A Liquid Chromatography/Mass Spectrometry System Providing Continuous Monitoring with Nanogram Sensitivity

Arpino, Patrick; Dawkins, Bobby G.; McLafferty, Fred W.

doi:10.1093/chromsci/12.10.574

Cited by 98 publications

(17 citation statements)

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“…The basic research conducted in universities during the 1970s and 1980s marked the conception stage of LC/MS methods. For example, the fundamentals of interfacing an HPLC with a mass spectrometer were studied (Arpino et al, 1974;Carroll et al, 1975;Arpino, 1982) and mechanisms of ionization were characterized (Thomson and Iribarne, 1979;Blakely et al, 1980;Whitehouse et al, 1985). The validation stage of the analytical method represents the convergence of interest among research, instrumentation, and potential application.…”

Section: Partnerships and Acceptancementioning

confidence: 99%

LC/MS applications in drug development

Lee¹,

Kerns²

1999

Mass Spectrom. Rev.

385

297

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At many times during this project I found myself asking the question,"Why am I doing this?" In my attempt to answer, I would always seem to recount my positive experiences with the analytical sciences. Thus, I feel compelled to give thanks to those who were integral to my education in the analytical sciences and inspirations to my professional development. First, I thank the University of Maryland for encouraging me to pursue an education in the sciences. Second, I thank the graduate program at the University of Florida for providing me an opportunity to focus in the analytical sciences and teaching me how to formulate question and thought. Third, I thank Bristol-Myers Squibb for balancing my hunger for the application of analytical sciences with the need to experience collaboration, interaction, and growth. To each of the above mentioned institutions, I am grateful for the support and continued source of inspiration. To all the people at the above mentioned institutions, I will hold dear the friendships, relationships, and memories that are the result of success and failure. And finally, I wish to thank my loving wife and family for their continual encouragement and support for everything I do. For this, I am truly blessed. xii ACKNOWLEDGMENTS CHAPTER 1 1

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Section: Partnerships and Acceptancementioning

confidence: 99%

LC/MS applications in drug development

Lee¹,

Kerns²

1999

Mass Spectrom. Rev.

385

297

View full text Add to dashboard Cite

show abstract

“…The conception stage of LC/MS methods was emphasized during the 1970's± 80's via basic research conducted in universities. For example, the fundamentals of interfacing an HPLC with a mass spectrometer were studied (Arpino et al, 1974;Carroll et al, 1975;Arpino, 1982) and mechanisms of ionization were characterized (Thomson & Iribarne, 1979;Blakely et al, 1980;Whitehouse et al, 1985). The validation stage of the analytical method represents the convergence of interest among research, instrumentation, and potential application.…”

Section: Partnerships and Acceptancementioning

confidence: 99%

LC/MS Applications in Drug Development

Lee¹

2002

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“…Recent developments for the difficult problem of interfacing h.p.l.c. to the mass spectrometer (also providing means for rapid routine introduction of solid samples in solution) are the endless belt (McFadden et al 1976), (b) the direct introduction method described by Baldwin & McLafferty (1973 a, b )and Arpino et al (1974), (c) the modified membrane separato described by Jones & Yang (1975) and…”

Section: (G) Pyrolysis Mass Spectrometrymentioning

confidence: 99%

Mass spectrometry instrumentation for chemists and biologists

1979

Phil. Trans. R. Soc. Lond. A

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Like Gaul, a mass spectrometer may be divided into three parts: source, analyser and detector system. The status of each is reviewed. Recent developments concerning the ion source region include improved techniques for chemical ionization (c.i.), field desorption (f.d.) and negative ion formation. There has also been significant work with pyrolysis probes, high pressure liquid chromatography (h.p.l.c.) interfaces and improved fast pumping for use with atmospheric pressure ionization (a.p.i.) and direct coupling of capillary column gas chromatographs. Commonly used analysers are now either the quadrupole r.f. filter or single/double focusing magnetic deflexion instruments. Magnetic instrument developments reviewed include improvements to sensitivity (Z-focusing and image curvature correction), higher scan speeds (laminated magnets), mass indication and marking, peak jumping when using multiple ion detection (m.i.d.) and reverse geometries (permitting mass analysed ion kinetic energy spectroscopy; MIKES) and linked scan (providing metastable ion information). Detection systems are discussed in detail and include consideration of computer data acquisition and display. Important are simultaneous foreground/background systems, library search, wide dynamic range, precision mass measurement at low resolution (higher sensitivity) and multiple ion detection at either low or high resolution. The use of linked scan and MIKES as specific ion detectors is considered.

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A Liquid Chromatography/Mass Spectrometry System Providing Continuous Monitoring with Nanogram Sensitivity

Cited by 98 publications

References 0 publications

LC/MS applications in drug development

LC/MS applications in drug development

LC/MS Applications in Drug Development

Mass spectrometry instrumentation for chemists and biologists

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