A Link between Bone Mineral Density and Serum Adiponectin and Visfatin Levels in Acromegaly

Sucunza, Nuria; Barahona, María José; Resmini, Eugenia; Fernández-Real, José Manuel; Ricart, Wifredo; Farrerons, Jordi; Espinosa, José Rodríguez; Marin, Ana-María; Puig, Teresa; Webb, Susan M.

doi:10.1210/jc.2009-0474

Cited by 53 publications

(35 citation statements)

References 42 publications

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“…These results support the view that adiponectin levels do not significantly improve during treatment of acromegaly. Contrasting to our findings, other authors did find a significant increase in adiponectin levels during acromegaly treatment, but the change was small (40,41).…”

Section: Discussioncontrasting

confidence: 99%

Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly

Verhelst

Velkeniers²,

Maiter

et al. 2013

European Journal of Endocrinology

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Objective: Patients with active acromegaly have an increased prevalence of cardiomyopathy and heart failure but a less than expected risk of coronary artery disease, considering the frequent association of diabetes mellitus and hypertension. We examined whether changes in high-sensitive C-reactive protein (hs-CRP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) might contribute to this phenomenon. Design and methods: Two hundred patients of the Belgian acromegaly registry (AcroBel) were divided in two groups: active disease (IGF1 Z-score O2; nZ95) and controlled disease (IGF1 Z-score %2; nZ105). Serum levels of hs-CRP and NT-proBNP were measured and correlated with BMI, blood pressure, fasting lipids, fasting glucose and insulin, HbA1c, IGF1, interleukin 6 (IL6), adiponectin, and sE-selectin. In a subset of acromegaly patients, hs-CRP, IL6, and NT-proBNP levels were also compared with those/the values of an age-, gender-, and BMI-matched reference group.

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Section: Discussioncontrasting

confidence: 99%

Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly

Verhelst

Velkeniers²,

Maiter

et al. 2013

European Journal of Endocrinology

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“…PBEF/NAMPT/visfatin serum levels correlated negatively with BMD in inflammatory bowel disease [38]. BMD was the predictor for visfatin in acromegaly [39]. However, no convincing data to support an association between visfatin and BMD was found in female athletes [40], Chinese men [41], and postmenopausal women [42].…”

Section: Discussionmentioning

confidence: 97%

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Tohidi

Akbarzadeh

Larijani

et al. 2012

Bone

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The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β =−0.11, p= 0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=−0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.

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“…Visfatin, prevalently secreted by visceral adipose tissue, is known to be related with the alteration in visceral adipose tissue associated with insulin resistance in non-acromegalic patients [33,34]. Although acromegaly is characterized by both adipose dysfunction and insulin resistance, data on visfatin levels in acromegaly are very scarce and in the few existing studies no difference was reported in visfatin levels between acromegalic patients and controls [35]. In the current study, the patients with uncontrolled or untreated disease showed higher visfatin, which strongly correlates with IGF-1 levels, insulin sensitivity and visceral adiposity dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Adiponectin is an insulin-sensitizing adipokine expressed in human adipose cells with anti-atherogenic and anti-inflammatory properties that plays a role in the pathophysiology of insulin resistance and metabolic syndrome [42][43][44]. Both a condition of hypoadiponectinemia and increased levels of adiponectin in acromegalic patients compared to control subjects have been demonstrated [35,45]. Silha et al [39] showed increased adiponectin levels in acromegalic patients, without direct or inverse correlation with metabolic or hormonal parameters, probably because adiponectin are negatively correlated with body fat, which is reduced in acromegaly [46].…”

Section: Discussionmentioning

confidence: 99%

Serum visfatin levels in acromegaly: Correlation with disease activity and metabolic alterations

Ciresi

Amato

Pizzolanti

2015

Growth Hormone & IGF Research

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Objective: The studies that have extensively evaluated the relation between adipokines and metabolic parameters in acromegaly treatment are quite discordant. We aimed to evaluate and correlate a set of selected adipokines, known to have a metabolic role, with the disease activity, metabolic status and treatment modalities. ND patients showed higher VAI, triglycerides, Homa-IR, and visfatin and lower ISI Matsuda, M-value, and leptin compared to other groups (all p b 0.050), while no differences were found among SA, PE and SU patients. IGF-1 (p = 0.048), M-value (p = 0.0029) and VAI (p = 0.010) were independently associated with visfatin, while only ISI Matsuda (p = 0.019) was associated with leptin. Conclusions: In acromegaly visfatin could be considered a useful index of disease activity and metabolic alterations, such as insulin resistance and adipose dysfunction, regardless of the type of treatment.

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A Link between Bone Mineral Density and Serum Adiponectin and Visfatin Levels in Acromegaly

Abstract: Acromegalic patients present hypoadiponectinemia and a favorable bone marker profile. Adiponectin and visfatin could be a link between fat mass and bone in acromegaly.

Cited by 53 publications

References 42 publications

Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly

Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Serum visfatin levels in acromegaly: Correlation with disease activity and metabolic alterations

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