A Link Between Inflammatory Mechanisms and Fibromyalgia

Bains, Ashika; Kohrman, Samuel; Punko, Diana; Fricchione, Gregory L.

doi:10.1007/978-981-19-7376-5_16

Cited by 6 publications

(5 citation statements)

References 66 publications

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“…Confirming the effect of the oloproteic diet on alleviating inflammatory conditions in the gut, treatment with the oloproteic diet leads to notable improvements in these symptoms, with reductions of 59.1% in cystitis and 50.01% in vaginal discharge. Improvement in these symptoms was accompanied by a significant decrease in dysbiosis biomarkers in urine (including hydroxyvalerate, valerate, citrulline, and TMAO) [ 57 , 58 , 59 ] and saliva (glycolate and urea) [ 60 , 61 ] ( Figure 2 B,C, Tables S2 and S3 ).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Effectiveness of a Carb-Free Oloproteic Diet in Fibromyalgia Treatment

Castaldo,

Marino,

Atteno

et al. 2024

Nutrients

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Fibromyalgia (FM), a chronic disease with a high incidence in women, poses a significant challenge for diagnosis and treatment, especially due to the absence of specific biomarkers and the multifaceted nature of its symptoms, which range from neuromuscular pain to mood disorders and intestinal dysbiosis. While diagnosis currently relies on rheumatological clinical evaluations and treatment options mainly focus on symptom management, FM seems to have possible links with systemic metabolic dysfunctions with a common inflammatory root. In this context, a new therapeutic avenue emerges: could a therapeutic nutritional approach be the missing piece of the puzzle? Indeed, diet therapies employed particularly for metabolic syndromes proved recently to be efficacious for correcting systemic dysmetabolism and a high number of chronic inflammation conditions. In particular, the very-low-calorie ketogenic diet (VLCKD) demonstrated therapeutic benefits in many disorders. In the present study, we aimed to investigate the specific effects of two dietary interventions, namely the oloproteic VLCKD and the low-glycemic insulinemic (LOGI) diet, on two groups of female FM patients (FM1 and FM2) over a 45-day period. Utilizing clinical and laboratory tests, as well as non-invasive NMR metabolomic analysis of serum, urine, and saliva samples, we sought to uncover how these dietary regimens impact the metabolic dysfunctions associated with FM.

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Section: Discussionmentioning

confidence: 99%

Investigating the Effectiveness of a Carb-Free Oloproteic Diet in Fibromyalgia Treatment

Castaldo,

Marino,

Atteno

et al. 2024

Nutrients

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“…Inflammation of the nervous system is thought to be a potential cause of FM, and pro-inflammatory cytokines such as IL-6, IL-8 are increased in FM patients relative to healthy controls. 8 Immune cells can act as mediators in the development of inflammation, 9 for example macrophages in muscle have been shown to contribute to the development of chronic muscle pain. 10 Pro-inflammatory cytokines can activate and sensitize injury receptors, induce pain and trigger nociceptive sensitization.…”

Section: Introductionmentioning

confidence: 99%

The Role and Potential Mechanism of Complement Factor D in Fibromyalgia Development

Lei,

Song,

Fan

et al. 2023

JPR

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Purpose Fibromyalgia (FM) is a syndrome characterized by chronic musculoskeletal pain. Its clinical symptoms include both somatic and psychiatric symptoms, making the treatment of FM extremely challenging. The cause of FM is still unknown, and some patients do not improve their symptoms even after long-term active treatment. Thus, the development of new targeted therapies is important to reduce pain and improve quality of life for FM patients. Methods In this study, we screened genes and secreted factors that play key roles in FM through bioinformatics and big data analysis. Furthermore, we performed CCK-8, qRT-PCR, glucose, ATP and lactate content testing, dual luciferase reporter gene assay to investigate the potential mechanism of complement factor D in fibromyalgia development. Results In bioinformatics and big data analysis, we identified CFD was negatively correlated with the pro-inflammatory factor IL-6 and positively correlated with the anti-inflammatory factor IL-4, which suggested that CFD may be an anti-inflammatory factor. Through cellular assays, we verified that CFD reversed the decrease in IL-4 expression and the increase in IL-6 expression in BV2 cells caused by ATP. Conclusion In summary, based on bioinformatic methods and big data mining we obtained a new target CFD for FM, and further experiments verified that CFD has significant inhibition of ATP-induced neuropathic pain. These findings provide a new theoretical basis for the clinical translation of CFD.

