A Literature‐Based Update on <i>Benincasa hispida</i> (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Islam, Muhammad Torequl; Quispe, Cristina; El‐Kersh, Dina M.; Shill, Manik Chandra; Bhardwaj, Kanchan; Bhardwaj, Prerna; Sharifi‐Rad, Javad; Martorell, Miquel; Hossain, Rajib; Al‐Harrasi, Ahmed; Al‐Rawahi, Ahmed; Butnariu, Monica; Rotariu, Lia Sanda; Suleria, Hafiz Ansar Rasul; Taheri, Yasaman; Docea, Anca Oana; Calina, Daniela; Cho, William C.

doi:10.1155/2021/6349041

Cited by 29 publications

(23 citation statements)

References 85 publications

(121 reference statements)

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“…There is proof that the usage of natural compounds originating from microbes, animals, or plants for medical purposes goes back to the Neanderthal epoch [114,115]. People have gathered knowledge and become an expert in their applications due to various biological activities of isolated natural items [116][117][118]. The invention of the chemical structure aided the manufacturing of the essential compounds rather than separating them from natural sources [119].…”

Section: Discussionmentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are altered in a variety of diseases, including cancer. Extant studies on the homeostatic and pathologic behavior of MAPK signaling have been conducted; however, much remains to be explored in preclinical and clinical research in terms of regulation and action models. MAPK has implications for cancer therapy response, more specifically in response to experimental MAPK suppression, compensatory mechanisms are activated. The current study investigates MAPK as a very complex cell signaling pathway that plays roles in cancer treatment response, cellular normal conduit maintenance, and compensatory pathway activation. Most MAPK inhibitors, unfortunately, cause resistance by activating compensatory feedback loops in tumor cells and tumor microenvironment components. As a result, innovative combinatorial treatments for cancer management must be applied to limit the likelihood of alternate pathway initiation as a possibility for generating novel therapeutics based on incorporation in translational research. We summarize current knowledge about the implications of ERK (MAPK) in cancer, as well as bioactive products from plants, microbial organisms or marine organisms, as well as the correlation with their chemical structures, which modulate this pathway for the treatment of different types of cancer.

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Section: Discussionmentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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“…Cardioprotection refers to all systems and methods that help keep the heart healthy by decreasing or even preventing myocardial damage [ 103 ]. U. dioica water and petroleum ether extract at, respectively, 20 and 150 mg/kg/day improved blood lipid level in rats, decreased blood cholesterol levels and LDL/HDL lipoprotein ratios after 30 days.…”

Section: Pharmacological Activities Of the Genus Urticamentioning

confidence: 99%

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Taheri

Quispe

Herrera‐Bravo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Urtica dioica belongs to the Urticaceae family and is found in many countries around the world. This plant contains a broad range of phytochemicals, such as phenolic compounds, sterols, fatty acids, alkaloids, terpenoids, flavonoids, and lignans, that have been widely reported for their excellent pharmacological activities, including antiviral, antimicrobial, antihelmintic, anticancer, nephroprotective, hepatoprotective, cardioprotective, antiarthritis, antidiabetic, antiendometriosis, antioxidant, anti-inflammatory, and antiaging effects. In this regard, this review highlights fresh insight into the medicinal use, chemical composition, pharmacological properties, and safety profile of U. dioica to guide future works to thoroughly estimate their clinical value.

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“…The secondary metabolites can be broadly classified into alkaloids, terpenes, flavonoids, lignans, steroids, curcumins, saponins, phenolics, and glucosides [ 16 ]. These secondary metabolites, either in individuals or in a group can be used for designing personalized cancer prevention programs as these plants based bioactive compounds present much required geno-protective effects such as DNA damage protection in healthy cells [ 17 – 19 ] .…”

Section: Introductionmentioning

confidence: 99%

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

et al. 2022

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Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.

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A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Cited by 29 publications

References 85 publications

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

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