A Light in Multidrug Resistance: Photodynamic Treatment of Multidrug-Resistant Tumors

Capella, M&aacute;rcia Alves Marques; Capella, Luiz Sabbatini

doi:10.1159/000071155

Cited by 13 publications

(16 citation statements)

References 45 publications

(51 reference statements)

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“…So far, some studies have reported the potency of PDT in multidrug resistant cells 10. The photodynamic effect of Photofrin®(Lederle Laboratories, Oullins, France) was slightly lower in doxorubicin‐resistant Friend leukemia cell line than in the parental sensitive cell line, which might be due to increase in ABCB1‐mediated efflux of Photofrin® from the drug‐resistant cells 34.…”

Section: Discussionmentioning

confidence: 99%

Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development

Sims‐Lucas

Cusack

Baust

et al. 2010

Developmental Dynamics

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Fibroblast growth factor receptors (Fgfrs) have critical roles in kidney development. FgfrIIIb is thought to act in epithelium, while FgfrIIIc functions in mesenchyme. We aimed to determine roles of Fgfr2IIIc in kidney development. Mice with deletion of Fgfr2IIIc (Fgfr2IIIc−/−) had normal kidneys. Combination of Fgfr2IIIc−/− with conditional deletion of Fgfr1 in metanephric mesenchyme (MM) (Fgfr1Mes−/−Fgfr2IIIc−/−) had small but identifiable MM at E10.5, expressing mesenchymal markers including Eya1, Six2, Pax2 and Gdnf (unlike Fgfr1/2Mes−/− mice that have no obvious MM). E11.5 Fgfr1Mes−/−Fgfr2IIIc−/− mice had rudimentary MM expressing only Eya1. Control, Fgfr2IIIc−/−, and Fgfr1Mes−/−Fgfr2IIIc−/− kidney mesenchymal tissues also express Fgfr2IIIb. In ureteric lineages, E10.5 Fgfr1Mes−/−Fgfr2IIIc−/− embryos had ureteric outgrowth (sometimes multiple buds); however, by E11.5 Gdnf absence lead to no ureteric elongation or branching (similar to Fgfr1/2Mes−/− mice). Beyond E12.5, Fgfr1Mes−/−Fgfr2IIIc−/− mice had no renal tissue. In conclusion, Fgfr2IIIc and Fgfr1 in kidney mesenchyme (together) are critical for normal early renal development.

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Section: Discussionmentioning

confidence: 99%

Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development

Sims‐Lucas

Cusack

Baust

et al. 2010

Developmental Dynamics

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“…260-263 Their results, although still inconclusive, have opened the possibility of treating multidrug-resistant tumours with PDT. 264 …”

Section: Future Trendsmentioning

confidence: 99%

Milestones in the development of photodynamic therapy and fluorescence diagnosis

Juzeniene

Peng

Moan

2007

Photochem Photobiol Sci

250

196

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Many reviews on PDT have been published. This field is now so large, and embraces so many sub-specialties, from laser technology and optical penetration through diffusing media to a number of medical fields including dermatology, gastroenterology, ophthalmology, blood sterilization and treatment of microbial-viral diseases, that it is impossible to cover all aspects in a single review. Here, we will concentrate on a few basic aspects, all important for the route of development leading PDT to its present state: early work on hematoporphyrin and hematoporphyrin derivative, second and third generation photosensitizers, 5-aminolevulinic acid and its derivatives, oxygen and singlet oxygen, PDT effects on cell organelles, mutagenic potential, the basis for tumour selectivity, cell cooperativity, photochemical internalization, light penetration into tissue and the significance of oxygen depletion, photobleaching of photosensitizers, optimal light sources, effects on the immune system, and, finally, future trends.

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“…In addition, due to its low risk, can be used in people who are elderly or frail to undergo other surgery. The main side effect is sensitization to light, which is circumvented by avoiding exposure to sunlight and interior light too intense for a period of up to 6 weeks depending on the photosensitizer 45.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic antimicrobial chemotherapy (PACT) using phenothiazine derivatives as photosensitizers against Leishmania braziliensis

et al. 2012

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A Light in Multidrug Resistance: Photodynamic Treatment of Multidrug-Resistant Tumors

Cited by 13 publications

References 45 publications

Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development

Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development

Milestones in the development of photodynamic therapy and fluorescence diagnosis

Photodynamic antimicrobial chemotherapy (PACT) using phenothiazine derivatives as photosensitizers against Leishmania braziliensis

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