1987
DOI: 10.2170/jjphysiol.37.995
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A local anesthetic, tetracaine, similarly inhibits Ag+ and K+ contractures in frog skeletal muscle.

Abstract: To evaluate usefulness of Ag+ contracture as a tool for elucidating the mechanism underlying the excitation-contraction coupling, the effects of tetracaine on Ag + contracture were compared with those on K + and caffeine contractures in frog skeletal muscle. Tetracaine less than 100 /1M shortened the duration of 120 mM K+ contracture, without affecting tension amplitude. At higher concentrations of tetracaine, K + contracture was inhibited dose-dependently and the duration shortened. Treatment of the fibers wi… Show more

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