A lipid/PLGA nanocomplex to reshape tumor immune microenvironment for colon cancer therapy
Nan Zhang,
Qiqi Sun,
Junhua Li
et al.
Abstract:Immune checkpoint blockade therapy provides a new strategy for tumor treatment, however, the insufficient infiltration of cytotoxic T cells and immunosuppression in tumor microenvironment lead to unsatisfied effects. Herein, we reported a lipid/PLGA nanocomplex (RDCM) co-loaded with the photosensitizer Ce6 and the indoleamine 2,3-dioxygenase (IDO) inhibitor 1MT to improve immunotherapy of colon cancer. Arginine-glycine-aspartic acid (RGD) as the targeting moiety was conjugated on 1,2-distearoyl-snglycero-3-pho… Show more
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