A light-operated integrated DNA walker–origami system beyond bridge burning

Liu, Xiao Rui; Loh, Iong Ying; Siti, Winna; Too, Hon Lin; Anderson, Tommy; Wang, Zhisong

doi:10.1039/d2nh00565d

Cited by 7 publications

(2 citation statements)

References 50 publications

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“…The field of rationally designed DNA molecular motors has advanced from early simplistic burning-bridge DNA molecular walkers to sophisticated DNA molecular motors capable of sustainable, scalable, and directional action under light irradiations or with supply of chemical fuels. These advanced DNA molecular motors produce nontrivial force (a few piconewtons per motor from a recent single-molecule study) and were recently integrated , with DNA origami successfully. In the long run, the marriage between the force-capable DNA molecular motors and the DNA nanotechnology of rich designability and versatile integrability with other materials (peptides, synthetic polymers, etc.)…”

Section: Research Focus 3: Bioinspired Hierarchical Materials/devicesmentioning

confidence: 99%

Mechanomaterials and Nanomechanics: Toward Proactive Design of Material Properties and Functionalities

Zou,

Sow,

Wang

et al. 2024

ACS Nano

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While conventional mechanics of materials offers a passive understanding of the mechanical properties of materials in existing forms, a paradigm shift, referred to as mechanomaterials, is emerging to enable the proactive programming of materials' properties and functionalities by leveraging force−geometry−property relationships. One of the foundations of this new paradigm is nanomechanics, which permits functional and structural materials to be designed based on principles from the nanoscale and beyond. Although the field of mechanomaterials is still in its infancy at the present time, we discuss the current progress in three specific directions closely linked to nanomechanics and provide perspectives on these research foci by considering the potential research directions, chances for success, and existing research capabilities. We believe this new research paradigm will provide future materials solutions for infrastructure, healthcare, energy, and environment.

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Section: Research Focus 3: Bioinspired Hierarchical Materials/devicesmentioning

confidence: 99%

Mechanomaterials and Nanomechanics: Toward Proactive Design of Material Properties and Functionalities

Zou,

Sow,

Wang

et al. 2024

ACS Nano

Self Cite

View full text Add to dashboard Cite

show abstract

“…DNA origami technology also provides a sub-microscale platform to guide their locomotion. Wang and co-workers have demonstrated that by driving an advanced light-powered DNA bipedal walker on a rod-shaped DNA origami platform approximately 170 nm in length [325]. Clever use of the fluorescent method allowed the researchers to analyze the self-directed, processual motion of the DNA molecular walker, which, although somewhat more complex on the surface of the DNA oligomers, essentially exhibits the motion of a translational molecular motor.…”

Section: Molecular Machine In Surface Spacementioning

confidence: 99%

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

Ariga

2024

Micromachines

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Nanotechnology has advanced the techniques for elucidating phenomena at the atomic, molecular, and nano-level. As a post nanotechnology concept, nanoarchitectonics has emerged to create functional materials from unit structures. Consider the material function when nanoarchitectonics enables the design of materials whose internal structure is controlled at the nanometer level. Material function is determined by two elements. These are the functional unit that forms the core of the function and the environment (matrix) that surrounds it. This review paper discusses the nanoarchitectonics of confined space, which is a field for controlling functional materials and molecular machines. The first few sections introduce some of the various dynamic functions in confined spaces, considering molecular space, materials space, and biospace. In the latter two sections, examples of research on the behavior of molecular machines, such as molecular motors, in confined spaces are discussed. In particular, surface space and internal nanospace are taken up as typical examples of confined space. What these examples show is that not only the central functional unit, but also the surrounding spatial configuration is necessary for higher functional expression. Nanoarchitectonics will play important roles in the architecture of such a total system.

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A Light‐Powered Single‐Stranded DNA Molecular Motor with Colour‐Selective Single‐Step Control

Anderson,

Wu,

Sirbu

et al. 2024

Angewandte Chemie

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To‐down control of small motion is possible through top‐down controlled molecular motors in replacement of larger actuators like MEMS or NEMS (micro‐ or nano‐electromechanical systems) in the current precision technology. Improving top‐down control of molecular motors to every single step is desirable for this purpose, and also for synchronization of motor actions for amplified effects. Here we report a designed single‐stranded DNA molecular motor powered by alternated ultraviolet and visible light for processive track‐walking, with the two light colours each locking the motor in a full directional step to allow saturated driving but no overstepping. This novel nano‐optomechanical driving mechanism pushes the top‐down control of molecular motors down to every single step, thus providing a key technical capability to advance the molecular motor‐based precision technology and also motor synchronization for amplified effects.

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A light-operated integrated DNA walker–origami system beyond bridge burning

Abstract: Integrating rationally designed DNA molecular walkers and DNA origami platforms is a promising route towards advanced nano-robotics of diverse functions.

Cited by 7 publications

References 50 publications

Mechanomaterials and Nanomechanics: Toward Proactive Design of Material Properties and Functionalities

Mechanomaterials and Nanomechanics: Toward Proactive Design of Material Properties and Functionalities

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

A Light‐Powered Single‐Stranded DNA Molecular Motor with Colour‐Selective Single‐Step Control

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