A light and electron microscopic study of lamellated nerve endings found in the rat cheek mucosa.

Watanabe, Ii-sei; Yamada, Eichi

doi:10.1679/aohc.48.497

Cited by 15 publications

(10 citation statements)

References 20 publications

(16 reference statements)

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“…The fine structures of the sensory nerve endings were reported in the rat gingiva by Martinez and Pekarthy (1974) and Watanabe and Yamada (1979, 1983), in the rat lip by Tachibana et al . (1987) and Watanabe and Ide (1987), in the cat cheek by Watanabe and Yamada (1985), and in the tongue fungiform papillae by Toyoshima et al . (1987) and Watanabe and Ide (1991).…”

Section: Lamellated Mechanoreceptive Corpusclesmentioning

confidence: 97%

“…Sensory nerve endings found in the lamina propria of cheek mucosa of mouse and rat are encapsulated and composed of the axon terminals and associated lamellae of cytoplasmic processes of lamellar cells (Watanabe & Semprini, 1985; Watanabe & Yamada, 1985). The fine structures of the sensory nerve endings were reported in the rat gingiva by Martinez and Pekarthy (1974) and Watanabe and Yamada (1979, 1983), in the rat lip by Tachibana et al .…”

Section: Lamellated Mechanoreceptive Corpusclesmentioning

confidence: 99%

“…Usually, the corpuscular endings within the connective tissue papillae are formed by a grouping of two to several small corpuscles, depending on the size of the papillae. Intraepithelial axon terminals are described in the mucosae of soft palate, tongue, cheek and gingiva (Munger, 1965; Watanabe & Yamada, 1979, 1985; Muller, 1996) (Fig. 1).…”

Section: Lamellated Mechanoreceptive Corpusclesmentioning

confidence: 99%

“…2). The fine structure of free nerve endings have been studied in the soft and hard palate mucosa of mouse and rats by Watanabe and Yamada (1984, 1985, 1989).…”

Section: Free Nerve Endingsmentioning

confidence: 99%

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Ultrastructures of mechanoreceptors in the oral mucosa

Watanabe

2004

Anat Sci Int

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The present review describes the fine structures of lamellated mechanoreceptive corpuscles, Merkel cell-neurite complexes and free nerve endings in the oral mucosae of mammals, with special attention to axon terminals and lamellar cells. The mechanoreceptive nerve endings of the oral mucosa were studied using histochemistry, immunohistochemistry and transmission electron microscopy techniques. The organized mechanoreceptive corpuscles are present in the mucosae of gingiva, cheek, tongue and soft and hard palate. They are elongated or globular in shape, being located in the connective tissue papillae. The capsule is composed of several layers of cytoplasmic extensions of perineural cells. Numerous bundles of collagen fibers are noted at the periphery of the corpuscle. The lamellated corpuscles are surrounded by several layers of superimposed flattened capsular cell processes. The interlamellar spaces are 0.2-0.4 micron in width and filled with thin fibrillar collagen fibers embedded in the amorphous substance. The lamellar cells contain rich microtubules and are characterized by the presence of caveolae on the surface plasma membrane. The terminal axon contains an abundance of mitochondria and small clear vesicles (20-50 nm in diameter). There are neurofilaments in the center of the axon terminal. Intermediate-type junctions are seen between the adjacent lamellar cells and between the axon and adjacent lamellae. The free nerve endings are found in the subepithelial regions, very close to the basal laminae of mucosal epithelium. They are surrounded by a thin cytoplasm of Schwann cells. Sometimes Schwann cell basal larinae become multilayered. Merkel cells are present within the basal layer of mucosal epithelium and contain characteristic electron-dense granules that are located almost exclusively at the side of cytoplasm in contact with axon terminals. Intermediate-type junctions are noted between axon terminals and Merkel cells.

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Section: Lamellated Mechanoreceptive Corpusclesmentioning

confidence: 97%

Section: Lamellated Mechanoreceptive Corpusclesmentioning

confidence: 99%

Section: Lamellated Mechanoreceptive Corpusclesmentioning

confidence: 99%

“…2). The fine structure of free nerve endings have been studied in the soft and hard palate mucosa of mouse and rats by Watanabe and Yamada (1984, 1985, 1989).…”

Section: Free Nerve Endingsmentioning

confidence: 99%

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Ultrastructures of mechanoreceptors in the oral mucosa

Watanabe

2004

Anat Sci Int

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“…Desmosome‐like junctions are present between lamellae and between the inner lamellae and the axon terminal. The axon is filled with mitochondria, microtubules, and vesicles . The interspaces between the axon terminal and the inner cytoplasmic lamellae are not filled with collagen fibers, but the axon terminal presents projections that trespass the first line of lamellae and reach the collagen fibers in the interlamellae space; these projections are characterized by containing many vesicles (Fig.…”

Section: Ultrastructure Of the Specialized Sensory Structuresmentioning

confidence: 99%

Oropharyngeal and laryngeal sensory innervation in the pathophysiology of swallowing disorders and sensory stimulation treatments

Álvarez-Berdugo

Rofes

Casamitjana

et al. 2016

Annals of the New York Academy of Sciences

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Oropharyngeal dysphagia (OD) affects older and neurological patients, causing malnutrition and dehydration and increasing the risk for aspiration pneumonia. There is evidence that sensory deficits in those populations are closely related to swallowing disorders, and several research groups are developing new therapies based on sensory stimulation of this area. More information on the sensory innervation participating in the swallow response is needed to better understand the pathophysiology of OD and to develop new treatments. This review focuses on the sensory innervation of the human oropharynx and larynx in healthy people compared with patients with swallowing disorders in order to unravel the abnormalities that may lead to the loss of sensitivity in patients with OD. We also hypothesize the pathway through which active sensory-enhancement treatments may elicit their therapeutic effect on patients with swallowing dysfunctions. As far as we know, this is the first time a review covers the anatomy, histology, ultrastructure, and molecular biology of the sensory innervation of the swallowing function.

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