A Long Term Double-Blind Clinical Trial of Ibuprofen and Indomethacin in Rheumatoid Arthritis

Royer, George; Moxley, T. E.; Hearron, Martha S.; Miyara, A; Shenker, B M

doi:10.1177/030006057500300304

Cited by 17 publications

(7 citation statements)

References 4 publications

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“…Ibuprofen is a 2-phenylalkanoic acid derivative which is among the most commonly prescribed NSAIDs, indicated for analgesia, gout, osteoarthritis, and other rheumatic diseases (Flower et al, 1985;Kantor, 1979;Royer et al, 1975;Schweitz et al, 1978). Based on the data of previous published reports on the instability of the arylacetic acids to the light (Givens and Levi, 1979;Meiggs et al, 1972;Epling and Lopes, 1977), Ibuprofen, by reasons of chemical analogy, should be photolabile.…”

Section: Discussionmentioning

confidence: 99%

PHOTOLYTIC DEGRADATION OF IBUPROFEN. TOXICITY OF THE ISOLATED PHOTOPRODUCTS ON FIBROBLASTS and ERYTHROCYTES

Castell

Gomez-L.

Miranda

et al. 1987

Photochem & Photobiology

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The photodegradation of Ibuprofen, a widely used non‐steroidal anti‐inflammatory drug (NSAID), was examined. Several photoproducts (I‐VI) were isolated and identified on the basis of their IR‐1H‐NMR‐ and 13C‐NMR‐ spectra. The chemical structures were confirmed by unambiguous alternative synthesis from available reagents. The most significant primary photochemical process was the cleavage of the C‐C bond a to the carboxy group. Subsequent secondary processes (hydrogen abstraction, dimerization, incorporation of methanol, or reaction with oxygen) might account for the formation of the different photoproducts. The cytotoxic effects were assayed using the red‐blood cell lysis test and the enzyme leakage (LDH and GOT) from cultured fibroblasts. Compound V [l‐(4 isobutylphenyl)‐ethanol] was found to be toxic for both system at concentrations greater than 1 mM while compound IV [l‐(4 isobutylphenyl acetophenone)] was toxic for fibroblasts but not for erythrocytes at the same concentration. Ibuprofen and the other photocompounds were apparently non‐toxic. The significance of these results is discussed in connection with the possible in vivo phototoxicity of Ibuprofen.

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Section: Discussionmentioning

confidence: 99%

PHOTOLYTIC DEGRADATION OF IBUPROFEN. TOXICITY OF THE ISOLATED PHOTOPRODUCTS ON FIBROBLASTS and ERYTHROCYTES

Castell

Gomez-L.

Miranda

et al. 1987

Photochem & Photobiology

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“…(1) Overall degree of pain assessed on a 10 em visual analogue scale (VAS) from 'no pain at all' (0) to pain 'as bad as it can be' (10).…”

Section: Resultsmentioning

confidence: 99%

Mefenamic acid versus ibuprofen in osteoarthritis — a double‐blind cross‐over study

Barnard-Jones¹,

Davies

Lalla³

et al. 1986

Int J Clinical Practice

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One hundred and seventeen patients with osteoarthritis of the hip and/or knee were entered into this double-blind cross-over study of mefenamic acid and ibuprofen. Following a one week washout period, patients received either 1500 mg mefenamic acid or 1800 mg ibuprofen daily for four weeks. After a second, one-week washout period the patients were crossed over to the other active treatment for a further four weeks. Mefenamic acid was statistically significantly more effective in relieving pain at night of the affected joint. Of the 77 per cent of patients who expressed a preference for one or other of the medications, 64 per cent preferred mefenamic acid. Fifteen patients reported 19 adverse events while taking ibuprofen compared with only nine patients who reported 10 events while taking mefenamic acid.

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“…Underdosing was a problem in many of the early evaluations of ibuprofen where daily doses of 1,600 mg or less were used (12). We believe, however, that 2,400 mg daily should have been adequate to produce antiinflammatory effects, as have been demonstrated at that dose with rheumatoid arthritis (13), osteoarthritis (14), and gout (15). Not only was ibuprofen demonstrated to be less effective than aspirin, but it was found to be as toxic.…”

Section: Discussionmentioning

confidence: 99%

Comparative effects of aspirin and ibuprofen in the management of systemic lupus erythematosus

Karsh¹,

Kimberly²,

Stahl³

et al. 1980

Arthritis & Rheumatism

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A Long Term Double-Blind Clinical Trial of Ibuprofen and Indomethacin in Rheumatoid Arthritis

Cited by 17 publications

References 4 publications

PHOTOLYTIC DEGRADATION OF IBUPROFEN. TOXICITY OF THE ISOLATED PHOTOPRODUCTS ON FIBROBLASTS and ERYTHROCYTES

PHOTOLYTIC DEGRADATION OF IBUPROFEN. TOXICITY OF THE ISOLATED PHOTOPRODUCTS ON FIBROBLASTS and ERYTHROCYTES

Mefenamic acid versus ibuprofen in osteoarthritis — a double‐blind cross‐over study

Comparative effects of aspirin and ibuprofen in the management of systemic lupus erythematosus

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