A life-threatening case of disseminated nocardiosis due to <i>Nocardia brasiliensis</i>

Paramythiotou, Elisabeth; Papadomichelakis, Evangelos; Vrioni, Georgia; Pappas, Georgios; Pantelaki, M.; Kontos, Fanourios; Zerva, Loukia; Armaganidis, A

doi:10.4103/0972-5229.106512

Cited by 8 publications

(9 citation statements)

References 10 publications

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“…Although nocardiosis usually occurs in patients with cellmediated immunosuppressive diseases, infections sometimes occur in patients with normal immune functions. [1] Nocardia is a ubiquitous environmental organism that can cause local or disseminated infections in humans. Causes a variety of diseases, infects the lungs, skin, soft tissues, and in some cases also infects the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

“…On Columbia blood agar, Nocardia brasiliensis (N. brasiliensis) forms white, chalky colonies that are Gram-positive branching, aerobic bacteria. [ 1 ] Living in soil (an excellent source of oxygen since plants produce oxygen) and eating dead or decaying plants, this organism thrives.This infection is usually acquired through ingestion, inoculation, or punctures by something contaminated with N. brasiliensis. [ 2 ] Nocardiosis, a rare but potentially fatal infection, is caused by this microbe.…”

Section: Introductionmentioning

confidence: 99%

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Severe disseminated Nocardia brasiliensis pneumonia with normal immune function: A case report

Wang,

Yang,

Xie

et al. 2024

Medicine

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Rationale: Members of the genus Nocardia brasiliensis are Gram-positive, aerobic bacteria and exist ubiquitously in most environments. In recent years, the incidence of Nocardia brasiliensis has increased significantly and become a global concern. It may be predominantly caused pulmonary infections in immunocompromised hosts. Interestingly, however, we found that it can be present not only on immunocompromised hosts, but also to infect patients with a normal immune system. Patient concerns: We report a very rare case of a 49-year-old immunocompetent man with disseminated Nocardia brasensis pneumonia. He had a fever for 14 days (maximum temperature about 38°C) and a history of mass rupture. Diagnoses: Severe Disseminated Nocardia brasiliensis pneumonia with normal immune function. Interventions: No. Outcomes: The patient was finally diagnosed with Severe Disseminated Nocardia brasiliensis pneumonia and received compound sulfamethoxazole treatment for 4 months. Lessons subsections: Our report highlights when cold pus appears in soft tissues such as the lower limbs, neck, nose, scalp, etc, should prompt timely evaluation and biopsy for definitive diagnosis. Be alert to a normally immunocompetent, disseminated Nocardia brasiliensis infection. Early recognition and effective treatment are necessary conditions for successful results. This would allow for better disease prognostication while enabling physicians to develop more effective treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Severe disseminated Nocardia brasiliensis pneumonia with normal immune function: A case report

Wang,

Yang,

Xie

et al. 2024

Medicine

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“…According to two reviews on pulmonary nocardiosis, empirical combination therapy with amikacin and imipenem (or meropenem) or a three-drug regimen comprising of sulfonamides, amikacin, and either a carbapenem or third-generation cephalosporin can be used in such high-risk patients. [ 2 13 ]…”

Section: Discussionmentioning

confidence: 99%

Pulmonary nocardiosis and scrub typhus in an immunocompromised host

Princess¹,

Ebenezer

Ramakrishnan

et al. 2018

J Global Infect Dis

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Pulmonary infections are not uncommon in patients with an underlying immunocompromised condition. Unusual combination of microorganisms causing concomitant infections among these patients has also been reported. However, certain rare dual occurrences are usually unanticipated as in the case we present here. This case highlights the importance of being aware of the possible coexistence of infections in immunocompromised patients. To the best of our knowledge, this is the first report of coinfection with Nocardia otitidiscaviarum and Orientia tsutsugamushi in a critically ill immunocompromised patient from South India.

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“…Nocardia asteroides is the predominant human pathogen followed by Nocardia brasiliensis, Nocardia farcinica, and Nocardia nova. 40…”

Section: Descriptionmentioning

confidence: 99%

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

et al. 2019

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Bacterial infections are common causes of sepsis in the intensive care units. However, usually a finite number of Gram-negative bacteria cause sepsis (mostly according to the hospital flora). Some organisms such as Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus are relatively common. Others such as Stenotrophomonas maltophilia, Chryseobacterium indologenes, Shewanella putrefaciens, Ralstonia pickettii, Providencia, Morganella species, Nocardia, Elizabethkingia, Proteus, and Burkholderia are rare but of immense importance to public health, in view of the high mortality rates these are associated with. Being aware of these organisms, as the cause of hospital-acquired infections, helps in the prevention, treatment, and control of sepsis in the high-risk cardiac surgical patients including in heart transplants. Therefore, a basic understanding of when to suspect these organisms is important for clinical diagnosis and initiating therapeutic options. This review discusses some rarely appearing pathogens in our intensive care unit with respect to the spectrum of infections, and various antibiotics that were effective in managing these bacteria.

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A life-threatening case of disseminated nocardiosis due to Nocardia brasiliensis

Cited by 8 publications

References 10 publications

Severe disseminated Nocardia brasiliensis pneumonia with normal immune function: A case report

Severe disseminated Nocardia brasiliensis pneumonia with normal immune function: A case report

Pulmonary nocardiosis and scrub typhus in an immunocompromised host

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

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