A Long Surviving Case of Gastric Cancer with Liver Metastasis and Portal Vein Thrombus Successfully Treated by Surgical Resection after S-1 and CDDP Chemotherapy

Nishino, Hiroto; Sasaki, Ben; Asao, Yoshito; Furuyama, Hiroaki; Yoshimura, Tsunehiro

doi:10.5833/jjgs.2014.0065

Cited by 6 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a treatment strategy, systemic chemotherapy is generally recommended for gastric cancer with distant metastasis or PVTT. Whereas it is difficult to discuss the treatment strategy for extrahepatic bile duct cancer with PVTT because few cases have been reported previously [ 14 , 15 ], some papers reported long-term survival after resection of gastric cancer with PVTT following systemic chemotherapy [ 16 , 17 ]. Waseda et al reported that chemotherapy should be conducted at first even if gastric cancer with PVTT is considered resectable because PVTT is a poor prognostic factor [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Gastric cancer simultaneously complicated with extrahepatic bile duct metastasis and portal vein tumor thrombus: a case report

Otsuka,

Nakagawa,

Uchinami

et al. 2023

surg case rep

View full text Add to dashboard Cite

Background Gastric cancer metastatic to the extrahepatic bile duct or accompanied by portal vein tumor thrombus (PVTT) is rare. To our knowledge, there have been no cases complicated with both of these factors. Case presentation A 72-year-old man presented with icterus and melena. A biochemical blood test showed abnormal values for hepatobiliary enzymes and a tumor marker, and abdominal computed tomography scan revealed wall thickening of the lower bile duct with intra- and extra-hepatic bile duct dilatation and PVTT. A biopsy of the lower bile duct during endoscopic retrograde cholangiopancreatography demonstrated a moderately differentiated tubular adenocarcinoma. Moreover, gastroduodenoscopy showed a type 3 tumor at the lesser curvature of the gastric antrum, and an endoscopic biopsy demonstrated a moderately differentiated tubular adenocarcinoma. We diagnosed concomitant gastric cancer and distal bile duct accompanied by PVTT, and pancreatoduodenectomy with combined resection of the portal vein was performed. The resected specimen revealed a tumor in the lesser curvature of the gastric antrum and circumferential wall thickening in the lower bile duct. In pathological findings, infiltration of a moderately differentiated tubular adenocarcinoma from the mucosal layer to the subserosal layer of the stomach was observed. In contrast, a moderately differentiated tubular adenocarcinoma demonstrating the same histological type as the gastric cancer had spread not to the mucosal layer but mainly to the fibromuscular layer of the lower bile duct. Immunohistochemical staining showed identical patterns between gastric cancer and the bile duct tumor: negativity for cytokeratin 7 (CK7), and positivity for CK19 and 20. Therefore, the final diagnosis was extrahepatic bile duct metastasis from gastric cancer with PVTT. Unfortunately, multiple liver metastases occurred in the early postoperative period and chemotherapy was conducted, but the patient died 12 months after the surgery. Conclusions In the diagnosis of extrahepatic bile duct metastasis, immunohistochemical staining of gastric cancer and the bile duct tumor was essential and helpful as decisive evidence.

show abstract