This paper examines the CPD (charge priming device) ‐ type solid‐state image sensor (MN8210), which has the image size of 2/3 inch, 398 (H) × 496 (V) pixels and horizontal overflow drain structure. Discussions are made on the driving and signal processing methods, which are effective in improving the vertical transfer efficiency and the noise characteristics. By injection driving using externally injected charge, the vertical transfer efficiency can be improved up to 95 percent, independently of the signal magnitude. By using the CDS (correlated double sampling) signal treatment method, the low‐frequency noise component generated in FDA (floating diffusion amplifier) is reduced by approximately 5 dB. By the signal treatment method which picks up only the photosignal component in the two output, waveforms noise reduction of 3 dB could be achieved.