A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface

Chen, Linfeng; Wang, Wenqian; Su, Bin; Wen, Yongqiang; Li, Chuanbao; Zhou, Yabin; Li, Mingzhu; Shi, Xiaodi; Du, Hongwu; Song, Yanlin; Jiang, Lei

doi:10.1021/nn405398d

Cited by 106 publications

(78 citation statements)

References 49 publications

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“…Yildrim et al reported that mesoporous silica nanoparticles are effective ultrasound contrast agents, by releasing or nucleating microbubbles in response to focused ultrasound [225]. Finally, Chen et al synthesized mesoporous silica nanoparticles with grafted fluorocarbons and photoresponsive spiropyran [226]. The authors showed UV-triggered release of loaded fluorescein disodium and camptothecin.…”

Section: Drug Deliverymentioning

confidence: 99%

Superhydrophobic materials for biomedical applications

et al. 2016

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Superhydrophobic surfaces are actively studied across a wide range of applications and industries, and are now finding increased use in the biomedical arena as substrates to control protein adsorption, cellular interaction, and bacterial growth, as well as platforms for drug delivery devices and for diagnostic tools. The commonality in the design of these materials is to create a stable or metastable air state at the material surface, which lends itself to a number of unique properties. These activities are catalyzing the development of new materials, applications, and fabrication techniques, as well as collaborations across material science, chemistry, engineering, and medicine given the interdisciplinary nature of this work. The review begins with a discussion of superhydrophobicity, and then explores biomedical applications that are utilizing superhydrophobicity in depth including material selection characteristics, in vitro performance, and in vivo performance. General trends are offered for each application in addition to discussion of conflicting data in the literature, and the review concludes with the authors’ future perspectives on the utility of superhydrophobic surfaces for biomedical applications.

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Section: Drug Deliverymentioning

confidence: 99%

Superhydrophobic materials for biomedical applications

et al. 2016

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“…This structural conversion of spiropyran from hydrophobic to hydrophilic can induce significant solubility change for photo-triggered therapy and imaging. For instance, Chen and co-workers reported a light responsive drug release MSNs nanoplatform by adjusting the wetting behavior of hydrophobic surface 60. Briefly, the surface of spiropyran modified MSNs were protected from being wetted by water which could successfully inhibit the release of anticancer drug (CPT).…”

Section: Uv Light-mediated Theranosticsmentioning

confidence: 99%

Recent Advances of Light-Mediated Theranostics

Ai¹,

Mu²,

Xing³

2016

Theranostics

185

121

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Currently, precision theranostics have been extensively demanded for the effective treatment of various human diseases. Currently, efficient therapy at the targeted disease areas still remains challenging since most available drug molecules lack of selectivity to the pathological sites. Among different approaches, light-mediated therapeutic strategy has recently emerged as a promising and powerful tool to precisely control the activation of therapeutic reagents and imaging probes in vitro and in vivo, mostly attributed to its unique properties including minimally invasive capability and highly spatiotemporal resolution. Although it has achieved initial success, the conventional strategies for light-mediated theranostics are mostly based on the light with short wavelength (e.g., UV or visible light), which may usually suffer from several undesired drawbacks, such as limited tissue penetration depth, unavoidable light absorption/scattering and potential phototoxicity to healthy tissues, etc. Therefore, a near-infrared (NIR) light-mediated approach on the basis of long-wavelength light (700-1000 nm) irradiation, which displays deep-tissue penetration, minimized photo-damage and low autofluoresence in living systems, has been proposed as an inspiring alternative for precisely phototherapeutic applications in the last decades. Despite numerous NIR light-responsive molecules have been currently proposed for clinical applications, several inherent drawbacks, such as troublesome synthetic procedures, low water solubility and limited accumulation abilities in targeted areas, heavily restrict their applications in deep-tissue therapeutic and imaging studies. Thanks to the amazing properties of several nanomaterials with large extinction coefficient in the NIR region, the construction of NIR light responsive nanoplatforms with multifunctions have become promising approaches for deep-seated diseases diagnosis and therapy. In this review, we summarized various light-triggered theranostic strategies and introduced their great advances in biomedical applications in recent years. Moreover, some other promising light-assisted techniques, such as photoacoustic and Cerenkov radiation, were also systemically discussed. Finally, the potential challenges and future perspectives for light-mediated deep-tissue diagnosis and therapeutics were proposed.

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“…[1][2][3] One such smart material is the stimuliresponsive polymeric surface with tunable wettability under different external conditions, 4 such as pH, 5-8 electric potential, 9,10 light, [11][12][13][14] temperature, [15][16][17][18] and gas. 19 This feature enables the material to have applications in many areas, including controlled release platform, 20 ion pump, 21 and water/oil separation. [22][23][24] pH-responsive method is an attractive method to trigger the change of wettability due to its rapid response process.…”

Section: Introductionmentioning

confidence: 99%

Toward efficient water/oil separation material: Effect of copolymer composition on pH‐responsive wettability and separation performance

Zhou

Luo

2016

AIChE Journal

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Interest in functional soft matter with stimuli-responsive wettability has increasingly intensified in recent years. From the chemical product engineering viewpoint, this study aims to fabricate reversible pH-responsive polymeric surfaces with controllable wettability using [poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)-block-poly(acrylic acid) (PHFBMAb-PAA)] block copolymers. To attain this aim, three block copolymers with different PAA segment lengths were synthesized for the first time through Cu(0)-mediated reversible-deactivation radical polymerization and hydrolysis reaction. pH-induced controllable wettability was achieved by spin-coating the resulting block copolymers onto silicon wafers. Results showed that the pH-responsive wetting behavior was introduced by incorporating the PAA block, and that the responsiveness of as-fabricated surfaces was greatly influenced by PAA content. All three evolutions of water contact angle with pH shared a similar inflection point at pH 5.25. Furthermore, on the basis of the wetting properties and mechanism understanding, the application of copolymer coated meshes in layered water/oil separation was exploited. Given their superhydrophilicity and underwater superoleophobicity, PHFBMA 70 -b-PAA 148 and PHFBMA 70 -b-PAA 211 coated stainless steel meshes (SSMs) can efficiently separate water from different mixtures of organic solvent and water with high flux. However, considering long-term use, the PHFBMA 70 -b-PAA 148 coated SSM with good stability may be the best copolymer for water/oil separation. Therefore, a coordination of structure, composition, and functionality was necessary to enable practical applications of the functional materials.

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A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface

Cited by 106 publications

References 49 publications

Superhydrophobic materials for biomedical applications

Superhydrophobic materials for biomedical applications

Recent Advances of Light-Mediated Theranostics

Toward efficient water/oil separation material: Effect of copolymer composition on pH‐responsive wettability and separation performance

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