A living electrode construct for incorporation of cells into bionic devices

Goding, Josef; Robles, Ulises Aregueta; Poole-Warren, Laura A.; Lovell, Nigel H.; Martens, Penny J.; Green, Rylie A.

doi:10.1557/mrc.2017.44

Cited by 39 publications

(33 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, this hydrogel and crosslinking system would not be recommended for supporting large scale tissue scaffolds (on the order of millimetres). However, for neural tissue engineering approaches, such electrode coatings that aim to enhance the neural interface, the expected thickness of a cell carrier is less than 100 µm. In these conditions, limitations on polymerization due to light attenuation are not significant.…”

Section: Resultsmentioning

confidence: 99%

Tailoring 3D hydrogel systems for neuronal encapsulation in living electrodes

Aregueta‐Robles

Martens

Poole-Warren

et al. 2017

J Polym Sci B Polym Phys

View full text Add to dashboard Cite

State‐of‐the‐art neurorprostheses rely on stiff metallic electrodes to communicate with neural tissues. It was envisioned that a soft, organic electrode coating embedded with functional neural cells will enhance electrode‐tissue integration. To enable such a device, it is necessary to produce a cell scaffold with mechanical properties matched to native neural tissue. A degradable poly(vinyl alcohol) (PVA) hydrogel was tailored to have a range of compressive moduli through variation in macromer composition and initiator amount. A regression model was used to predict the amount of initiator required for hydrogel polymerization with nominal macromer content ranging between 5 and 20 wt %. Hydrogels at 5 and 10 wt % were reliably formed but 15 wt % and above were not able to be fabricated due to the light attenuation properties of the initiator ruthenium at increased concentration. Compressive modulus of hydrogels decreased upon incorporation of biomolecules (sericin and gelatin), however, the bulk stiffness spanned the range required to match neural tissue properties (0.04–20kPa). Neuroglia cells, such as Schwann cells survived and grew within the scaffold. The significant finding of this work is that the PVA‐tyramine system can be tuned to provide a soft degradable scaffold for neural tissue regeneration while presenting bioactive molecules for cellular expansion. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 273–287

show abstract

Section: Resultsmentioning

confidence: 99%

Tailoring 3D hydrogel systems for neuronal encapsulation in living electrodes

Aregueta‐Robles

Martens

Poole-Warren

et al. 2017

J Polym Sci B Polym Phys

View full text Add to dashboard Cite

show abstract

“…More importantly, it is not only necessary to use surface-modifying materials for improved electrical properties of the electrode surface, but it is also desirable to develop electrodes that could maintain long-term cell viability and support tissue regeneration. In this context, many studies have recently proposed the concept of incorporating living cells onto electrode surfaces [61][62][63].…”

Section: Challenges In Implantable Bio-electronic Chipsmentioning

confidence: 99%

Graphene Oxide–Based Nanomaterials: An Insight into Retinal Prosthesis

Yang

Cheng

et al. 2020

IJMS

View full text Add to dashboard Cite

Retinal prosthesis has recently emerged as a treatment strategy for retinopathies, providing excellent assistance in the treatment of age-related macular degeneration (AMD) and retinitis pigmentosa. The potential application of graphene oxide (GO), a highly biocompatible nanomaterial with superior physicochemical properties, in the fabrication of electrodes for retinal prosthesis, is reviewed in this article. This review integrates insights from biological medicine and nanotechnology, with electronic and electrical engineering technological breakthroughs, and aims to highlight innovative objectives in developing biomedical applications of retinal prosthesis.

show abstract

“…Hence further improvements are needed to improve the cell-device adhesion with coatings or encasing hydrogels. [53] Incorporation of a hydrogel layer may increase the mechanical compliance of the microelectrodes implanted [45] and degradable hydrogels encasing cells may allow for ECM regeneration at site of lesion. There have been promising approaches to date for the field of bioelectronics using a biohybrid approach to achieve repair of lost CNS communications, although further in vivo chronic studies are needed to assess biocompatibility and survival of transplanted cells over time.…”

Section: Cell-seeded Probesmentioning

confidence: 99%

When Bio Meets Technology: Biohybrid Neural Interfaces

et al. 2019

View full text Add to dashboard Cite

The development of electronics capable of interfacing with the nervous system is a rapidly advancing field with applications in basic science and clinical translation. Devices containing arrays of electrodes can be used in the study of cells grown in culture or can be implanted into damaged or dysfunctional tissue to restore normal function. While devices are typically designed and used exclusively for one of these two purposes, there have been increasing efforts in developing implantable electrode arrays capable of housing cultured cells, referred to as biohybrid implants. Once implanted, the cells within these implants integrate into the tissue, serving as a mediator of the electrode–tissue interface. This biological component offers unique advantages to these implant designs, providing better tissue integration and potentially long‐term stability. Herein, an overview of current research into biohybrid devices, as well as the historical background that led to their development are provided, based on the host anatomical location for which they are designed (CNS, PNS, or special senses). Finally, a summary of the key challenges of this technology and potential future research directions are presented.

show abstract

A living electrode construct for incorporation of cells into bionic devices

Cited by 39 publications

References 33 publications

Tailoring 3D hydrogel systems for neuronal encapsulation in living electrodes

Tailoring 3D hydrogel systems for neuronal encapsulation in living electrodes

Graphene Oxide–Based Nanomaterials: An Insight into Retinal Prosthesis

When Bio Meets Technology: Biohybrid Neural Interfaces

Contact Info

Product

Resources

About