“…[781 antialgesic drug, suprofen, has been shown to relieve the chronic musculoskeletal pain of osteoarthritis [38,39], a severe condition involving considerable pain and inflammation. Postoperative dental pain is thought to be mediated by products of the cyclooxygenase pathway; and some results [40], showing that aspirin (600 or 1200 rag) is active in relieving pain after removal of impacted lower third molars, are compatible with this hypothesis.…”