A Liquid Ventilator Prototype for Total Liquid Ventilation Preclinical Studies

Micheau, Philippe; Robert, Raymond; Beaudry, Benoit; Beaulieu, A.; Nadeau, Mathieu; Avoine, Olivier; Rochon, Marie-Eve; Praud, Jean‐Paul; Walti, Hervé

doi:10.5772/21490

Cited by 7 publications

(1 citation statement)

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“…Such pressure, although decreasing rapidly within the ventilator circuit and subsequently in the proximal airways, may contribute to the fluctuation documented in systemic arterial blood pressure [ 5 , 7 ] and other hemodynamic variables. For example, using the INOLIVENT prototype, it was shown that for an inspiratory pressure of 90 cmH 2 O measured proximally to the endotracheal tube, the pressure at the distal end of the tube had already dropped to 30 cmH 2 O while ventilating with perflubron [ 15 ] (pressure measurement sites shown in Fig 1 ).…”

Section: Introductionmentioning

confidence: 99%

Assessing the impacts of total liquid ventilation on left ventricular diastolic function in a model of neonatal respiratory distress syndrome

et al. 2018

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BackgroundFilling the lung with dense liquid perfluorocarbons during total liquid ventilation (TLV) might compress the myocardium, a plausible explanation for the instability occasionally reported with this technique. Our objective is to assess the impacts of TLV on the cardiovascular system, particularly left ventricular diastolic function, in an ovine model of neonatal respiratory distress syndrome.MethodEight newborns lambs, 3.0 ± 0.4 days (3.2 ± 0.3kg) were used in this crossover experimental study. Animals were intubated, anesthetized and paralyzed. Catheters were inserted in the femoral and pulmonary arteries. A high-fidelity pressure catheter was inserted into the left ventricle. Surfactant deficiency was induced by repeated lung lavages with normal saline. TLV was then conducted for 2 hours using a liquid ventilator prototype. Thoracic echocardiography and cardiac output assessment by thermodilution were performed before and during TLV.ResultsLeft ventricular end diastolic pressure (LVEDP) (9.3 ± 2.1 vs. 9.2 ± 2.4mmHg, p = 0.89) and dimension (1.90 ± 0.09 vs. 1.86 ± 0.12cm, p = 0.72), negative dP/dt (-2589 ± 691 vs. -3115 ± 866mmHg/s, p = 0.50) and cardiac output (436 ± 28 vs. 481 ± 59ml/kg/min, p = 0.26) were not affected by TLV initiation. Left ventricular relaxation time constant (tau) slightly increased from 21.5 ± 3.3 to 24.9 ± 3.7ms (p = 0.03). Mean arterial systemic (48 ± 6 vs. 53 ± 7mmHg, p = 0.38) and pulmonary pressures (31.3 ± 2.5 vs. 30.4 ± 2.3mmHg, p = 0.61) were stable. As expected, the inspiratory phase of liquid cycling exhibited a small but significant effect on most variables (i.e. central venous pressure +2.6 ± 0.5mmHg, p = 0.001; LVEDP +1.18 ± 0.12mmHg, p<0.001).ConclusionsTLV was well tolerated in our neonatal lamb model of severe respiratory distress syndrome and had limited impact on left ventricle diastolic function when compared to conventional mechanical ventilation.

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Section: Introductionmentioning

confidence: 99%