A local circadian clock for memory?

Lehr, Andrew B.; McDonald, Robert J.; Thorpe, Christina M.; Tetzlaff, Christian; Deibel, Scott H.

doi:10.1016/j.neubiorev.2020.11.032

Cited by 7 publications

(6 citation statements)

References 95 publications

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“…This extended synaptic potentiation prompts homeostatic constraints to gradually increase as the day progresses (Fernandes & Carvalho, 2016), which would consequently increase the amount of anterograde interference. Based on the SYH, a resulting hypothesis is that the amount of anterograde interference becomes increasingly important over a wake period (Lehr et al, 2021); if confirmed by future studies, this would further support the interpretation that homeostatic constraints drive anterograde interference. Importantly, here, participants were systematically tested at the same time of day, which makes it unlikely that these considerations can bias the interpretation of the present results.…”

Section: Discussionmentioning

confidence: 77%

“…Given that anterograde interference is expected to emerge as a function of the overlap in learning‐specific neural networks, it was hypothesized that the A → A, A′ → A and α → A conditions would, respectively , generate meaningful (Cohen's d z of ~.8), modest (Cohen's d z of ~.5) and negligible (Cohen's d z of ~.3) amounts of anterograde interference. Finally, it is worthy to note that each session occurred at the same time of day to control for circadian influences on learning capabilities (Frank, 2016; Lehr et al, 2021) and at least 24 h separated each session.…”

Section: Introductionmentioning

confidence: 99%

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Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study

Hamel

Lepage

Bernier

2021

Eur J of Neuroscience

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Anterograde interference emerges when two opposite (B → A) or identical tasks (A → A) are learned in close temporal succession, suggesting that interference cannot be fully accounted for by competing memories. Informed by neurobiological evidence, this work tested the hypothesis that interference depends upon the degree of overlap between the neural networks involved in the learning of two tasks. In a fully within‐subject and counterbalanced design, participants (n = 24) took part in two learning sessions where the putative overlap between learning‐specific neural networks was behaviourally manipulated across four conditions by modifying reach direction and the effector used during gradual visuomotor adaptation. The results showed that anterograde interference emerged regardless of memory competition—that is, to a similar extent in the B → A and A → A conditions—and along a gradient as a function of the tasks' similarity. Specifically, learning under similar reaching conditions generated more anterograde interference than learning under dissimilar reaching conditions, suggesting that putatively overlapping neural networks are required to generate interference. Overall, these results indicate that competing memories are not the sole contributor to anterograde interference and suggest that overlapping neural networks between two learning sessions are required to trigger interference. One discussed possibility is that initial learning modifies the properties of its neural networks to constrain further plasticity induction and learning capabilities, therefore causing anterograde interference in a network‐dependent manner. One implication is that learning‐specific neural networks must be maximally dissociated to minimize the interfering influences of previous learning on subsequent learning.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study

Hamel

Lepage

Bernier

2021

Eur J of Neuroscience

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“…On the contrary, it does appear that a bias for synaptic inhibition in the dentate gyrus occurs with circadian arrhythmicity ( McMartin et al, 2021 ). But it remains to be seen if this applies to the current data because our animals remained rhythmic during the T21, they were just not entrained to the light dark cycle ( Ruby et al, 2008 ; Fernandez et al, 2014 ; Shimizu et al, 2016 ; Kwapis et al, 2018 ; Hasegawa et al, 2019 ; Lehr et al, 2021 ).…”

Section: Discussionmentioning

confidence: 81%

“…Since observation of diurnal variations in both human, and rodent memory, circadian rhythms and memory have received much attention ( Eckel-Mahan and Storm, 2009 ; Smarr et al, 2014 ; Krishnan and Lyons, 2015 ; Rawashdeh et al, 2018 ; Snider et al, 2018 ; Hartsock et al, 2020 ; Lehr et al, 2021 ). A common question is whether manipulating circadian rhythms impairs memory.…”

Section: Introductionmentioning

confidence: 99%

“…Much research has been devoted to understanding why memory might be impaired from different types of circadian rhythm disruption. Molecules involved in synaptic plasticity oscillate in the hippocampus and are influenced by clock genes ( Rawashdeh et al, 2018 ; Snider et al, 2018 ; Hartsock et al, 2020 ; Lehr et al, 2021 ). We know that hippocampal clock gene expression is essential for memory retention ( Shimizu et al, 2016 ; Kwapis et al, 2018 ; Hasegawa et al, 2019 ; Hartsock et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression

Deibel¹,

Higdon²,

Cassell³

et al. 2022

Front. Behav. Neurosci.

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Circadian rhythms influence virtually all aspects of physiology and behavior. This is problematic when circadian rhythms no longer reliably predict time. Circadian rhythm disruption can impair memory, yet we don’t know how this fully works at the systems and molecular level. When trying to determine the root of a memory impairment, assessing neuronal activation with c-FOS is useful. This has yet to be assessed in the hippocampi of circadian rhythm disrupted rats in a hippocampal gold standard task. Rats were trained on the Morris water task (MWT), then received 6 days of a 21-h day (T21), 13 days of a normal light dark cycle, probe trial, and tissue extraction an hour later. Despite having impaired memory in the probe trial, compared to controls there were no differences in c-FOS expression in hippocampal sub regions: CA1; CA3; Dentate gyrus. These data confirm others in hamsters demonstrating that arrhythmicity which produces an impairment in spontaneous alternation does not affect c-FOS in the dentate gyrus. The current study indicates that the memory impairment induced by a lighting manipulation is likely not due to attenuated neuronal activation. Determining how the master clock in the brain communicates with the hippocampus is needed to untangle the relationship between circadian rhythms and memory.

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Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance

Lei,

Hua,

et al. 2023

Arch Toxicol

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A local circadian clock for memory?

Cited by 7 publications

References 95 publications

Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study

Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study

Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression

Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance

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