A library of thiol‐terminated methacrylate telomers prepared by photoinitiated iniferter mediated polymerization for use in modifications of chromatographic surfaces by the “grafting to” approach

Abstract

A library of thiol-terminated methacrylate telomers aimed for use in surface modifications of chromatographic support materials has been prepared by iniferter mediated polymerization, using isopropylxanthic disulfide as a photoiniferter. The telomers range from hydrophobic to hydrophilic and were prepared in different lengths, with the length being adjusted by the ratio of monomer to iniferter used in the polymerization mixture. The telomers were characterized by size-exclusion chromatography and MALDI-TOF-MS. In initial surface characterization experiments, the prepared telomers were attached to the inner surface of fused silica capillaries by radical initiated addition to vinyl groups, and the electro-osmotic flow (EOF) in the prepared capillaries was determined in a capillary electrophoresis set-up. The EOF measurements verified surface grafting.

Plasma brominated polymer particles as grafting substrate for thiol‐terminated telomers

“…In this paper we present a new activation route for particulate separation material surfaces and their subsequent functionalization via “grafting to”. Highly cross‐linked divinylbenzene (DVB) particles served as substrate, since they are easily prepared by photoinitiated precipitation polymerization and have proven to be suitable as support material in LC separation columns, both in terms of withstanding high back‐pressures, and by their abundance of vinyl groups covering the particles facilitating surface functionalization 24–26.…”