A Long Survival Case of Metachronous Cerebellar Metastasis that was caused by Gastric Cancer

Matsubara, Taketo; Yoshizawa, Yasuo; Sasaya, Shoji; Sakuraba, Kazuma; Shirahata, Atsushi; Gotoh, Tetsuhiro; Maezawa, Koji; Shimada, Mitsuo; Nemoto, Hiroshi; Yukitoshi, Sanada

doi:10.5833/jjgs.41.76

Cited by 3 publications

(5 citation statements)

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“…5,7) Brain metastases from gastric cancer are often presented in the cerebrum, whereas exclusive cerebellar metastases are rare. 9,10) Most of the brain metastases from gastric cancer are detected at an advanced stage, 5) and result in poor prognosis with a median overall survival (OS) of 2.0–9.1 months. 4,5,9,11) Regarding early gastric cancer, it is defined as invasive gastric cancer that invades no more deeply than the submucosa, regardless of LN metastases.…”

Section: Discussionmentioning

confidence: 99%

“…9,10) Most of the brain metastases from gastric cancer are detected at an advanced stage, 5) and result in poor prognosis with a median overall survival (OS) of 2.0–9.1 months. 4,5,9,11) Regarding early gastric cancer, it is defined as invasive gastric cancer that invades no more deeply than the submucosa, regardless of LN metastases. 8) To the best of our knowledge, there have only been a few reports of exclusive brain metastases from early gastric cancer, 9) and there are no prior reports of exclusive cerebellar metastases from early gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…4,5,9,11) Regarding early gastric cancer, it is defined as invasive gastric cancer that invades no more deeply than the submucosa, regardless of LN metastases. 8) To the best of our knowledge, there have only been a few reports of exclusive brain metastases from early gastric cancer, 9) and there are no prior reports of exclusive cerebellar metastases from early gastric cancer. In the present case, we clinically diagnosed the patient as having exclusive metastatic cerebellar tumors from gastric cancer without other metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Table 1 shows the clinical characteristics of case with exclusive cerebral and/or cerebellar metastases from gastric cancer reported in Japan. 9,10,12–16) We reviewed only Japanese gastric cancer cases because of the following reasons: abundant clinical data are available due to high incidence rate of gastric cancer in Japanese; gastric cancer is histologically classified according to the Japanese Classification of Gastric Carcinoma 8) ; and the Japanese people have relatively high genetic homogeneity. 17) To the best of our knowledge, there have been 28 cases [23 males and 5 females, median age 68 (ranging between 30 and 83) years old] including the present case, from 1989 to 2017.…”

Section: Discussionmentioning

confidence: 99%

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Exclusive Cerebellar and Leptomeningeal Metastases from Early Gastric Cancer 14 Months after Proximal Gastrectomy: An Autopsy Case Report

Murakami

Kobayashi

Naruse

et al. 2019

NMC Case Report Journal

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We report a rare autopsy case in which the patient received gastrectomy after an endoscopic diagnosis of early gastric cancer, and had deteriorated due to exclusive metastatic cerebellar tumors identified 14 months after surgery. A 65-year-old male was diagnosed as having a 0-IIc-type early gastric cancer on the posterior wall of the upper stomach by gastrointestinal endoscopy in search of a cause of epigastralgia, and thus received proximal gastrectomy and pyloroplasty. Although the tumor was in the early stages and limited within the mucosal layer, adjuvant chemotherapy was started by using S-1 80 mg daily due to evidence of metastasis into lymph node #3 at the lesser curvature. Evidence of both recurrence and metastases was not detected by CT scans of the chest, abdomen, and pelvis, and the chemotherapy was completed 12 months after surgery. However, the patient was admitted to hospital 14 months postoperatively due to dizziness and gait disturbance. Cranial MRI (Magnetic Resonance Imaging) revealed multiple tumors in the bilateral cerebellar hemispheres with additional leptomeningeal involvement. The patient died 2 weeks after admission. An autopsy revealed metastatic cerebellar tumors and leptomeningeal lesions from the early gastric cancer, and obstructive hydrocephalus due to metastatic cerebellar tumors. To our knowledge, this case is the first report of metastasis exclusive to the cerebellum and leptomeninges from early gastric cancer limited to the mucosal layer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Exclusive Cerebellar and Leptomeningeal Metastases from Early Gastric Cancer 14 Months after Proximal Gastrectomy: An Autopsy Case Report

Murakami

Kobayashi

Naruse

et al. 2019

NMC Case Report Journal

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“…We summarize 20 published surgical cases, including these reports from Japan and our case (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) (Table I). Metastatic foci were surgically resected and histologically confirmed as metastases in all of these patients.…”

Section: Discussionmentioning

confidence: 99%

Five-year Survival After Surgical Removal and Gamma Knife Stereotactic Radiosurgery for a Cerebellar Metastasis from an Esophagogastric Junction Cancer: A Case Report and Literature Review

Kanazawa

Fujita

Kakinuma

et al. 2017

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Abstract. Brain Brain metastases from esophageal or gastric cancer account for approximately 2.1-3.3% of all brain tumors registered in Japan (1). Their prognosis is poor because there are no established therapeutic strategies (2). Here, we report a patient who survived for 5 years after treatment of a solitary cerebellar metastasis from cancer of the esophagogastric junction (EGJ) and review published case reports. Case ReportThe patient, a 74-year-old woman who was 159.5 cm tall and weighed 45.5 kg, was diagnosed with advanced EGJ cancer and underwent total gastrectomy with splenectomy and D2 lymph node dissection. After an uncomplicated postoperative period, the patient was discharged from hospital on postoperative day 12. The primary EGJ cancer was diagnosed as Siewert type II, type 3 by pathological examination of the excised surgical specimen. Findings included type 3, tumor size 70 × 50 mm, moderately differentiated tubular adenocarcinoma, ss, ly1, v2, two lymph node metastases, and stage IIB according to the Japanese Classification of Gastric Carcinoma (3) (Figures 1 and 2). Six weeks postoperatively, the patient commenced adjuvant chemotherapy with 120 mg/kg of S-1. However, she developed grade 2 anorexia and systemic malaise according to Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 (4), and therefore discontinued this treatment after 2 weeks, refused alternative chemotherapy and was only followed-up. 1209

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Successful Multidisciplinary Treatment for Multiple Gastric Cancer with a Simultaneous Solitary Cerebral Metastasis: A Case Report

Fukushima

Shimizu

Yamaguchi

et al. 2022

Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi

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A Long Survival Case of Metachronous Cerebellar Metastasis that was caused by Gastric Cancer

Cited by 3 publications

References 0 publications

Exclusive Cerebellar and Leptomeningeal Metastases from Early Gastric Cancer 14 Months after Proximal Gastrectomy: An Autopsy Case Report

Exclusive Cerebellar and Leptomeningeal Metastases from Early Gastric Cancer 14 Months after Proximal Gastrectomy: An Autopsy Case Report

Five-year Survival After Surgical Removal and Gamma Knife Stereotactic Radiosurgery for a Cerebellar Metastasis from an Esophagogastric Junction Cancer: A Case Report and Literature Review

Successful Multidisciplinary Treatment for Multiple Gastric Cancer with a Simultaneous Solitary Cerebral Metastasis: A Case Report

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