composition, as well as lifestyle factors and qualitative assessments of women´s perceptions, compared with non-cancer women [ 205 ]. Adapted exercises and physiotherapy intervention could also be associated with enhanced shoulder ROM (Range of Movement), a common BC complication after surgery [ 206 , 207 ].…”

Section: Pa In Bc Managementmentioning

confidence: 99%

Physical Activity as an Imperative Support in Breast Cancer Management

Ortega

Fraile-Martínez

García-Montero

et al. 2020

Cancers

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Breast cancer (BC) is the most common malignancy and the second cause of cancer-related death among women. It is estimated that 9 in 10 cases of BC are due to non-genetic factors, and approximately 25% to 30% of total breast cancer cases should be preventable only by lifestyle interventions. In this context, physical activity represents an excellent and accessible approach not only for the prevention, but also for being a potential support in the management of breast cancer. The present review will collect the current knowledge of physical activity in the background of breast cancer, exploring its systemic and molecular effects, considering important variables in the training of these women and the evidence regarding the benefits of exercise on breast cancer survival and prognosis. We will also summarize the various effects of physical activity as a co-adjuvant therapy in women receiving different treatments to deal with its adverse effects. Finally, we will reveal the impact of physical activity in the enhancement of quality of life of these patients, to conclude the central role that exercise must occupy in breast cancer management, in an adequate context of a healthy lifestyle.

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A longitudinal mixed methods study on changes in body weight, body composition, and lifestyle in breast cancer patients during chemotherapy and in a comparison group of women without cancer: study protocol

Cited by 13 publications

References 70 publications

StayBalanced: implementation of evidence-based fall prevention balance training for older adults—cluster randomized controlled and hybrid type 3 trial

StayBalanced: implementation of evidence-based fall prevention balance training for older adults—cluster randomized controlled and hybrid type 3 trial

Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats

Physical Activity as an Imperative Support in Breast Cancer Management

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