A little night(PA)CAP: pituitary adenylate cyclase-activating polypeptide mediates behavioral effects of alcohol withdrawal

Pirino, Breanne E.; Barson, Jessica R.

doi:10.1038/s41386-020-00922-2

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Studies have also shown that the pituitary adenylate cyclase-activating polypeptide (PACAP) in the bed nucleus of the stria terminalis is related to alcohol dependence and involved in the formation of negative emotional states during withdrawal; it also induces binge drinking after withdrawal. Therefore, drugs that interfere with PACAP can effectively treat AWS and have the potential for clinical application [13]. In conclusion, as candidates for the targeted treatment of alcohol withdrawal, these drugs require further clinical research to confirm their safety and clinical effectiveness.…”

Section: Medicine Advancesmentioning

confidence: 99%

“…Alcohol addiction is considered a mental disorder caused by chronic alcohol consumption, which is characterized by uncontrolled alcohol use and alcohol-seeking behavior. As alcohol consumption can eliminate aversive withdrawal-related states, it is generally assumed that the mechanism of alcohol addiction is motivated by negative reinforcement rather than positive reinforcement [13]. The underlying neural mechanism of alcohol dependence is related to the loss of brain reward system function and the recruitment of extended stress systems in the amygdala [14].…”

Section: Alcohol Abuse and Addictionmentioning

confidence: 99%

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From consumption to withdrawal: A broad synopsis of the effects of alcohol

Zhu,

Liu,

Kong

et al. 2023

Medicine Advances

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The consumption of alcohol reflects both societal norms and personal choices and has major clinical implications. Long‐term excess alcohol consumption leads to a domino effect of pathological outcomes and onset of chronic illness. However, the risks of alcohol consumption extend beyond long‐term health issues. Because habitual alcohol drinkers reach a state of systemic homeostasis, when they attempt withdrawal, they experience many negative physiological effects and may develop alcohol withdrawal syndrome. The complex interplay between alcohol consumption and withdrawal does not result solely in behavioral issues. Rather, a substantial number of important physiological adaptations and potential problems underly habitual drinking. Addressing these issues requires comprehensive medical observation and intervention. Here, we summarize the pathophysiological mechanisms, clinical diseases, and related treatment methods of alcohol consumption and withdrawal. The aim was to provide a reference to improve understanding of alcohol use and promote an informed approach to alcohol withdrawal.

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Section: Medicine Advancesmentioning

confidence: 99%

Section: Alcohol Abuse and Addictionmentioning

confidence: 99%