A lifetime in photochemistry; some ultrafast measurements on singlet states

Phillips, David

doi:10.1098/rspa.2016.0102

Cited by 14 publications

(8 citation statements)

References 89 publications

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“…For the type II mechanism, the triplet excited PS directly transfers energy to oxygen to form singlet oxygen ( 1 O 2 ), which is considered to be the more common ROS in most cases. 452 …”

Section: Nanotherapeutics Applicationsmentioning

confidence: 99%

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

et al. 2020

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“…For the type II mechanism, the triplet excited PS directly transfers energy to oxygen to form singlet oxygen ( 1 O 2 ), which is considered to be the more common ROS in most cases. 452 …”

Section: Nanotherapeutics Applicationsmentioning

confidence: 99%

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

et al. 2020

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“…The first reports that use TCSPC in the measurement of fluorescence decays appear in the early 1970s [21][22][23][24], and TCSPC was soon widely used for time-resolved spectroscopy, and in particular the measurement of fluorescence lifetimes in solution [25].…”

Section: Fast Timing In Fluorescencementioning

confidence: 99%

Fast Timing Techniques in FLIM Applications

Hirvonen

Suhling

2020

Front. Phys.

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Fluorescence lifetime imaging (FLIM) is increasingly used in many scientific disciplines, including biological and medical research, materials science and chemistry. The fluorescence label is not only used to indicate its location, but also to probe its immediate environment, via its fluorescence lifetime. This allows FLIM to monitor and image the cellular microenvironment including the interaction between proteins in their natural environment. It does so with high specificity and sensitivity in a non-destructive and minimally invasive manner, providing both structural and functional information. Time-Correlated Single Photon Counting (TCSPC) is a popular, widely used, robust and mature method to perform FLIM measurements. It is a sensitive, accurate and precise method of measuring photon arrival times after an excitation pulse, with the arrival times not affected by photobleaching, excitation or fluorescence intensity fluctuations. It has a very large dynamic range, and only needs a low illumination intensity. Different methods have been developed to advance fast and accurate timing of photon arrival. In this review a brief history of the development of these methods is given, and their merits are discussed in the context of their applications in FLIM.

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“…Some quenchers seem to donate electrons to the excited state by inducing intersystem crossing by others, such as aromatic amines, or phtahlocyanines . Phillips discusses several molecular mechanisms to account for this phenomenon. Potassium iodide is an example of a quencher for methanolic cresyl violet.…”

Section: Uncertaintymentioning

confidence: 99%

Experimental methods in chemical engineering: Fluorescence emission spectroscopy

et al. 2019

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Fluorescence is a luminescence phenomenon in which a compound emits light after absorption of electromagnetic irradiation. Specialized terms such as photoluminescence, cathodoluminescence, anodoluminescence, radioluminescence, and x-ray fluorescence sometimes are used to indicate the type of exciting radiation. Fluorescence spectroscopy provides reliable quantitative and qualitative data. It precisely tracks chemical reactions from fluorescent materials compounds with aromatic groups, or conjugated planar, or cyclic molecules. It is up to 1000 times more sensitive than UV-vis or infrared spectroscopy. Fluorescence intensity depends on the fluorophore (compound that fluoresces), its concentration, excitation and emission wavelengths, temperature and contamination. We adjust the slit dimensions, photomultiplier tube voltage and bandpass filter cutoff to maximize the signal while avoiding saturating the detector. Together with x-ray diffraction, it is the most common spectroscopic technique with applications in geology, chemistry, medicine, and astronomy. A bibliometric analysis of the top 10 000 cited papers identified 5 clusters based on keywords centered around: (1) cancer, cells, and proteins;(2) aggregation induced emission, LED, and complexes; (3) live cells, sensors, and probes; (4) quantum dots, DNA, and biosensors; and (5) nanoparticles, in vivo, and drug delivery. Chemical engineers have yet to fully embrace fluorescence spectroscopy as the category is ranked 16th among all scientific categories that exploit it.

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A lifetime in photochemistry; some ultrafast measurements on singlet states

Cited by 14 publications

References 89 publications

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

Fast Timing Techniques in FLIM Applications

Experimental methods in chemical engineering: Fluorescence emission spectroscopy

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