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“…In addition, imprecise analytical methods, and the lack of consideration of possible proinflammatory factors such as obesity or smoking should be taken into account. The introduction of highly sensitive CRP assays (hsCRP) now makes it possible to detect even subtle inflammatory activity ( 9 ), including subclinical processes ( 22 ), which may shed light on the underlying mechanisms of fibromyalgia. This now makes it possible to overcome possible biases in previous studies and to re-examine the significance of hsCRP in patients with FMS.…”

Section: Introductionmentioning

confidence: 99%

“…Due to a high involvement of stress in the pathogenesis of FMS, biomarkers have become a focus of research. These biomarkers include stress associated markers as for example cortisol, catecholamines as (nor-)epinephrine, adrenocorticotrophin releasing hormone (ACTH), and corticotropin releasing hormone (CRH), but also inflammatory immune cytokines such as IL-6 or IL-8 and c-reactive protein (CRP) (7)(8)(9). Until today, the evidence of the involvement of those markers in the pathogenesis and development of FMS is not clarified.…”

Section: Introductionmentioning

confidence: 99%

“…The current evidence is heterogenous, some studies show elevated marker concentrations in individuals with FMS and some studies appear to find the opposite. Due to the involvement of some of those markers in the inflammation processes of the body and in pain processes, a relation between FMS and its symptoms with pro-inflammatory cytokines has been suggested, as these markers may contribute to the development of symptoms such as central pain sensitization (9)(10)(11). One such marker is C-reactive protein (CRP), which is commonly used as an indicator of acute inflammatory processes (12).…”

Section: Introductionmentioning

confidence: 99%

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Elevated high sensitive C-reactive protein in fibromyalgia

Beiner,

Brenner Miguel,

Friederich

et al. 2023

Front. Psychiatry

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IntroductionFibromyalgia syndrome (FMS) is a complex chronic pain condition characterized by widespread pain and tenderness, fatigue, and sleep disturbances. Currently, factors contributing to FMS are considered to be multifactorial, and the involvement of inflammatory processes is a question of debate.ObjectiveThe aims of this study were (1) to assess whether serum concentrations of high-sensitivity C-reactive protein (hsCRP) differ between individuals diagnosed with FMS and pain-free controls, (2) to determine whether these differences are associated with clinical symptoms, and (3) to explore whether the observed differences can be explained by specific covariates such as age, weight, and smoking status.MethodsAn ANOVA was applied to identify differences of hsCRP levels between FMS and pain-free controls and an analysis of covariance (ANCOVA) was performed to investigate the dependencies of hsCRP with respect to covariates. To assess the reliability of our findings, we also utilized a Bayesian robust estimation model to determine the level of confidence associated with our results.ResultsThe results showed that individuals with FMS had higher hsCRP levels compared to healthy controls [F(1,106) = 8.802, p < 0.001] and that higher hsCRP levels were significant correlated with a higher symptom burden (r = 0. 287, p = 0.008) and more tender points (r = 0.307, p = 0.005). Further, hsCRP levels were significantly associated with weight (η2 = 0.154, p < 0.001), but independent of age (η2 = 0.005, p = 0.42), smoking status (η2 = 0.002, p = 0.623), or gender (η2 = 0.0045, p = 0.437), which resulted in an insignificant group effect between FMS and controls (η2 = 0.029, p = 0.052), even after controlling for covariates.ConclusionIn conclusion, this study provides evidence that sub-inflammatory processes correlate with clinical symptoms, which can be partly attributed to differences in weight, but cannot be fully explained by them. Further research is needed to elucidate the mechanisms underlying the association between hsCRP and FMS and to explore the potential therapeutic implications of targeting hsCRP in the management of FMS.

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A Link Between Inflammatory Mechanisms and Fibromyalgia

Cited by 6 publications

References 66 publications

Investigating the Effectiveness of a Carb-Free Oloproteic Diet in Fibromyalgia Treatment

Investigating the Effectiveness of a Carb-Free Oloproteic Diet in Fibromyalgia Treatment

The Role and Potential Mechanism of Complement Factor D in Fibromyalgia Development

Elevated high sensitive C-reactive protein in fibromyalgia

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