A light microscopic and immunohistochemical study of a multiple granular cell tumor and review of the literature

Mohs Micrographic Surgery for Granular Cell Tumor Using S-100 Immunostain

“…Abrikossoff is credited with the initial description of GCT in 1926 as a “myoblastic myoma,” although earlier reports of these lesions appeared in Muller in 1839, Weber in 1854, Heurtaux in 1881, Pendl in 1897, and Moschcowitz in 1922 2,6,7 . The tumor is now accepted as having a neural origin 6,8–10 .…”

“…Almost all GCTs are positive for S‐100 immunostaining, with the antigen being expressed on the nuclei and cytoplasm of the granular cells. In addition, GCTs have been reported to stain positively with other immunostains such as protein gene product 9.5, 75 kDa nerve growth factor receptor, NK1/C3, trk gene product, phosphotyrosine, neuron‐specific enolase, myelin basic protein, vimentin, KP1 (CD68) and Leu 7 (CD57) 1,6–10 . Other special stains reported to be positive in GCTs are periodic acid‐Schiff (PAS), Masson's trichrome, Luxal fast blue, Mallory's basic fuchsin, and Sudan black 7,14,16,18 …”

“…1,6-10 Other special stains reported to be positive in GCTs are periodic acid-Schiff (PAS), Masson's trichrome, Luxal fast blue, Mallory's basic fuchsin, and Sudan black. 7,14,16,18 Although GCTs are generally benign, there is a malignant counterpart. Malignant GCTs can have little cytologic atypia and few mitoses.…”

Oral granular cell tumour: A multicentric study of 56 cases and a systematic review

“…Most of the cases corresponded to asymptomatic slow‐growing tumours (63%). Only seven patients (2.6%) presented multiple oral GCT lesions (Apisarnthanarax, ; Baden et al, ; Bamps et al, ; Chrysomali et al, ; Collins & Jones, ; Franco et al, ; and Manara et al, ), and 5 (1.8%) presented both oral and extraoral tumours (Bomfin, Abreu, Almeida, Kowalski, & Cruz Perez, 2009; Bangle, ; Bamps et al, 2013; Sargenti‐Neto et al, ; van de Loo et al, and Vera‐Sempere, Vera‐Sirera, Zabala, Aviño‐Mira, & Vera‐Sempere, ), one of them with Noonan syndrome (Bamps et al, 2013).…”

“…The tongue and the subcutaneous tissue are the most common areas affected by this tumour, although it can appear in any part of the human organism, including viscera, and it is more common in adult patients (Lack et al, ; Machado, Cruz, Lavernia, & Llombart‐Bosch, ). Within the oral cavity, it usually develops as an asymptomatic, and slow growing, single nodule located in the submucosa (Baden, Divaris, & Quillard, ; Eguia et al, ; Van de Loo, Thunnissen, Postmus, & Waal, ; Rejas, Campos, Cortes, Pinto, & De Sousa, ) (Figure a). Cases of multiple intraoral GCT have been reported (Costa, Bertini, Carvalho, Almeida, & Cavalcante, ; Sargenti‐Neto et al, ; Tobouti, Pigatti, Martins‐Mussi, Sedassari, & Sousa, ), as well as one case associated with Noonan syndrome (Bamps, Oyen, Legius, Vandenoord, & Stas, ).…”