A Lipid-Soluble Ginseng Extract Inhibits Human Large Cell Lung Cancer (NCI-H460) Cells Xenograft In Vivo and the Proliferation of Cancer Cells In Vitro

Lipid-Soluble Ginseng Extract Induces Apoptosis and G0/G1 Cell Cycle Arrest in NCI-H460 Human Lung Cancer Cells

“…GI 50 value of LSGE for NCI-H460 cells was 81.04 μg/ml. This result was consistent with our previous studies [13,14], showing that LSGE inhibited proliferation of a variety of cancer cells including the human lung (NCI-H460, GI 50 =90.4 μg/ml), gastric (MKN74, GI 50 =28.2 μg/ ml), prostate (PC-3, 28.5 μg/ml), liver (HepG2, GI 50 = 21.1 μg/ml), and breast (MCF-7, GI 50 =41.2 μg/ml) cancer cell lines. Cancer cell lines displayed different sensitivities to natural products with anticancer activity due to their different histological types [14].…”

“…This result was consistent with our previous studies [13,14], showing that LSGE inhibited proliferation of a variety of cancer cells including the human lung (NCI-H460, GI 50 =90.4 μg/ml), gastric (MKN74, GI 50 =28.2 μg/ ml), prostate (PC-3, 28.5 μg/ml), liver (HepG2, GI 50 = 21.1 μg/ml), and breast (MCF-7, GI 50 =41.2 μg/ml) cancer cell lines. Cancer cell lines displayed different sensitivities to natural products with anticancer activity due to their different histological types [14]. Because lung cancer is the leading cause of cancer-related deaths worldwide [18] and non-small cell lung cancer constitutes~85% of all human lung cancer cases [19], there are many efforts to find potent anticancer agents against the human non-small cell lung tumor from natural sources.…”

“…Because lung cancer is the leading cause of cancer-related deaths worldwide [18] and non-small cell lung cancer constitutes~85% of all human lung cancer cases [19], there are many efforts to find potent anticancer agents against the human non-small cell lung tumor from natural sources. In our previous reports, LSGE exhibited significant anticancer effects against the human non-small cell lung (NCI-H460) cancer cells in vitro and in vivo [13,14]. LSGE at the concentrations of 30 and 100 μg/ml was used in all further experiments for elucidating its anticancer mechanism in NCI-H460 human lung cancer cells.…”

“…In our previous report, the content of polyacetylenes in LSGE was considered to be 2.38~6.88% and panaxynol was identified as a dominant compound [13]. Also, LSGE possessed an anticancer activity against NCI-H460 human lung tumors in murine xenograft models in a dose-dependent manner without any apparent sign of toxicity [13,14]. Although the anticancer activity of LSGE was reported to be derived from G1 cell cycle arrest [15], little is known regarding the molecular mechanism of LSGE-induced anticancer effects.…”

Lipid-Soluble Ginseng Extract Inhibits Invasion and Metastasis of B16F10 Melanoma Cells

“…7,8,14,15 In particular, the anticancer activity of ginseng was reported to originate mainly from lipid-soluble components. 7 Since LSGE contained a very small amount of ginsenosides and no polysaccharides, it was assumed that the antitumor effect of LSGE is due to nonpolar components such as polyacetylenes and polyphenolics.…”